Cited by 10Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAntioxidants, Aging, Portulaca oleracea

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come

Open access

Lewis, Caitlin J., de Grey, Aubrey D.·2024·Expert Opinion on Therapeutic Targets

DOI 10.1080/14728222.2024.2330425

Open this paper in CoChat — free account

Abstract

INTRODUCTION: Longevity research has matured to the point where significantly postponing age-related decline in physical and mental function is now achievable in the laboratory and foreseeable in the clinic. The most promising strategies involve rejuvenation, i.e. reducing biological age, not merely slowing its progression. AREAS COVERED: We discuss therapeutic strategies for rejuvenation and results achieved thus far, with a focus on in vivo studies. We discuss the implications of interventions which act on mean or maximum lifespan and those showing effects in accelerated disease models. While the focus is on work conducted in mice, we also highlight notable insights in the field from studies in other model organisms. EXPERT OPINION: Rejuvenation was originally proposed as easier than slowing aging because it targets initially inert changes to tissue structure and composition, rather than trying to disentangle processes that both create aging damage and maintain life. While recent studies support this hypothesis, a true test requires a panel of rejuvenation interventions targeting multiple damage categories simultaneously. Considerations of cost, profitability, and academic significance have dampened enthusiasm for such work, but it is vital. Now is the time for the field to take this key step toward the medical control of aging.

Integrity signals

Registry

Crossref · 10.1080/14728222.2024.2330425

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cited works that were retracted

Works this paper cites that were later retracted, from the retraction notices publishers deposit. Major when the notice came out before this paper was published.

