The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
Open accessAbstract
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive inflammatory response dominate the mechanism. In this study, bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel, we successfully developed injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment. Particularly, the lubricating microspheres (GelMA@DMA-MPC) were fabricated by dip coating a self-adhesive polymer (DMA-MPC, synthesized by free radical copolymerization) on superficial surface of photo-crosslinked methacrylate gelatin hydrogel microspheres (GelMA, prepared via microfluidic technology), and encapsulated with an anti-inflammatory drug of diclofenac sodium (DS) to achieve the dual-functional performance. The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the GelMA@DMA-MPC microspheres. In addition, the functionalized microspheres were intra-articularly injected into the rat knee joint with an OA model, and the biological tests including qRT-PCR, immunofluorescence staining assay, X-ray radiography and histological staining assay all revealed that the biocompatible microspheres provided significant therapeutic effect against the development of OA. In summary, the injectable hydrogel microspheres developed herein greatly improved lubrication and achieved sustained local drug release, therefore representing a facile and promising technique for the treatment of OA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Osteoarthritis cartilage histopathology: grading and staging
Pritzker, K. P. H., Gay, S., Jimenez, S. A., Ostergaard, K., Pelletier, J.-P., Revell, P. A., Salter, D., & van den Berg, W. B. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.07.014 · Cited by 2,340
Klein, J. (2013) · Friction · doi:10.1007/s40544-013-0001-7 · Cited by 567
Zhao, X., Liu, S., Yildirimer, L., Zhao, H., Ding, R., Wang, H., Cui, W., & Weitz, D. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504943 · Cited by 426
Self-citationThe science of hyaluronic acid dermal fillers
Tezel, A., & Fredrickson, G. H. (2008) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764170701774901 · Cited by 403
Advanced hydrogels for the repair of cartilage defects and regeneration
Wei, W., Ma, Y., Yao, X., Zhou, W., Wang, X., Li, C., Lin, J., He, Q., Leptihn, S., & Ouyang, H. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.030 · Cited by 357
Supramolecular synergy in the boundary lubrication of synovial joints
Seror, J., Zhu, L., Goldberg, R., Day, A. J., & Klein, J. (2015) · Nature Communications · doi:10.1038/ncomms7497 · Cited by 355
Tissue engineering of functional articular cartilage: the current status
Kock, L., van Donkelaar, C. C., & Ito, K. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1243-1 · Cited by 339
Research works printed but not linked: 6
- Zhang, 2011, The significance of the micropores at the stem–cement interface in total hip replacement, J. Biomater. Sci. Polym. Ed., 22, 845, 10.1163/092050610X540495 · doi:10.1163/092050610x540495
- Unlu, 2006, Comparison of intra-articular tenoxicam and oral tenoxicam for pain and physical functioning in osteoarthritis of the knee, Clin. Rheumatol., 25, 54, 10.1007/s10067-005-1136-3 · doi:10.1007/s10067-005-1136-3
- Sulistio, 2019, Intra-articular treatment of osteoarthritis with diclofenac-conjugated polymer reduces inflammation and pain, ACS Appl. Bio Mater., 2, 2822, 10.1021/acsabm.9b00232 · doi:10.1021/acsabm.9b00232
- Chen, 2016, Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy, Biomaterials, 81, 1, 10.1016/j.biomaterials.2015.12.006 · DOI
- Alexander, 2004, Idiopathic osteoarthritis: time to change paradigms, Skeletal Radiol., 33, 321, 10.1007/s00256-003-0727-9 · doi:10.1007/s00256-003-0727-9
- Tan, 2019, Mechanised lubricating silica nanoparticles for on-command cargo release on simulated surfaces of joint cavities, Chem. Commun., 55, 2593, 10.1039/C8CC10069A · doi:10.1039/c8cc10069a
Cited by
Xu, G., Jin, J., Fu, Z., Wang, G., Lei, X., Xu, J., & Wang, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02312-w · Cited by 269
Fabrication of AFM-Compatible Hydrogel Probe to Achieve Hydration Superlubrication in Salt Solutions
Wu, Z., Zhang, R., & Li, J. (2025) · Small · doi:10.1002/smll.202411253 · Cited by 13
Metadata
- Authors
- Han, Y., Yang, J., Zhao, W., Wang, H., Sun, Y., Chen, Y., Luo, J., Deng, L., Xu, X., Cui, W., & Zhang, H.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 6
- Issue
- 10
- Pages
- 3596-3607
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W3141007726
- Cited by
- 308
- References
- 36
- FWCI
- 31.54
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
- Funders
- National Natural Science Foundation of China (52022043, 81930051)
- Science and Technology Commission of Shanghai Municipality (18140901500, 18ZR1434200, 19440760400)
- Tsinghua University (10001020107)
- Shanghai Jiao Tong University (ZH2018ZDA04)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis. https://app.cochat.ai/papers/10.1016/j.bioactmat.2021.03.022
- The paper
- Han, Y., Yang, J., Zhao, W., Wang, H., Sun, Y., Chen, Y., Luo, J., Deng, L., Xu, X., Cui, W., & Zhang, H. (2021). Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2021.03.022
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
