The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
The anti-inflammatory activity of licorice, a widely used Chinese herb
Open accessAbstract
CONTEXT: Increasing incidence and impact of inflammatory diseases have encouraged the search of new pharmacological strategies to face them. Licorice has been used to treat inflammatory diseases since ancient times in China. OBJECTIVE: To summarize the current knowledge on anti-inflammatory properties and mechanisms of compounds isolated from licorice, to introduce the traditional use, modern clinical trials and officially approved drugs, to evaluate the safety and to obtain new insights for further research of licorice. METHODS: PubMed, Web of Science, Science Direct and ResearchGate were information sources for the search terms 'licorice', 'licorice metabolites', 'anti-inflammatory', 'triterpenoids', 'flavonoids' and their combinations, mainly from year 2010 to 2016 without language restriction. Studies were selected from Science Citation Index journals, in vitro studies with Jadad score less than 2 points and in vivo and clinical studies with experimental flaws were excluded. RESULTS: Two hundred and ninety-five papers were searched and 93 papers were reviewed. Licorice extract, 3 triterpenes and 13 flavonoids exhibit evident anti-inflammatory properties mainly by decreasing TNF, MMPs, PGE2 and free radicals, which also explained its traditional applications in stimulating digestive system functions, eliminating phlegm, relieving coughing, nourishing qi and alleviating pain in TCM. Five hundred and fifty-four drugs containing licorice have been approved by CFDA. The side effect may due to the cortical hormone like action. CONCLUSION: Licorice and its natural compounds have demonstrated anti-inflammatory activities. More pharmacokinetic studies using different models with different dosages should be carried out, and the maximum tolerated dose is also critical for clinical use of licorice extract and purified compounds.
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Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review
Pastorino, G., Cornara, L., Soares, S., Rodrigues, F., & Oliveira, M. B. P. P. (2018) · Phytotherapy Research · doi:10.1002/ptr.6178 · Cited by 804
Narwal, N., Katyal, D., Kataria, N., Rose, P. K., Warkar, S. G., Pugazhendhi, A., Ghotekar, S., & Khoo, K. S. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139945 · Cited by 105
Recent advances in chemical analysis of licorice (Gan-Cao)
Cheng, M., Zhang, J., Yang, L., Shen, S., Li, P., Yao, S., Qu, H., Li, J., Yao, C., Wei, W., et al. (2021) · Fitoterapia · doi:10.1016/j.fitote.2020.104803 · Cited by 84
Niu, H., Sanabria-Cabrera, J., Alvarez-Alvarez, I., Robles-Diaz, M., Stankevičiūtė, S., Aithal, G. P., Björnsson, E. S., Andrade, R. J., & Lucena, M. I. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105404 · Cited by 58
Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways
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Metadata
- Authors
- Yang, R., Yuan, B.-C., Ma, Y.-S., Zhou, S., & Liu, Y.
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2016-09-21
- Volume
- 55
- Issue
- 1
- Pages
- 5-18
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2521532521
- Cited by
- 396
- References
- 77
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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