1 of 1

1 retracted

RETRACTED: New intranasal and injectable gene therapy for healthy life extension
Jaijyan, D. K., Selariu, A., Cruz-Cosme, R., Tong, M., Yang, S., Stefa, A., Kekich, D., Sadoshima, J., Herbig, U., Tang, Q., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121499119 · Cited by 57
Retracted
The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · cited 1×
“In recent decades, the interest in CR has broadened to encompass small molecules known as CR mimetics, which in one or another way also induce gene expression and consequent metabolic and life-span changes overlapping those seen in CR, of which the standout example is rapamycin [10].”
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 3×
“…laboratory, especially in respect of interventions that ‘repair damage,’ i.e. restore the molecular and/or cellular structure and composition of one or more tissues toward that existing at a younger age; perhaps the most prominent such area has been the selective ablation of senescent cells [6].”
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers, A. J., Leverson, J. D., Boghaert, E. R., Ackler, S. L., Catron, N. D., Chen, J., Dayton, B. D., Ding, H., Enschede, S. H., Fairbrother, W. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3048 · Cited by 3,058
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,876 · cited 1×
“The choice to include a senolytic in combination studies was similarly straightforward – the field has grown exponentially in recent years following the unexpectedly wide-ranging effects of senescent cell ablation reported in early studies [6,45,46].”
The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.03.035 · Cited by 2,112
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
Rapamycin: one drug, many effects
Li, J., Kim, S. G., & Blenis, J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.001 · Cited by 1,287
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Zhu, Y., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., et al. (2016) · Aging Cell · doi:10.1111/acel.12445 · Cited by 1,148
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
Broxmeyer, H. E., Orschell, C. M., Clapp, D. W., Hangoc, G., Cooper, S. H., Plett, P. A., Liles, W. C., Li, X., Graham-Evans, B. E., Campbell, T., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041385 · Cited by 1,107
Senolytic CAR T cells reverse senescence-associated pathologies
Amor, C., Feucht, J., Leibold, J., Ho, Y.-J., Zhu, C., Alonso-Curbelo, D., Mansilla-Soto, J., Boyer, J. A., Li, X., Giavridis, T., et al. (2020) · Nature · doi:10.1038/s41586-020-2403-9 · Cited by 1,098
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,082
Calorie restriction, SIRT1 and metabolism: understanding longevity
Bordone, L., & Guarente, L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1616 · Cited by 1,038
The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake
Weindruch, R. H., Walford, R. L., Fligiel, S., & Guthrie, D. (1986) · Journal of Nutrition · doi:10.1093/jn/116.4.641 · Cited by 992
An aged immune system drives senescence and ageing of solid organs
Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature · doi:10.1038/s41586-021-03547-7 · Cited by 972
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
Wilson, W. H., O'Connor, O. A., Czuczman, M. S., LaCasce, A. S., Gerecitano, J. F., Leonard, J. P., Tulpule, A., Dunleavy, K., Xiong, H., Chiu, Y.-L., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70261-8 · Cited by 876
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796
The role of protein clearance mechanisms in organismal ageing and age-related diseases
Vı́lchez, D., Sáez, I., & Dillin, A. G. (2014) · Nature Communications · doi:10.1038/ncomms6659 · Cited by 710
Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
Gandhi, L., Camidge, D. R., Ribeiro de Oliveira, M., Bonomi, P., Gandara, D., Khaira, D., Hann, C. L., McKeegan, E. M., Litvinovich, E., Hemken, P. M., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.6208 · Cited by 603
druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico
Kadurin, A., Nikolenko, S., Khrabrov, K., Aliper, A., & Zhavoronkov, A. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00346 · Cited by 587
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence
Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100492 · Cited by 532 · cited 1×
“…of the most potent broad-spectrum senolytic drugs yet identified, its action protecting against renal fibrosis [53,54], reversing aspects of induced pulmonary fibrosis [55], reducing cardiac hypertrophy and fibrosis [56] and increasing survival time post myocardial-infarction in aged rodents [57].”
Rapalogs and mTOR inhibitors as anti-aging therapeutics
Lamming, D. W., Ye, L., Sabatini, D. M., & Baur, J. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64099 · Cited by 531
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
Tomás-Loba, A., Flores, I., Fernández-Marcos, P. J., Cayuela, M. L., Maraver, A., Tejera, A., Borrás, C., Matheu, A., Klatt, P., Flores, J. M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.034 · Cited by 484 · cited 1×
“…overexpression in mice would be pointless because most mouse cells express telomerase naturally, ectopic expression of telomerase in aged rodents has now been demonstrated by multiple groups to extend murine lifespan [14,89–91], and further, with no evidence of increased carcinogenesis [84,89,90].”
How does calorie restriction work?Preprint
Koubova, J., & Guarente, L. (2003) · Genes & Development · doi:10.1101/gad.1052903 · Cited by 458
Cell-Based Therapeutics: The Next Pillar of Medicine
Fischbach, M. A., Bluestone, J. A., & Lim, W. A. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005568 · Cited by 424
Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407
Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
Cai, Y., Zhou, H., Zhu, Y., Sun, Q., Ji, Y., Xue, A., Wang, Y., Chen, W., Yu, X., Wang, L., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0314-9 · Cited by 397
Telomere shortening rate predicts species life span
Whittemore, K., Vera, E., Martínez-Nevado, E., Sanpera, C., & Blasco, M. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902452116 · Cited by 373
A versatile drug delivery system targeting senescent cells
Muñoz‐Espín, D., Rovira, M., Galiana, I., Giménez, C., Lozano‐Torres, B., Paez‐Ribes, M., Llanos, S., Chaib, S., Muñoz‐Martín, M., Ucero, A. C., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809355 · Cited by 339
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
