The DOI matches its Crossref record.
The science of hyaluronic acid dermal fillers
Abstract
BACKGROUND: The use of injectable materials for soft-tissue augmentation has been increasing in the United States, reflecting the introduction of new hyaluronic acid (HA)-based dermal fillers. HA dermal fillers vary widely in their physical and chemical characteristics and many variables contribute to their overall performance. This article explains the basic science of HA and describes how the physical properties of HA dermal fillers may influence clinical outcomes. HYALURONIC ACID: The chemical composition of disaccharide HA monomers, and how they form polymer chains and are crosslinked into gels for dermal fillers are described. HYALURONIC ACID DERMAL FILLERS: Key concepts and properties relevant to the production and performance of HA dermal fillers, such as the degree of crosslinking, gel hardness, gel consistency, viscosity, extrusion force, HA concentration, and extent of hydration are explained. New formulations of HA dermal fillers that have recently been approved by the US Food and Drug Administration differ from currently available HA fillers and may provide enhanced ease of extrusion and persistence over previous fillers. CONCLUSION: Knowledge of the chemical and physical blueprint of HA dermal fillers may help physicians in choosing the appropriate HA dermal filler for facial enhancements. This, together with appropriate injector training and injection experience, should lead to results that ultimately will benefit patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Hydrogel microparticles for biomedical applications
Daly, A. C., Riley, L., Segura, T., & Burdick, J. A. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0148-6 · Cited by 1,249
High and low molecular weight hyaluronic acid differentially influence macrophage activation
Rayahin, J. E., Buhrman, J. S., Zhang, Y., Koh, T. J., & Gemeinhart, R. A. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00181 · Cited by 605
Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine
Mattheolabakis, G., Milane, L., Singh, A., & Amiji, M. M. (2015) · Journal of Drug Targeting · doi:10.3109/1061186x.2015.1052072 · Cited by 597
History and Applications of Hydrogels
Yahia, L. (2015) · Journal of Biomedical Sciencies · doi:10.4172/2254-609x.100013 · Cited by 339
Han, Y., Yang, J., Zhao, W., Wang, H., Sun, Y., Chen, Y., Luo, J., Deng, L., Xu, X., Cui, W., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.022 · Cited by 308
Metadata
- Authors
- Tezel, A., & Fredrickson, G. H.
- Venue
- Journal of Cosmetic and Laser Therapy
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 10
- Issue
- 1
- Pages
- 35-42
- ISSN
- 1476-4172 (ISSN-L)
- 1476-4180
- OpenAlex
- W2101842736
- Cited by
- 403
- References
- 0
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The science of hyaluronic acid dermal fillers. https://app.cochat.ai/papers/10.1080/14764170701774901
- The paper
- Tezel, A., & Fredrickson, G. H. (2008). The science of hyaluronic acid dermal fillers. Journal of Cosmetic and Laser Therapy. https://doi.org/10.1080/14764170701774901
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
