Spironolactone in the treatment of polycystic ovary syndrome
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Charles Masayuki Kagawa passed away on 9 May 2015 at the age of 92. He is considered the father of SP [1]. From 1957, he studied a steroid compound (Aldactone-SC9420) which caused sodium depletion ...
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Administration of drugs with anti-androgenic activity improves insulin resistance.
“The administration of drugs with anti-androgenic activity improves insulin resistance [26].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [26]
Spironolactone requires at least 5-6 months of therapy to produce a subjective effect on hair loss.
“The effect on hair loss occurs over a longer period of time because the half-life of hair is very long and therefore at least 5–6 months of therapy are required to see a subjective effect [26].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [26]
Spironolactone has antiandrogen effects including androgen receptor blockade, aromatase stimulation, and partial blockade of androgen synthesis in gonads and adrenals.
“Spironolactone has several antiandrogen effects such as androgen receptor blockade, aromatase stimulation, and direct effect of partial blockade of androgen synthesis, not only in the gonads but also in the adrenals through a direct effect on ovarian and adrenal androgen synthesis [26,73].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [26]
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- Authors
- Armanini, D., Andrisani, A., Bordin, L., & Sabbadin, C.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Armanini, Decio
- Venue
- Expert Opinion on Pharmacotherapy
- Publisher
- Informa UK Limited
- Published
- 2016-07-29
- Volume
- 17
- Issue
- 13
- Pages
- 1713-1715
- ISSN
- 1465-6566 (ISSN-L)
- 1744-7666
- OpenAlex
- W2494277033
- Cited by
- 53
- References
- 18
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Opinion on Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- spironolactone, polycystic ovary syndrome, mineralocorticoid receptor antagonists, androgen deprivation therapy, sodium depletion
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