The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
An update on diagnostic and prognostic biomarkers for traumatic brain injury
Open accessAbstract
INTRODUCTION: Traumatic brain injury (TBI) is a major worldwide neurological disorder of epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms of TBI. Encouragingly, there are emerging data showing that biofluid-based TBI biomarker tests have the potential to diagnose the presence of TBI of different severities including concussion, and to predict outcome. Areas covered: The authors provide an update on the current knowledge of TBI biomarkers, including protein biomarkers for neuronal cell body injury (UCH-L1, NSE), astroglial injury (GFAP, S100B), neuronal cell death (αII-spectrin breakdown products), axonal injury (NF proteins), white matter injury (MBP), post-injury neurodegeneration (total Tau and phospho-Tau), post-injury autoimmune response (brain antigen-targeting autoantibodies), and other emerging non-protein biomarkers. The authors discuss biomarker evidence in TBI diagnosis, outcome prognosis and possible identification of post-TBI neurodegernative diseases (e.g. chronic traumatic encephalopathy and Alzheimer's disease), and as theranostic tools in pre-clinical and clinical settings. Expert commentary: A spectrum of biomarkers is now at or near the stage of formal clinical validation of their diagnostic and prognostic utilities in the management of TBI of varied severities including concussions. TBI biomarkers could serve as a theranostic tool in facilitating drug development and treatment monitoring.
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1 retracted
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Cited by
Nelson, L. D., Temkin, N. R., Dikmen, S., Barber, J., Giacino, J. T., Yuh, E., Levin, H. S., McCrea, M. A., Stein, M. B., Mukherjee, P., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1313 · Cited by 451
Self-citationBile acid signaling in neurodegenerative and neurological disorders
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Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders
Cohen, J., Mathew, A., Dourvetakis, K. D., Sanchez-Guerrero, E., Pangeni, R. P., Gurusamy, N., Aenlle, K. K., Ravindran, G., Twahir, A., Isler, D., et al. (2024) · Cells · doi:10.3390/cells13060511 · Cited by 103
Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury
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LoBue, C., Munro, C., Schaffert, J., Didehbani, N., Hart, Batjer, H., & Cullum, C. M. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-190028 · Cited by 86
Metadata
- Authors
- Wang, K. K., Yang, Z., Zhu, T., Shi, Y., Rubenstein, R., Tyndall, J. A., & Manley, G. T.
- Venue
- Expert Review of Molecular Diagnostics
- Publisher
- Informa UK Limited
- Published
- 2018-01-23
- Volume
- 18
- Issue
- 2
- Pages
- 165-180
- ISSN
- 1473-7159 (ISSN-L)
- 1744-8352
- OpenAlex
- W2789827414
- Cited by
- 542
- References
- 191
- FWCI
- 28.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, K. K., Yang, Z., Zhu, T., Shi, Y., Rubenstein, R., Tyndall, J. A., & Manley, G. T. (2018). An update on diagnostic and prognostic biomarkers for traumatic brain injury. Expert Review of Molecular Diagnostics. https://doi.org/10.1080/14737159.2018.1428089
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
