Pathogenesis of endometriosis--current research
Abstract
Proliferative, secretory and menstrual endometrial cells of both the stroma and epithelium adhere to intact peritoneal mesothelium and mesothelial monolayers. Endometrial attachment to the mesothelium appears to occur rapidly (within 1 h) and transmesothelial invasion occurs between 1 and 18-24 h. These results demonstrate that the mesothelium is not a 'no-stick' surface and indicates that molecules present at the surface of the mesothelium are involved in the pathogenesis of the early endometriotic lesion. The inhibition of endometrial cell adherence to peritoneal mesothelium by hyaluronidase indicates that CD44-hyaluronan binding is at least one of the mechanisms involved in the pathogenesis of endometriosis. We believe that investigation of mesothelial cell adhesion molecules is central to understanding the pathogenesis of endometriosis.
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Th2 lymphocytes gain an advantage in women with endometriosis.
“According to literature data, Th2 lymphocytes gain an advantage in women with endometriosis [79].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [79]
Sampson observed tubal reflux of menstrual shedding at the time of menstruation, but never reported the early stage of endometrial attachment to the mesothelium and invasion as documented by Witz et al. in experimental conditions.
“It is important to note that although Sampson observed tubal reflux of menstrual shedding (7) at the time of menstruation, but never reported the early stage of endometrial attachment to the mesothelium and invasion as documented by Witz et al. (32) in experimental conditions.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [32]
Cites
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Smolarz, B., Szyłło, K., & Romanowicz, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910554 · Cited by 560 · see citing works
Pathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241 · see citing works
- Authors
- Witz, C. A., Allsup, K. T., Montoya-Rodriguez, I. A., Vaughan, S. L., Centonze, V. E., & Schenken, R. S.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Human Fertility
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 6
- Issue
- 1
- Pages
- 34-40
- ISSN
- 1464-7273 (ISSN-L)
- 1742-8149
- OpenAlex
- W2059799829
- Cited by
- 24
- References
- 22
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 2 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Fertility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis pathogenesis, peritoneal mesothelium, CD44, hyaluronic acid, hyaluronidase
- MeSH terms
- Cell Adhesion, Endometriosis, Epithelial Cells, Epithelium, Female, Humans, Hyaluronic Acid, Hyaluronoglucosaminidase, Menstruation, Peritoneum, Stromal Cells, Hyaluronan Receptors
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