Long-term safety of approved biologics for ulcerative colitis
Abstract
INTRODUCTION: Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) affecting the large intestine and carrying a heavy burden of morbidity for patients. Conventional treatment is based on mesalamine, corticosteroids, and immunosuppressants. In the last two decades, biologic therapies have revolutionized the treatment of UC, increasing the number of therapeutic options and providing better disease control. AREAS COVERED: Most biologics have been approved in recent years and long-term data are still scarce. The aim of this review is to summarize safety data on long-term use of biologics in ulcerative colitis. The authors searched the literature up to May 2020 for studies assessing biological drugs' safety in UC with a follow-up longer than one year and present the key findings. EXPERT OPINION: Biologics long-term safety is consistent with what expected from shorter term studies and no main new concerns emerged from longer follow-up. Real world experience is consistent with clinical trials data. Although comparisons are difficult, safety profiles are not equal among different biologics.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Ungaro, R. C., Mehandru, S., Allen, P. B., Peyrin‐Biroulet, L., & Colombel, J. (2016) · The Lancet · doi:10.1016/s0140-6736(16)32126-2 · Cited by 3,659 · see citing works
Self-citationFord Alexander, C., Paul, M., Hanauer Steven, B., 谭蓓, & Dong, W. Z. (2001) · Cited by 3,021 · see citing works
Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis
Feagan, B. G., Rutgeerts, P. J., Sands, B. E., Hanauer, S. B., Colombel, J., Sandborn, W. J., Assche, G. V., Axler, J. L., Kim, H. J., Danese, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215734 · Cited by 2,892 · see citing works
Self-citationAbraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712 · see citing works
Harbord, M., Eliakim, R., Bettenworth, D., Karmiris, K., Katsanos, K., Kopylov, U., Kucharzik, T., Molnár, T., Raine, T., Sebastian, S., et al. (2017) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjx009 · Cited by 1,180 · see citing works
The safety of vedolizumab for ulcerative colitis and Crohn's disease
Colombel, J., Sands, B. E., Rutgeerts, P. J., Sandborn, W. J., Danese, S., D’Haens, G., Panaccione, R., Loftus, E. V., Sankoh, S., Fox, I. H., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-311079 · Cited by 805 · see citing works
Self-citationVedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis
Sands, B. E., Peyrin‐Biroulet, L., Loftus, E. V., Danese, S., Colombel, J., Törüner, M., Jonaitis, L. V., Abhyankar, B., Chen, J., Rogers, R., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1905725 · Cited by 759 · see citing works
Self-citationKirchgesner, J., Lemaître, M., Carrat, F., Zureik, M., Carbonnel, F., & Dray‐Spira, R. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.012 · Cited by 610 · see citing works
ACG clinical guideline: Preventive care in inflammatory bowel disease
Farraye, F. A., Melmed, G. Y., Lichtenstein, G. R., & Kane, S. V. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.537 · Cited by 473 · see citing works
Bonovas, S., Fiorino, G., Allocca, M., Lytras, T., Nikolopoulos, G. K., Peyrin‐Biroulet, L., & Danese, S. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.04.039 · Cited by 386 · see citing works
Self-citationSandborn, W. J., Baert, F., Danese, S., Krznarić, Ž., Kobayashi, T., Yao, X., Chen, J., Rosario, M., Bhatia, S., Kisfalvi, K., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.08.027 · Cited by 333 · see citing works
Self-citationInduction and maintenance treatment of inflammatory bowel disease: A comprehensive review
Jeong, D. Y., Kim, S., Son, M. J., Son, C. Y., Kim, J. Y., Kronbichler, A., Lee, K. H., & Shin, J. I. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.002 · Cited by 215 · see citing works
Long-term Infliximab Maintenance Therapy for Ulcerative Colitis: The ACT-1 and -2 Extension Studies
Reinisch, W., Sandborn, W. J., Rutgeerts, P. J., Feagan, B. G., Rachmilewitz, D., Hanauer, S. B., Lichtenstein, G. R., de Villiers, W. J. S., BLANK, M. A., Lang, Y., et al. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21697 · Cited by 208 · see citing works
