Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition
Abstract
OBJECTIVE: To evaluate the potential impact of adenomyosis on the pregnancy outcomes by retrospectively investigating adenomyosis-complicated pregnancy cases. METHODS: We performed a retrospective case-control study. Forty-nine singleton pregnancy cases complicated with adenomyosis were included in this study. The controls (n = 245) were singleton pregnant women without adenomyosis and were frequency matched to adenomyosis cases by age, parity, and the need for assisted reproductive technology for this conception. The incidence of obstetrical complications and delivery and neonatal outcomes were examined. RESULTS: Patients in the adenomyosis group were significantly more likely to have a second trimester miscarriage (12.2% versus 1.2%, odds ratio (OR): 11.2, 95% confidence interval (95% CI): 2.2-71.2), preeclampsia (18.3% versus 1.2%, OR: 21.0, 95% CI: 4.8-124.5), placental malposition (14.2% versus 3.2%, OR: 4.9, 95% CI: 1.4-16.3), and preterm delivery (24.4% versus 9.3%, OR: 3.1, 95% CI: 1.2-7.2), compared with the control group. CONCLUSION: Adenomyosis was associated not only with an increased incidence of preterm delivery, as previously reported, but also with an increased risk of second trimester miscarriage, preeclampsia, and placental malposition, which could lead to poor perinatal outcomes.
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Endometriosis, especially cystic ovarian and deep endometriosis, and adenomyosis are associated with abnormal placentation, insufficient physiologic changes in the spiral arteries, and an increased risk of preterm birth, small for gestational age babies, and preeclampsia.
“Endometriosis, especially cystic ovarian and deep endometriosis (130, 131), and adenomyosis (132, 133) are associated with abnormal placentation, insufficient physiologic changes in the spiral arteries, and an increased risk of preterm birth, small for gestational age (SGA) babies, and preeclampsia (131).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [133]
Cites
(2013) · doi:10.1097/01.aog.0000437382.03963.88 · Cited by 3,961 · see citing works
Preeclampsia: An excessive maternal inflammatory response to pregnancy
Redman, C. W. G., Sacks, G. P., & Sargent, I. L. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70239-5 · Cited by 1,838 · see citing works
Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
Duckitt, K., & Harrington, D. (2005) · BMJ · doi:10.1136/bmj.38380.674340.e0 · Cited by 1,784 · see citing works
The “Great Obstetrical Syndromes” are associated with disorders of deep placentation
Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.08.009 · Cited by 1,568 · see citing works
Bazot, M., Cortez, A., Daraï, É., Rouger, J., Chopier, J., Antoine, J.-M., & Uzan, S. (2001) · Human Reproduction · doi:10.1093/humrep/16.11.2427 · Cited by 501 · see citing works
Diffuse adenomyosis: comparison of endovaginal US and MR imaging with histopathologic correlation.
