Effect of Aldosterone and Glycyrrhetinic Acid on the Protein Expression of PAI-1 and p22phox in Human Mononuclear Leukocytes
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Aldosterone excess can produce heart and kidney fibrosis, which seem to be related to a direct effect of aldosterone at the level of specific receptors. We report a direct, mineralocorticoid-mediated effect on the protein expression of two markers of oxidative stress after incubation of mononuclear leukocytes with 1 × 10−8m aldosterone (p22phox/β-actin = 1.38 ± 0.05 and PAI-1/β-actin = 1.80 ± 0.05). The same effect was also found with 3 × 10−5m glycyrrhetinic acid, the principal constituent of licorice root (p22phox/β-actin = 1.37 ± 0.97 and PAI-1/β-actin = 1.80 ± 0.04). The effect of both aldosterone and glycyrrhetinic acid is blocked by incubation with added 1 × 10−6m of receptor-antagonist canrenone. Canrenone alone did not show any effect. PAI-1 related protein was also found using 4 × 10−9m aldosterone. Incubations with 1 × 10−9m for 3 hours as well as 1 × 10−8m aldosterone for 5, 10, and 20 minutes were ineffective for both proteins. These data support the previous finding of an involvement of mononuclear leukocytes in the pathogenesis of the oxidative stress induced by hyperaldosteronism. In addition, the results confirm our previous data on a direct effect of glycyrrhetinic acid at the level of mineralocorticoid receptors.
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Incubation of lymphocytes with excess aldosterone increased protein expression of PAI 1 and p22phox, two markers of inflammation.
“subsequent studies confirmed that the incubation of lymphocytes with excess aldosterone increased the protein expression of PAI 1 and p22phox, two markers of inflammation [16].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [16]
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Rickard, A. J., Morgan, J., Tesch, G. H., Funder, J. W., Fuller, P. J., & Young, M. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.131110 · Cited by 302 · see citing works
Muñoz‐Durango, N., Fuentes, C., Castillo, A., González-Gómez, L. M., Vecchiola, A., Fardella, C., & Kalergis, A. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17070797 · Cited by 288 · see citing works
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Gilbert, K. C., & Brown, N. J. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283391989 · Cited by 161 · see citing works
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Kristanc, L., & Kreft, S. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.04.007 · Cited by 91 · see citing works
Jain, R., Hussein, M. A., Pierce, S., Martens, C., Shahagadkar, P., & Munirathinam, G. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106138 · Cited by 93 · see citing works
Queisser, N., & Schupp, N. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.011 · Cited by 77 · see citing works
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Feraco, A., Armani, A., Mammi, C., Fabbri, A., Rosano, G. M. C., & Caprio, M. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.012 · Cited by 53 · see citing works
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Dean, M., Murphy, B. T., & Burdette, J. E. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.013 · Cited by 56 · see citing works
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Park, Y. M., Lim, B. H., Touyz, R. M., & Park, J. B. (2008) · Journal of Korean Medical Science · doi:10.3346/jkms.2008.23.6.1039 · Cited by 34 · see citing works
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Ma, J., Albornoz, F., Yu, C., Byrne, D. W., Vaughan, D. E., & Brown, N. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000174327.53863.86 · Cited by 33 · see citing works
Athimulam, S., Lazik, N., & Bancos, I. (2019) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2019.08.003 · Cited by 31 · see citing works
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Self-citationCalò, L. A., Pagnin, E., Davis, P. A., Armanini, D., Mormino, P., Rossi, G. P., & Pessina, A. C. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346549 · Cited by 21 · see citing works
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Self-citationVecchiola, A., Fuentes, C., Barros, E., Martínez‐Aguayo, A., García, H., Allende, F. A., Solari, S., Olmos, R. I., Carvajal, C. A., Tapia-Castillo, A., et al. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz023 · Cited by 20 · see citing works
Parker, J., O'Brien, C. L., Yeoh, C., Gersh, F. L., & Brennecke, S. P. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061774 · Cited by 18 · see citing works
Armanini, D., Scaroni, C. M., Mattarello, M. J., Fiore, C., Albiger, N. M. E., & Sartorato, P. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345379 · Cited by 17 · see citing works
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Self-citationFogari, R., Derosa, G., Zoppi, A., Lazzari, P., D’Angelo, A., & Mugellini, A. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.874415 · Cited by 14 · see citing works
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Brown, N. J., Muldowney, J. A. S., & Vaughan, D. E. (2006) · Hypertension · doi:10.1161/01.hyp.0000202478.79587.1a · Cited by 9 · see citing works
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Self-citationNagelkirk, P. R., Franklin, B. A., Coughlin, A. M., Hassouna, H. I., Fink, G. D., Pivarnik, J. M., & Womack, C. J. (2007) · Preventive Cardiology · doi:10.1111/j.1520-037x.2007.06425.x · Cited by 3 · see citing works
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Rustamzadeh, A., Zamani, S., Heidarian, E., Ahmadi, R., Rahimi‐Madiseh, M., & Nouri, A. (2023) · Comparative Clinical Pathology · doi:10.1007/s00580-023-03473-2 · Cited by 2 · see citing works
Yagi, S., & Sata, M. (2011) · European Heart Journal Supplements · doi:10.1093/eurheartj/sur012 · Cited by 2 · see citing works
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Self-citationArmanini, D., Sabbadin, C., & Boscaro, M. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01500-z · Cited by 2 · see citing works
Self-citationArmanini, D., Calò, L. A., & Fiore, C. (2011) · Kidney International · doi:10.1038/ki.2011.362 · Cited by 2 · see citing works
Self-citationAldosterone-mediated endothelial remodeling and oxidative stress
Calò, L. A., & Armanini, D. (2005) · Kidney International · doi:10.1038/ki.2005.4496300 · Cited by 2 · see citing works
Self-citation
- Authors
- Calò, L. A., Zaghetto, F., Pagnin, E., Davis, P. A., de Mozzi, P., Sartorato, P., Martire, G., Fiore, C., & Armanini, D.
- Affiliations
- Department of Clinical and Experimental Medicine, Clinica Medica 4 (L.A.C., F.Z., E.P., P.D.M.), University of Padua, Padua 35100, Italy;
- University of Padua (IT)
- University of California, Davis (US)
- Corresponding author
- Armanini, Decio
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-04-01
- Volume
- 89
- Issue
- 4
- Pages
- 1973-1976
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1996601414
- Cited by
- 122
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 9 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- aldosterone, glycyrrhetinic acid, plasminogen activator inhibitor-1, p22phox, mononuclear leukocytes, mineralocorticoid receptor, oxidative stress, hyperaldosteronism, canrenone, licorice, fibrosis
- MeSH terms
- Adult, Aldosterone, Mineralocorticoid Receptor Antagonists, Canrenone, Dose-Response Relationship, Drug, Drug Synergism, Female, Glycyrrhetinic Acid, Humans, Leukocytes, Mononuclear, Male, NADPH Dehydrogenase, Phosphoproteins, Plasminogen Activator Inhibitor 1, NADPH Oxidases, Membrane Transport Proteins
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