Jung, Y. S., Park, D. I., Kim, Y. H., Lee, J. H., Seo, P. J., Cheon, J. H., Kang, H. W., & Kim, J. W. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12997 · Cited by 175 · see citing works
Kohn, A., Daperno, M., Armuzzi, A., Cappello, M., Biancone, L., Orlando, A., Viscido, A., Annese, V., Riegler, G., Meucci, G., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03415.x · Cited by 169 · see citing works
Colombel, J., Sandborn, W. J., Ghosh, S. K., Wolf, D. C., Panaccione, R., Feagan, B. G., Reinisch, W., Robinson, A. M., Lazar, A., Kron, M., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.242 · Cited by 166 · see citing works
Current and Emerging Biologics for Ulcerative Colitis
Park, S. C., & Jeen, Y. T. (2014) · Gut and Liver · doi:10.5009/gnl14226 · Cited by 134 · see citing works
Goll, G. L., Jørgensen, K. K., Sexton, J., Olsen, I. C., Bolstad, N., Haavardsholm, E. A., Lundin, K. E. A., Tveit, K. S., Lorentzen, M., Berset, I. P., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12880 · Cited by 123 · see citing works
Gies, N., Kroeker, K. I., Wong, K., & Fedorak, R. N. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04380.x · Cited by 103 · see citing works
Chaparro, M., Garre, A., Ricart, E., Iborra, M., Mesonero, F., Vera, I., Riestra, S., García-Sánchez, V., Castro, M. L. D., Martín‐Cardona, A., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14930 · Cited by 103 · see citing works
Burmester, G. R., Gordon, K. B., Rosenbaum, J. T., Arikan, D., Lau, W., Li, P., Faccin, F. J., & Panaccione, R. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01145-8 · Cited by 94 · see citing works
Positioning Therapies in Ulcerative Colitis
Danese, S., Fiorino, G., & Peyrin‐Biroulet, L. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.01.017 · Cited by 83 · see citing works
Self-citationFeagan, B. G., Sandborn, W. J., Colombel, J., Byrne, S. O., Khalid, J. M., Kempf, C., Geransar, P., Bhayat, F., & Rubin, D. T. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy125 · Cited by 81 · see citing works
Taxonera, C., Rodríguez, C., Bertoletti, F., Menchen, L. A., Arribas, J., Sierra, M., Arias, L., Martínez-Montiel, P., Juan, A. J., Iglesias, E. L., et al. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001144 · Cited by 79 · see citing works
Waljee, A. K., Higgins, P., Jensen, C. B., Villumsen, M., Cohen‐Mekelburg, S., Wallace, B. I., Berinstein, J. A., Allin, K. H., & Jess, T. (2019) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30362-0 · Cited by 73 · see citing works
Colombel, J., Sandborn, W. J., Reinisch, W., Peyrin‐Biroulet, L., Panaccione, R., Rutgeerts, P., Hanauer, S. B., Ghosh, S. K., Assche, G. V., Robinson, A. M., et al. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14420 · Cited by 54 · see citing works
Self-citationSafety of biological therapies in ulcerative colitis: An umbrella review of meta-analyses
Bonovas, S., Pantavou, K. G., Evripidou, D., Bastiampillai, A. J., Nikolopoulos, G. K., Peyrin‐Biroulet, L., & Danese, S. (2018) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2018.05.005 · Cited by 53 · see citing works
Self-citationCard, T. R., Ungaro, R. C., Bhayat, F., Blake, A., Hantsbarger, G. L., & Travis, S. P. L. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15538 · Cited by 53 · see citing works
Zhou, H., Guo, B., Lufumpa, E., Li, X., Chen, L., Meng, X. L., & Li, B. (2020) · Immunological Investigations · doi:10.1080/08820139.2020.1714650 · Cited by 45 · see citing works
Sánchez‐Hernandez, J. G., Rebollo, N., Martín‐Suárez, A., Calvo, M. V. M., & Muñoz, F. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14229 · Cited by 42 · see citing works
Gibson, P. R., Feagan, B. G., Sandborn, W. J., Marano, C. W., Strauss, R. S., Johanns, J., Padgett, L., Collins, J. F., Tarabar, D. K., Hebzda, Z., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.24 · Cited by 41 · see citing works
Pantavou, K. G., Yiallourou, A., Piovani, D., Evripidou, D., Danese, S., Peyrin‐Biroulet, L., Bonovas, S., & Nikolopoulos, G. K. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619883566 · Cited by 37 · see citing works
Self-citationReinisch, W., Gibson, P. R., Sandborn, W. J., Feagan, B. G., Strauss, R. S., Johanns, J., Padgett, L., Adedokun, O. J., Colombel, J., Collins, J. F., et al. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy079 · Cited by 35 · see citing works
A Simplified Algorithm for the Management of Hepatitis C Infection.
