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Cited by 596

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Inflammatory Mechanisms: The Molecular Basis of Inflammation and Disease

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Libby, Peter·2008·Nutrition Reviews
DOI 10.1111/j.1753-4887.2007.tb00352.x
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Abstract

Inflammation participates importantly in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of many chronic diseases. Interactions of cells in the innate immune system, adaptive immune system, and inflammatory mediators orchestrate aspects of the acute and chronic inflammation that underlie diseases of many organs. A coordinated series of common effector mechanisms of inflammation contribute to tissue injury, oxidative stress, remodeling of the extracellular matrix, angiogenesis, and fibrosis in diverse target tissues. Atherosclerosis provides an example of a chronic disease that involves inflammatory mechanisms. Recruitment of blood leukocytes characterizes the initiation of this disease. Its progression involves many inflammatory mediators, modulated by cells of both innate and adaptive immunity. The complications of established atheroma, including plaque disruption and thrombosis, also intimately involve inflammation. Mastery of the inflammatory response should aid the development of novel strategies to predict disease susceptibility, target and monitor therapies, and ultimately develop new approaches to the prevention and treatment of chronic diseases associated with aging, such as atherosclerosis.

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Metadata

Authors
Libby, P.
Venue
Nutrition Reviews
Publisher
Oxford University Press (OUP)
Published
2008-06-28
Volume
65
Issue
12 Pt 2
Pages
S140-S146
ISSN
0029-6643 (ISSN-L)
DOI
10.1111/j.1753-4887.2007.tb00352.x
OpenAlex
W2002926183
Cited by
596
References
7
FWCI
11.02
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Inflammatory Mechanisms: The Molecular Basis of Inflammation and Disease. https://app.cochat.ai/papers/10.1111/j.1753-4887.2007.tb00352.x
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Libby, P. (2008). Inflammatory Mechanisms: The Molecular Basis of Inflammation and Disease. Nutrition Reviews. https://doi.org/10.1111/j.1753-4887.2007.tb00352.x

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