Leptin and its role in hippocampal synaptic plasticity
Open accessAbstract
It is well documented that the hormone leptin plays a pivotal role in regulating food intake and body weight via its hypothalamic actions. However, leptin receptors are expressed throughout the brain with high levels found in the hippocampus. Evidence is accumulating that leptin has widespread actions on CNS function and in particular learning and memory. Recent studies have demonstrated that leptin-deficient or-insensitive rodents have impairments in hippocampal synaptic plasticity and in spatial memory tasks performed in the Morris water maze. Moreover, direct administration of leptin into the brain facilitates hippocampal long-term potentiation (LTP), and improves memory performance in mice. There is also evidence that, at the cellular level, leptin has the capacity to convert hippocampal short-term potentiation (STP) into LTP, via enhancing NMDA receptor function. Recent data indicates that leptin can also induce a novel form of NMDA receptor-dependent hippocampal long-term depression. Here, we review the evidence implicating a key role for the hormone leptin in modulating hippocampal synaptic plasticity and discuss the role of lipid signaling cascades in this process.
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Neural activity in brain areas involved in cognitive processing of food representations, such as the amygdala and hippocampal complex, is modulated by leptin and ghrelin.
“Furthermore, neural activity in brain areas thought to be involved in cognitive processing of representations of food such as the amygdala and hippocampal complex is modulated by leptin ([78](#B78), [79](#B79), [105](#B105)) and ghrelin ([27](#B27), [50](#B50), [92](#B92), [109](#B109), [147](#B147), [189](#B189)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [79]
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- Authors
- HARVEY, J., SOLOVYOVA, N., & IRVING, A.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- HARVEY, J
- ORCID
- HARVEY, J
- Venue
- Progress in Lipid Research
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 45
- Issue
- 5
- Pages
- 369-378
- ISSN
- 0163-7827 (ISSN-L)
- PMC
- PMC1762032
- OpenAlex
- W2070216489
- Cited by
- 202
- References
- 95
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 19 · 2013: 12 · 2012: 14
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Lipid Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Funders
- Wellcome Trust (075821)
- Biotechnology and Biological Sciences Research Council (C18771)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- leptin, hippocampus, synaptic plasticity, long-term potentiation, short-term potentiation, long-term depression, NMDA receptor, learning and memory, spatial memory, lipid signaling, leptin receptor, leptin deficiency
- MeSH terms
- Animals, Hippocampus, Humans, Neuronal Plasticity, Receptors, Cell Surface, Synapses, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Leptin, Rats, Receptors, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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