The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
The relationship between circulating testosterone and inflammatory cytokines in men
Open accessAbstract
Testosterone is the predominant gonadal androgen in men. Low testosterone levels are found to be associated with an increased in metabolic risk and systematic inflammation. Since adipose tissue is a source of inflammatory cytokines, testosterone may regulate inflammation by acting on adipose tissue. This review aimed to explore the role of testosterone in inflammation and its mechanism of action. Both animal studies and human studies showed that (1) testosterone deficiency was associated with an increase in pro-inflammatory cytokines; (2) testosterone substitution reduced pro-inflammatory cytokines. The suppression of inflammation by testosterone were observed in patients with coronary artery disease, prostate cancer and diabetes mellitus through the increase in anti-inflammatory cytokines (IL-10) and the decrease in pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Despite these, some studies also reported a non-significant relationship. In conclusion, testosterone may possess anti-inflammatory properties but its magnitude is debatable. More evidence is needed to validate the use of testosterone as a marker and in the management of chronic inflammatory diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,110
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · cited 1×
“Excessive visceral fat is a cause of chronic inflammation because adipose tissue is a major source of pro-inflammatory mediators [9].”
BackgroundMalkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731
Inflammatory Mechanisms: The Molecular Basis of Inflammation and Disease
Libby, P. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00352.x · Cited by 596
Testosterone treatment and mortality in men with low testosterone levels
Shores, M. M., Smith, N. L., Forsberg, C. W., Anawalt, B. D., & Matsumoto, A. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2591 · Cited by 460
Bellido, T., Jilka, R. L., Boyce, B. F., Girasole, G., Broxmeyer, H., Dalrymple, S. A., Murray, R., & Manolagas, S. C. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117995 · Cited by 430
Testosterone Acts Directly on CD4+ T Lymphocytes to Increase IL-10 Production
Liva, S. M., & Voskuhl, R. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2060 · Cited by 394
Muraleedharan, V., Marsh, H., Kapoor, D., Channer, K. S., & Jones, T. H. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0321 · Cited by 389
Rettew, J. A., Huet-Hudson, Y. M., & Marriott, I. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.063545 · Cited by 376
Cited by
Androgens, Endometriosis and Pain
Evans, S. F., Hull, M. L., Hutchinson, M. R., & Rolan, P. E. (2021) · Frontiers in Reproductive Health · doi:10.3389/frph.2021.792920 · Cited by 14
Zhang, L., Altemus, J., Ding, L., Cherepanova, O., Byzova, T. V., & Podrez, E. A. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105425 · Cited by 1
Metadata
- Authors
- Mohamad, N.-V., Wong, S. K., Wan Hasan, W. N., Jolly, J. J., Nur-Farhana, M. F., Ima-Nirwana, S., & Chin, K.-Y.
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2018-06-21
- Volume
- 22
- Issue
- 2
- Pages
- 129-140
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- OpenAlex
- W2808755202
- Cited by
- 312
- References
- 54
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The relationship between circulating testosterone and inflammatory cytokines in men. https://app.cochat.ai/papers/10.1080/13685538.2018.1482487
- The paper
- Mohamad, N.-V., Wong, S. K., Wan Hasan, W. N., Jolly, J. J., Nur-Farhana, M. F., Ima-Nirwana, S., & Chin, K.-Y. (2019). The relationship between circulating testosterone and inflammatory cytokines in men. The Aging Male. https://doi.org/10.1080/13685538.2018.1482487
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
