Cited by 202Neuroscience and Neuropharmacology ResearchRegulation of Appetite and ObesityMemory and Neural Mechanisms

Leptin and its role in hippocampal synaptic plasticity

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HARVEY, J, SOLOVYOVA, N, IRVING, A·2006·Progress in Lipid Research

Abstract

It is well documented that the hormone leptin plays a pivotal role in regulating food intake and body weight via its hypothalamic actions. However, leptin receptors are expressed throughout the brain with high levels found in the hippocampus. Evidence is accumulating that leptin has widespread actions on CNS function and in particular learning and memory. Recent studies have demonstrated that leptin-deficient or-insensitive rodents have impairments in hippocampal synaptic plasticity and in spatial memory tasks performed in the Morris water maze. Moreover, direct administration of leptin into the brain facilitates hippocampal long-term potentiation (LTP), and improves memory performance in mice. There is also evidence that, at the cellular level, leptin has the capacity to convert hippocampal short-term potentiation (STP) into LTP, via enhancing NMDA receptor function. Recent data indicates that leptin can also induce a novel form of NMDA receptor-dependent hippocampal long-term depression. Here, we review the evidence implicating a key role for the hormone leptin in modulating hippocampal synaptic plasticity and discuss the role of lipid signaling cascades in this process.

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  • Neural activity in brain areas involved in cognitive processing of food representations, such as the amygdala and hippocampal complex, is modulated by leptin and ghrelin.

    “Furthermore, neural activity in brain areas thought to be involved in cognitive processing of representations of food such as the amygdala and hippocampal complex is modulated by leptin ([78](#B78), [79](#B79), [105](#B105)) and ghrelin ([27](#B27), [50](#B50), [92](#B92), [109](#B109), [147](#B147), [189](#B189)).”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [79]

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Authors
HARVEY, J., SOLOVYOVA, N., & IRVING, A.
Affiliations
University of Dundee (GB)
Corresponding author
HARVEY, J
Venue
Progress in Lipid Research
Publisher
Elsevier BV
Published
2006-09
Volume
45
Issue
5
Pages
369-378
ISSN
0163-7827 (ISSN-L)
OpenAlex
W2070216489
Cited by
202
References
95
Citations by year
2026: 5 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 19 · 2013: 12 · 2012: 14
FWCI
3.54
Type
journal article
Language
en
Open access
Locations
  • Progress in Lipid Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion)
Funders
  • Wellcome Trust (075821)
  • Biotechnology and Biological Sciences Research Council (C18771)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
leptin, hippocampus, synaptic plasticity, long-term potentiation, short-term potentiation, long-term depression, NMDA receptor, learning and memory, spatial memory, lipid signaling, leptin receptor, leptin deficiency
MeSH terms
Animals, Hippocampus, Humans, Neuronal Plasticity, Receptors, Cell Surface, Synapses, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Leptin, Rats, Receptors, Leptin

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