Devine, S. M., Vij, R., Rettig, M. P., Todt, L. M., McGlauchlen, K., Fisher, N. M., Devine, H., Link, D. C., Calandra, G., Bridger, G. J., et al. (2008) · Blood · doi:10.1182/blood-2007-12-130179 · Cited by 307
From in vitro Experiments to in vivo and Clinical Studies; Pros and Cons
Saeidnia, S., Manayi, A., & Abdollahi, M. R. (2016) · Current Drug Discovery Technologies · doi:10.2174/1570163813666160114093140 · Cited by 305
Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
González‐Gualda, E., Pàez‐Ribes, M., Lozano‐Torres, B., Macias, D., Wilson, J. R., González‐López, C., Ou, H., Mirón‐Barroso, S., Zhang, Z., Lérida‐Viso, A., et al. (2020) · Aging Cell · doi:10.1111/acel.13142 · Cited by 303
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice
Suda, M., Shimizu, I., Katsuumi, G., Yoshida, Y., Hayashi, Y., Ikegami, R., Matsumoto, N., Yoshida, Y., Mikawa, R., Katayama, A., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00151-2 · Cited by 290
High throughput screening in drug discovery
Carnero, A. (2006) · Clinical & Translational Oncology · doi:10.1007/s12094-006-0048-2 · Cited by 290
ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development
Cang, S., Iragavarapu, C., Savooji, J., Song, Y., & Liu, D. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0224-3 · Cited by 289
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
He, Y., Zhang, X., Chang, J., Kim, H.-N., Zhang, P., Wang, Y., Khan, S., Liu, X., Zhang, X., Lv, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15838-0 · Cited by 280
Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial
Rockwood, K. J. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.5.589 · Cited by 277
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction
Walaszczyk, A., Dookun, E., Redgrave, R., Tual‐Chalot, S., Victorelli, S., Spyridopoulos, I., Owens, A., Arthur, H. M., Passos, J. F., & Richardson, G. D. (2019) · Aging Cell · doi:10.1111/acel.12945 · Cited by 250
Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice
Jin Bing, P. A. N., Li, D., Xu, Y., Zhang, J., Wang, Y., Chen, M., Lin, S., Huang, L., Chung, E. J., Citrin, D. E., et al. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.02.216 · Cited by 250
The Rate of Increase of Short Telomeres Predicts Longevity in Mammals
Vera, E., de Jesus, B. B., Foronda, M., Flores, J. M., & Blasco, M. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.023 · Cited by 228
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
Mylonas, K. J., O’Sullivan, E. D., Humphries, D., Baird, D. P., Docherty, M.-H., Neely, S. A., Krimpenfort, P. J., Melk, A., Schmitt, R., Ferreira-Gonzalez, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb0203 · Cited by 219
Time to Talk SENS: Critiquing the Immutability of Human Aging
de Grey, A. D. N. J., Ames, B. N., Andersen, J. K., Bartke, A., Campisi, J., Heward, C. B., McCarter, R., & Stock, G. B. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02115.x · Cited by 189
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Muñoz-Lorente, M. A., Cano-Martin, A. C., & Blasco, M. A. (2019) · Nature Communications · doi:10.1038/s41467-019-12664-x · Cited by 184
Longevity, aging and rapamycin
Ehninger, D., Neff, F., & Xie, K. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1677-1 · Cited by 183
Galactose‐modified duocarmycin prodrugs as senolytics
Guerrero, A., Guiho, R., Herranz, N., Uren, A., Withers, D. J., Martínez‐Barbera, J. P., Tietze, L. F., & Gil, J. (2020) · Aging Cell · doi:10.1111/acel.13133 · Cited by 172
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes
Morales, J. O., Fathe, K., Brunaugh, A. D., Ferrati, S., Li, S., Montenegro-Nicolini, M., Mousavikhamene, Z., McConville, J. T., Prausnitz, M. R., & Smyth, H. D. C. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0054-z · Cited by 159
Acarbose improves health and lifespan in aging HET3 mice
Harrison, D. E., Strong, R., Alavez, S., Astle, C. M., DiGiovanni, J., Fernández, E., Flurkey, K., Garratt, M., Gelfond, J., Javors, M. A., et al. (2019) · Aging Cell · doi:10.1111/acel.12898 · Cited by 140
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
Povedano, J. M., Martinez, P., Serrano, R., Tejera, Á., Gómez-López, G., Bobadilla, M., Flores, J. M., Bosch, F., & Blasco, M. A. (2018) · eLife · doi:10.7554/elife.31299 · Cited by 139
Growth Hormone and Aging: Updated Review
Bartke, A. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180018 · Cited by 137
Increased fidelity of protein synthesis extends lifespan
Martinez-Miguel, V. E., Lujan, C., Espie--Caullet, T., Martinez-Martinez, D., Moore, S., Backes, C., Gonzalez, S., Galimov, E. R., Brown, A. E. X., Halic, M., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.017 · Cited by 137
Phenotypes in mTERT+/− and mTERT−/− Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase
Strong, M. A., Vidal-Cardenas, S. L., Karim, B. O., Yu, H. M., Guo, N., & Greider, C. W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05312-11 · Cited by 136
Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia
Bär, C., Povedano, J. M., Serrano, R., Benitez-Buelga, C., Popkes, M., Formentini, I., Bobadilla, M., Bosch, F., & Blasco, M. A. (2016) · Blood · doi:10.1182/blood-2015-08-667485 · Cited by 116
Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity
Vera, E., Bernardes de Jesus, B., Foronda, M., Flores, J. M., & Blasco, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053760 · Cited by 111
Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice
Martínez-Cisuelo, V., Gómez, J., García-Junceda, I., Naudí, A., Cabré, R., Mota‐Martorell, N., Lopez‐Torres, M., González-Sánchez, M., Pamplona, R., & Barja, G. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.08.002 · Cited by 111
What are the drugs of the future?
Ngo, H., & Garneau‐Tsodikova, S. (2018) · MedChemComm · doi:10.1039/c8md90019a · Cited by 111
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
Kuribayashi, W., Oshima, M., Itokawa, N., Koide, S., Nakajima-Takagi, Y., Yamashita, M., Yamazaki, S., Rahmutulla, B., Miura, F., Ito, T., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20192283 · Cited by 111
Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice
Tarantini, S., Balasubramanian, P., DelFavero, J., Csípő, T., Yabluchanskiy, A., Kiss, T., Nyúl‐Tóth, Á., Mukli, P., Tóth, P., Ahire, C., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00440-z · Cited by 103
Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice
Sato, S., Kawamata, Y., Takahashi, A., Imai, Y., Hanyu, A., Okuma, A., Takasugi, M., Yamakoshi, K., Sorimachi, H., Kanda, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8035 · Cited by 77
Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice
Fielder, E., Wan, T., Alimohammadiha, G., Ishaq, A., Low, E., Weigand, B. M., Kelly, G., Parker, C., Griffin, B., Jurk, D., et al. (2022) · eLife · doi:10.7554/elife.75492 · Cited by 76
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice
Strong, R., Miller, R. A., Cheng, C. J., Nelson, J. F., Gelfond, J., Allani, S. K., Diaz, V., Dorigatti, A. O., Dorigatti, J., Fernandez, E., et al. (2022) · Aging Cell · doi:10.1111/acel.13724 · Cited by 76
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study
Fielding, R. A., Atkinson, E. J., Aversa, Z., White, T. A., Heeren, A. A., Achenbach, S. J., Mielke, M. M., Cummings, S. R., Pahor, M., Leeuwenburgh, C., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00685-2 · Cited by 75
Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice
Jia, K., Dai, Y., Liu, A., Li, X., Wu, L., Lu, L., Bao, Y., & Jin, Q. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000878 · Cited by 71
Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span
Kumar, S., Dietrich, N., & Kornfeld, K. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005866 · Cited by 63
WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans
Pitt, J. N., Strait, N. L., Vayndorf, E. M., Blue, B. W., Tran, C., Davis, B. E. M., Huang, K., Johnson, B., Lim, J. K., Liu, S. N., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00124-9 · Cited by 57
In Silico Pharmacology: Computer-Aided Methods Could Transform Drug Development
Shekhar, C. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.05.001 · Cited by 56
Senescence induces fundamental changes in the secretome of mesenchymal stromal cells (MSCs): implications for the therapeutic use of MSCs and their derivates
Adem, Y., Galderisi, U., & Alessio, N. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1148761 · Cited by 55
Repurposing FDA-approved drugs for anti-aging therapies
Snell, T. W., Johnston, R. K., Srinivasan, B., Zhou, H., Gao, M., & Skolnick, J. (2016) · Biogerontology · doi:10.1007/s10522-016-9660-x · Cited by 46
Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet
Leontieva, O. V., Paszkiewicz, G., Demidenko, Z. N., & Blagosklonny, M. V. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.202 · Cited by 44
The Unfortunate Influence of the Weather on the Rate of Ageing: Why Human Caloric Restriction or Its Emulation May Only Extend Life Expectancy by 2–3 Years
de Grey, A. D. N. J. (2005) · Gerontology · doi:10.1159/000082192 · Cited by 43
Repurposing drugs to fight aging: The difficult path from bench to bedside
Vaiserman, A. M., Koliada, A. K., Lushchak, O. V., & Castillo, M. J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21773 · Cited by 42
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells
Morsli, S., Doherty, G. J., & Muñoz‐Espín, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111618 · Cited by 41
A senolysis-based theragnostic prodrug strategy towards chronic renal failure
Song, Y., Li, X., Shi, D., Sun, T., Liu, W., Li, X., Qiao, S., Chen, X., Guo, Y., & Li, J. (2022) · Chemical Science · doi:10.1039/d2sc03525a · Cited by 41
Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice
Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J., Gorena, K. M., Cheng, C. J. A., Li, Y., Nelson, J. F., et al. (2020) · Aging Cell · doi:10.1111/acel.13110 · Cited by 37
A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia
Tezze, C., Amendolagine, F. I., Nogara, L., Baraldo, M., Ciciliot, S., Arcidiacono, D., Zaramella, A., Masiero, G., Ferrarese, G., Realdon, S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.168787 · Cited by 36
The Unexpected Outcomes of Anti-Aging, Rejuvenation, and Life Extension Studies: An Origin of Modern Therapies
Stambler, I. (2014) · Rejuvenation Research · doi:10.1089/rej.2013.1527 · Cited by 33
Small molecule drugs with immunomodulatory effects in cancer
Murphy, A. G., & Zheng, L. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1057363 · Cited by 33
Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology
Herrera, J. J., Louzon, S., Pifer, K., Leander, D. C., Merrihew, G. E., Park, J. H., Szczesniak, K., Whitson, J. D., Wilkinson, J. E., Fiehn, O., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137474 · Cited by 31
Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
Kovina, M. V., Karnaukhov, A. V., Krasheninnikov, M. E., Kovin, A. L., Gazheev, S. T., Sergievich, L. A., Karnaukhova, E. V., Bogdanenko, E. V., Balyasin, M. V., Khodarovich, Y. M., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00310 · Cited by 24
The Ercc 1-/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions
Wong, A., Kieu, T., & Robbins, P. D. (2020) · Aging · doi:10.18632/aging.202321 · Cited by 20
Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan
Kaur, P., Otgonbaatar, A., Ramamoorthy, A., Chua, E. H. Z., Harmston, N., Gruber, J., & Tolwinski, N. S. (2022) · Aging · doi:10.18632/aging.204347 · Cited by 20
Effect on lifespan of high yield non-myeloablating transplantation of bone marrow from young to old mice
Kovina, M. V., Zuev, V. A., Kagarlitskiy, G. O., & Khodarovich, Y. M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00144 · Cited by 19
The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery
Lee, M. B., Blue, B. W., Muir, M., & Kaeberlein, M. R. (2023) · GeroScience · doi:10.1007/s11357-023-00867-6 · Cited by 16
Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice
Herrera, J. J., Pifer, K., Louzon, S., Leander, D. C., Fiehn, O., Day, S. M., Miller, R. A., & Garratt, M. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac221 · Cited by 15
Targeted senolytic prodrug is well tolerated and results in amelioration of frailty, muscle regeneration and cognitive functions in geriatric micePreprint
Doan, L., Paine, P., Tran, C., Parsons, B., Hiller, A., Joshua, I., Collaco, N., Vitari, A., de Morrée, A., Ishak, H. D., et al. (2020) · doi:10.21203/rs.3.rs-92962/v1 · Cited by 14
An Updated Overview on the Role of Small Molecules and Natural Compounds in the “Young Science” of Rejuvenation
Ribaudo, G., & Gianoncelli, A. (2023) · Antioxidants · doi:10.3390/antiox12020288 · Cited by 14
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence
Burnaevskiy, N., Oshima, J., & Mendenhall, A. (2022) · GeroScience · doi:10.1007/s11357-022-00709-x · Cited by 10
Small molecules vs biologics
Poduval, P., Parsekar, S., & Meena, S. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15232-0.00001-1 · Cited by 9