Dieterich, D. T. (2019) · PubMed Central · Cited by 35 · see citing works
Biosimilars of adalimumab: the upcoming challenge in IBD
Fiorino, G., Gilardi, D., Correale, C., Furfaro, F., Roda, G., Loy, L., ARGOLLO, M. C., Allocca, M., Peyrin‐Biroulet, L., & Danese, S. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1564033 · Cited by 30 · see citing works
Self-citationKim, N. H., Lee, J. H., Hong, S. N., Yoon, H., Kang, H. W., Lee, S., Im, J. P., Cha, J. M., Eun, C. S., Kim, J. W., et al. (2019) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14645 · Cited by 29 · see citing works
Feagan, B. G., Bhayat, F., Khalid, J. M., Blake, A., & Travis, S. P. L. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy047 · Cited by 27 · see citing works
Effectiveness and safety of adalimumab to treat outpatient ulcerative colitis
Tursi, A., Elisei, W., Faggiani, R., Allegretta, L., Valle, N. D., Forti, G., Franceschi, M., Ferronato, A., Gallina, S., Larussa, T., et al. (2018) · Medicine · doi:10.1097/md.0000000000011897 · Cited by 24 · see citing works
Moćko, P., Kawalec, P., & Pilc, A. (2016) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1785 · Cited by 23 · see citing works
Veloz, M. F. G., Jiménez, M. B., Delgado, T. V., Laria, L. C., Pérez, B. M., Amarillo, R. P., Bohórquez, V. M., Álvarez, Á. C., Vilches‐Arenas, Á., & Argüelles‐Arias, F. (2019) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284819858052 · Cited by 18 · see citing works
Panés, J., Lindsay, J. O., Teich, N., Lindgren, S. C., Colombel, J., Cornillie, F. J., Flynn, H. A., Huyck, S. B., Stryszak, P., Yao, R., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz048 · Cited by 14 · see citing works
Suarez, C. P., Webb, K., Persad, N., Sercombe, J., Tyler, E. D., & Klimova, K. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz203.602 · Cited by 4 · see citing works
Yzet, C., Tse, S., Kayal, M., Hirten, R. P., & Colombel, J. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190308102021 · Cited by 3 · see citing works
Danese, S., Panaccione, R., Peyrin‐Biroulet, L., Marano, C. W., O’Brien, C., Zhang, H., Zhou, Y., Johanns, J., Scherl, E., Leong, R. W. L., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz203.577 · Cited by 3 · see citing works
Self-citationSands, B. E., Abreu, M. T., Leong, R. W. L., Marano, C. W., O’Brien, C., Zhang, H., Zhou, Y., Johanns, J., Rowbotham, D. S., Hisamatsu, T., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz203.693 · Cited by 2 · see citing works
Self-citationSands, B. E., Sandborn, W. J., Panaccione, R., O’Brien, C. D., Zhang, H., Johanns, J., Zhou, Y., Peyrin‐Biroulet, L., Scherl, E., Leong, R. W. L., et al. (2020) · Gastroenterology · doi:10.1016/s0016-5085(20)33672-6 · Cited by 2 · see citing works
Self-citationPanaccione, R., Sandborn, W. J., Sands, B. E., Marano, C. W., O’Brien, C. D., Zhang, H., Johanns, J. R., Zhou, Y., Peyrin‐Biroulet, L., Hisamatsu, T., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz203.051 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Emerging issues in probiotic safety: 2023 perspectives
Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481 · see citing works
“A literature review in this area revealed such studies have follow-ups that range from 16 to (at most) approximately 24 months stratified by collecting reports of AEs and serious AEs while monitoring and connecting to various other outcomes.(99) Probiotics, which are often sold as supplements and not as drugs (live bi…”
BackgroundOlivera, P. A., Zuily, S., Kotze, P. G., Regnault, V., Awadhi, S. A., Bossuyt, P. J., Gearry, R. B., Ghosh, S. K., Kobayashi, T., Lacolley, P. J., et al. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00492-8 · Cited by 154 · see citing works
Self-citationRubin, D. T., Allegretti, J. R., Panés, J., Shipitofsky, N. L., Yarandi, S., Huang, K. G., Germinaro, M., Wilson, R., Zhang, H., Johanns, J. R., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01927-5 · Cited by 118 · see citing works
Self-citationNing, L., Ye, N., Bai, Y., Miao, Z., Cao, T., Lu, W., Xu, D., Tan, C., Xu, Y., & Yan, J. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01361-w · Cited by 19 · see citing works
“The conventional modalities for UC treatment include the administration of mesalamine, corticosteroids, and immunosuppressants [4].”
