The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
Hydrogel microparticles for biomedical applications
Open accessAbstract
Hydrogel microparticles (HMPs) are promising for biomedical applications, ranging from the therapeutic delivery of cells and drugs to the production of scaffolds for tissue repair and bioinks for 3D printing. Biologics (cells and drugs) can be encapsulated into HMPs of predefined shapes and sizes using a variety of fabrication techniques (batch emulsion, microfluidics, lithography, electrohydrodynamic spraying and mechanical fragmentation). HMPs can be formulated in suspensions to deliver therapeutics, as aggregates of particles (granular hydrogels) to form microporous scaffolds that promote cell infiltration or embedded within a bulk hydrogel to obtain multiscale behaviours. HMP suspensions and granular hydrogels can be injected for minimally invasive delivery of biologics, and they exhibit modular properties when comprised of mixtures of distinct HMP populations. In this Review, we discuss the techniques that are available for fabricating HMPs, as well as the multiscale behaviours of HMP systems and their functional properties, highlighting their advantages over traditional bulk hydrogels. Furthermore, we discuss applications of HMPs in the fields of cell delivery, drug delivery, scaffold design and biofabrication. Hydrogel microparticles are used for numerous biomedical applications, owing to their unique multiscale properties and design versatility. This Review discusses various hydrogel microparticle fabrication techniques and their diverse applications, ranging from cell and drug delivery to 3D printing.
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Cites
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Cited by
Design Challenges in Polymeric Scaffolds for Tissue Engineering
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Metadata
- Authors
- Daly, A. C., Riley, L., Segura, T., & Burdick, J. A.
- Venue
- Nature Reviews Materials
- Published
- 2019-11-07
- Volume
- 5
- Issue
- 1
- Pages
- 20-43
- ISSN
- 2058-8437 (ISSN-L)
- OpenAlex
- W2984883315
- Cited by
- 1,249
- References
- 218
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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