Sorted by citations

Epigenetic Clocks and EpiScore for Preventive Medicine: Risk Stratification and Intervention Models for Age-Related Diseases
Yamada, H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103604 · Cited by 22
Targeting multiple hallmarks of mammalian aging with combinations of interventions
Panchin, A. Y., Ogmen, A., Blagodatski, A. S., Egorova, A., Batin, M., & Glinin, T. S. (2024) · Aging · doi:10.18632/aging.206078 · Cited by 22
Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin
Barzilai, D. A. (2025) · Aging · doi:10.18632/aging.206189 · Cited by 4
The Hallmarks of aging: Paradigms and scientific progress
García‐Barranquero, P., & Luque, V. J. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103181 · Cited by 3
In-silico evaluation of aging-related interventions using omics data and predictive modeling
Fuellen, G., Palmer, D. H., Fruijtier-Pölloth, C., & Avelar, R. A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102777 · Cited by 2

See all 10

Authors: Lewis, C. J., & de Grey, A. D.
Affiliations: Longevity Escape Velocity Foundation, San Francisco, CA, USA
Corresponding author: de Grey, Aubrey D.
ORCID: Lewis, Caitlin J.
de Grey, Aubrey D.
Venue: Expert Opinion on Therapeutic Targets
Publisher: Informa UK Limited
Published: 2024-03-18
Volume: 28
Issue: 6
Pages: 501-511
ISSN: 1472-8222 (ISSN-L)
1744-7631
DOI: 10.1080/14728222.2024.2330425
OpenAlex: W4392749258
Semantic Scholar: 7037a384342019ff5448d717e80514743f05331c
Cited by: 10
References: 94
Citations by year: 2026: 4 · 2025: 3 · 2024: 3
FWCI: 0.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Expert Opinion on Therapeutic Targets (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Longevity Escape Velocity (LEV) Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords: rejuvenation, aging, longevity, biological age, age-related decline, lifespan extension, anti-aging interventions, mice, model organisms
MeSH terms: Aging, Animals, Disease Models, Animal, Geriatrics, Humans, Longevity, Rejuvenation, Rodentia, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Cited works that were retracted

Citations

Cites

Cited by

Related

Metadata

Record

About these checks