The oft-overlooked cardiovascular complications of inflammatory bowel disease
Massironi, S., Mulinacci, G., Gallo, C., Viganò, C., Fichera, M., Villatore, A., Peretto, G., & Danese, S. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2174971 · Cited by 17 · see citing works
“Post-marketing safety reports show no increased risk of arterial events in patients with IBD treated with either vedolizumab or ustekinumab [122,123].”
BackgroundSelf-citationNicolò, S., Faggiani, I., Errico, C., D’Amico, F., Parigi, T. L., Danese, S., & Ungaro, F. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2024.2400300 · Cited by 12 · see citing works
“The availability of biosimilars of both IFX and ADL adds to their cost-effectiveness and makes them among the most prescribed advanced treatments for both UC and CD [65].”
Self-citationZhong, Y., Xiao, Q., Li, S., Chen, L., Long, J., Fang, W., Yu, F., Huang, J., Zhao, H., & Liu, D. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154091 · Cited by 12 · see citing works
Huang, J., Zhong, Y., Cheng, N., Zhang, Z., Huang, L., Song, L., Cheng, S., Zhao, H., & Liu, D. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156035 · Cited by 10 · see citing works
The use of ileal pouch–anal anastomosis in patients with ulcerative colitis from 2009 to 2018
Kröner, P. T., Merchea, A., Colibaseanu, D., Picco, M. F., Farraye, F. A., & Stocchi, L. (2021) · Colorectal Disease · doi:10.1111/codi.15985 · Cited by 10 · see citing works
“ber of other biological agents have been introduced in the treatment of UC, including adalimumab, golimumab, vedolizumab, tofacitinib and most recently ustekinumab [18].”
BackgroundComparative efficacy of pharmacologic interventions in ulcerative colitis: a network meta analysis
Khan, A. U., Ali, M., & Wahab, M. A. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01723-z · Cited by 7 · see citing works
“These include tumor necrosis factor (TNF-α) inhibitors, such as infliximab and adalimumab which were among the first biologics to gain approval and show efficacy in both inducing and maintaining remission (D’Amico et al. 2020; Danese et al. 2015; Fausel et al. 2015).”
Chen, B., Ye, B. D., Cao, Q., Hirai, F., Saruta, M., Chen, M., Pelak, S., Shipitofsky, N. L., Ye, M., Herr, K. J., et al. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.17036 · Cited by 7 · see citing works
“The available conventional and advanced UC therapeutics can be limited by nonresponse to induction, loss of benefit over time, and adverse events (e.g., infection risk) [16–18].”
Marín‐Jiménez, I., Carpio, D., Hernández, V., Muñoz, F., Zatarain‐Nicolás, E., Zabana, Y., Mañosa, M., Rodríguez‐Moranta, F., Acosta, M. B., & Casbas, A. G. (2025) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2025.502314 · Cited by 6 · see citing works
Parigi, T. L., Allocca, M., Furfaro, F., D’Amico, F., Zilli, A., Buono, A. D., Gabbiadini, R., Bonovas, S., Armuzzi, A., Danese, S., et al. (2023) · Cancers · doi:10.3390/cancers15245754 · Cited by 5 · see citing works
Self-citationPetrov, V. I., Ryazanova, A. Y., Ponomareva, A. V., Shatalova, O. V., & Levina, Y. V. (2022) · Pharmacy & Pharmacology · doi:10.19163/2307-9266-2022-10-2-198-206 · Cited by 5 · see citing works
Could small molecules be used in combination with biologics for inflammatory bowel disease?
