Dietary status and impact of risperidone on nutritional balance in children with autism: A pilot study
Abstract
BACKGROUND: Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain. METHOD: Using a quantitative Food Frequency Questionnaire (FFQ), we prospectively examined the nutritional intake of 20 children with autism participating in a randomised placebo-controlled trial of risperidone for disruptive behaviours. RESULTS: At baseline, the mean intakes for macronutrients, vitamins and minerals exceeded Dietary Reference Intakes (DRIs). However there was substantial inter-participant variability, with individual deficiencies (<80% of DRI) in the intake of calcium (9 of 20 participants), pantothenic acid (6 of 20), vitamin D (5 of 20) and vitamin K (8 of 20). For the participants for whom FFQs were available, there was an increase in weight and an increase in vitamin K intake after 2 months of risperidone treatment (n = 9) compared to placebo (n = 8). An additional 4 months of risperidone treatment (n = 8) did not result in significant changes in reported nutritional balance. CONCLUSION: These pilot data suggest that treatment with risperidone did not significantly affect the nutritional balance of this small group of children.
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Evidence suggests that a large proportion of children with ASD do not meet vitamin D requirements.
“Evidence suggests that a large proportion of children with ASD do not meet vitamin D requirements [126,132,133,134,135,136].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [135]
Although these studies illustrated a large proportion of children with ASD not meeting the recommendations for vitamin D intake, they did not find any evidence that dietary intake of vitamin D in children with ASD differed from that of typically developing controls.
“Although these studies illustrated a large proportion of children with ASD not meeting the recommendations for vitamin D intake, they did not find any evidence that dietary intake of vitamin D in children with ASD differed from that of typically developing controls.”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [135]
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- Authors
- Lindsay, R. L., Eugene Arnold, L., Aman, M. G., Vitiello, B., Posey, D. J., McDougle, C. J., Scahill, L., Pachler, M., McCracken, J. T., Tierney, E., & Bozzolo, D.
- Affiliations
- St. Joseph's Hospital and Medical Center (US)
- Ohio State University, Columbus, Ohio
- The Ohio State University (US)
- National Institute of Mental Health (US)
- Indiana University School of Medicine (US)
- Yale University (US)
- University of California, Los Angeles (US)
- Kennedy Krieger Institute (US)
- Corresponding author
- Lindsay, Ronald L.
- Venue
- Journal of Intellectual & Developmental Disability
- Publisher
- Informa UK Limited
- Published
- 2006-12
- Volume
- 31
- Issue
- 4
- Pages
- 204-209
- ISSN
- 0045-0634 (ISSN-L)
- 1366-8250
- 1469-9532
- OpenAlex
- W2021300378
- Cited by
- 52
- References
- 8
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 4 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Intellectual & Developmental Disability (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- National Institutes of Health (n01mh070009-000, n01mh070001-008, n01mh070010-001, n01mh080011-005)
- National Institute of Mental Health (N01-MH-80011, N01 MH 70010, N01 MH-70001, N01 MH 70009, MH 01805, K24MH001805)
- National Center for Research Resources (M01-RR 00750, M01 RR-00052, M01-RR-00034, M01RR006022, M01RR000750, M01RR000052, M01 RR-06022, M01RR000034)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- risperidone, autism spectrum disorder, children, nutritional status, dietary intake, macronutrients, micronutrient deficiency, calcium, vitamin D, vitamin K, pantothenic acid, weight gain, antipsychotic adverse effects, disruptive behavior
- MeSH terms
- Adolescent, Autistic Disorder, Body Weight, Child, Child Nutritional Physiological Phenomena, Child, Preschool, Diet, Double-Blind Method, Female, Humans, Male, Nutrition Surveys, Nutritional Status, Pilot Projects, Prospective Studies, Surveys and Questionnaires, Antipsychotic Agents, Diet Records, Risperidone
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