D’Amico, F., Danese, S., & Fiorino, G. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2104713 · Cited by 5 · see citing works
Self-citationGuan, X., Han, D., Sha, H., Yao, M., Zhang, J., Zhang, G., Wu, Y., Su, D., & Yang, Q. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211203 · Cited by 4 · see citing works
Marín‐Jiménez, I., Carpio, D., Hernández, V., Muñoz, F., Zatarain‐Nicolás, E., Zabana, Y., Mañosa, M., Rodríguez‐Moranta, F., Acosta, M. B., & Gutiérrez, A. (2024) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2024.502314 · Cited by 6 · see citing works
Pulmonary Manifestations of IBD: Case Report and Review of the Literature
Herling, A., Perluk, T. M., Freund, O., Maharshak, N., & Cohen, N. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185401 · Cited by 4 · see citing works
Lee, S., Ehrlich, A. C., Pellanda, P., Kaiser, C. J., Todd, K., Moses, R., & Walsh, A. J. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003407 · Cited by 3 · see citing works
“Long-term studies validated these observations and revealed minimal disparities between real-world experiences and clinical trial outcomes (11).”
Zhang, J., Wang, C., Wu, X., & Lin, Y. (2025) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2025.100337 · Cited by 1 · see citing works
“( D ’ Amico et al., 2020) Some patients rely on prolonged medication to manage inflammation and alleviate symptoms, while severe cases may require surgical intervention to remove affected segments of the colon.”
Almasri, H., Ismail, A. S., Khataniar, H., Butt, M. A., Karna, R., Bassett, J. T., & Moutsoglou, D. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2564333 · Cited by 1 · see citing works
Comparative efficacy of pharmacological interventions in ulcerative colitis: A Network Meta AnalysisPreprint
Khan, A. U., Ali, M., & Wahab, M. A. (2025) · Research Square · doi:10.21203/rs.3.rs-6255469/v1 · Cited by 1 · see citing works
Surgical Management of the Complex Crohn’s and Ulcerative Colitis Patient: When to Redo a Pouch
Lynn, P. B., & Schwartzberg, D. M. (2021) · Clinical gastroenterology · doi:10.1007/978-3-030-81780-0_13
Yang, T., Zhang, Y., Li, S., Sun, J., Wang, Y., & Deng, S. (2024) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm62325.2024.10821820
Identification and Verification of B4GALNT2 as an Epigenetic Marker in Ulcerative Colitis
Zhu, Y. Z., Zhou, Y. M., Jiang, H., Chen, Z., Lu, B., & Wu, J. (2025) · Digestion · doi:10.1159/000545944
Elhardalo, S. A., & Abuhzaima, E. A. (2025) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20252182
Lysosomal autophagy in the treatment of inflammatory bowel disease
Retnakumar, S. V. (2022) · theses.fr (ABES) · doi:10.70675/addbfec8zdb85z4eddz9c05zb59b895dc6c0
Huan, D. E. N. G., & Peng, Y. (2026) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.70418
“Although this design is methodologically sound [2], it complicates distinguishing the sustained benefit of continued guselkumab from disease relapse following treatment withdrawal.”
Kuppusamy, S., Gandhi, D. R., Epsiba, A., & SOWMYA, C. (2026) · ACS Omega · doi:10.1021/acsomega.5c13594
- Authors
- D’Amico, F., Parigi, T. L., Bonovas, S., Peyrin-Biroulet, L., & Danese, S.
- Affiliations
- Humanitas University (IT)
- Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France
- Corresponding author
- Danese, Silvio
- Venue
- Expert Opinion on Drug Safety
- Publisher
- Informa UK Limited
- Published
- 2020-06-08
- Volume
- 19
- Issue
- 7
- Pages
- 807-816
- ISSN
- 1474-0338 (ISSN-L)
- 1744-764X
- OpenAlex
- W3027483667
- Cited by
- 29
- References
- 47
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 3
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- ulcerative colitis, biologic therapy, long-term drug safety, inflammatory bowel disease, TNF-alpha inhibitors, safety profile, real-world evidence, 5-aminosalicylic acid, corticosteroids, immunosuppressants
- MeSH terms
- Anti-Inflammatory Agents, Biological Products, Colitis, Ulcerative, Humans, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review