Reinhold, C., MCCARTHY, S. M., Bret, P. M., Mehio, A. R., Atri, M., Zakarian, R., Glaude, Y., Liang, L., & Seymour, R. J. (1996) · Radiology · doi:10.1148/radiology.199.1.8633139 · Cited by 417 · see citing works
Assisted Reproductive Technology and Pregnancy Outcome
Shevell, T., Malone, F. D., Vidaver, J., Porter, T. F., Luthy, D. A., Comstock, C. H., Hankins, G. D. V., Eddleman, K. A., Dolan, S. M., Dugoff, L., et al. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000183593.24583.7c · Cited by 351 · see citing works
Azziz, R. (1989) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(21)00148-0 · Cited by 316 · see citing works
Champaneria, R., Abedin, P., DANIELS, J. P., Balogun, M., & Khan, K. S. (2010) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349.2010.512061 · Cited by 240 · see citing works
MRI Characteristics of the Uterine Junctional Zone: From Normal to the Diagnosis of Adenomyosis
Novellas, S., Chassang, M., Delotte, J., Toullalan, O., Chevallier, A., Bouaziz, J., & Chevallier, P. (2011) · American Journal of Roentgenology · doi:10.2214/ajr.10.4877 · Cited by 219 · see citing works
Transvaginal ultrasound or MRI for diagnosis of adenomyosis
Dueholm, M., & Lundorf, E. (2007) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3282f1bf00 · Cited by 191 · see citing works
Adenomyosis: a systematic review of medical treatment
Pontis, A., D’Alterio, M. N., Pirarba, S., de Angelis, C., Tinelli, R., & Angioni, S. L. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1197200 · Cited by 190 · see citing works
Adenomyosis and risk of preterm delivery
Juang, C., Chou, P., Yen, M., Twu, N., Horng, H., & Hsu, W. (2007) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01186.x · Cited by 170 · see citing works
Inflammation: A link between endometriosis and preterm birth
Petraglia, F., Arcuri, F., de Ziegler, D., & Chapron, C. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.04.051 · Cited by 120 · see citing works
Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement
Mochimaru, A., Aoki, S., Oba, M. S., Kurasawa, K., Takahashi, T., & Hirahara, F. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12604 · Cited by 108 · see citing works
Vigano, P., Corti, L., & Berlanda, N. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.030 · Cited by 103 · cited 1× · see citing works
“However, only a limited number of studies have reported on pregnancies complicated by adenomyosis and the associations between adenomyosis and perinatal outcomes have not been thoroughly investigated [3].”
BackgroundIriyama, T., Wang, W., Parchim, N. F., Song, A., Blackwell, S. C., Sibai, B. M., Kellems, R. E., & Xia, Y. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05314 · Cited by 100 · see citing works
Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome
Conti, N., Cevenini, G., Vannuccini, S., Orlandini, C., Valensise, H. C. C., Gervasi, M. T., Ghezzi, F., Tommaso, M. D., Severi, F. M., & Petraglia, F. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.968843 · Cited by 90 · see citing works
Takemura, Y., Osuga, Y., Fujimoto, A., Oi, N., Tsutsumi, R., Koizumi, M., Yano, T., & Taketani, Y. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.706669 · Cited by 61 · see citing works
Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement
持丸, 綾. (2015) · Cited by 55 · see citing works
Valentin, L. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.06.001 · Cited by 52 · see citing works
Toshimitsu, M., Nagamatsu, T., Nagasaka, T., Iwasawa, Y., Komatsu, A., Yamashita, T., Osuga, Y., & Fujii, T. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.011 · Cited by 47 · see citing works
Adénomyose : quel bilan d’imagerie moderne ?
Taourel, P., Laffargue, G., & Déchaud, H. (2004) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2004.09.010 · Cited by 13 · see citing works
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Rethinking mechanisms, diagnosis and management of endometriosis
Chapron, C., Marcellin, L., Borghese, B., & Santulli, P. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0245-z · Cited by 1,084 · see citing works
Pathogenesis of endometriosis: The genetic/epigenetic theory
Koninckx, P. R., Ussia, A., Adamyan, L., Wattiez, A., Gomel, V., & Martin, D. C. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.013 · Cited by 427 · see citing works
Diagnosing adenomyosis: an integrated clinical and imaging approach
Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., Gordts, S., Guo, S., Just, P., Noël, J., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz049 · Cited by 439 · see citing works
Horton, J., Sterrenburg, M. D., Lane, S. I. R., Maheshwari, A., Li, T. C., & Cheong, Y. C. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz012 · Cited by 387 · see citing works
Recent advances in understanding and managing adenomyosis
Vannuccini, S., & Petraglia, F. (2019) · F1000Research · doi:10.12688/f1000research.17242.1 · Cited by 298 · see citing works
Progesterone Actions and Resistance in Gynecological Disorders
MacLean, J. A., & Hayashi, K. (2022) · Cells · doi:10.3390/cells11040647 · Cited by 195 · see citing works
Nirgianakis, K., Kalaitzopoulos, D. R., Schwartz, A. K., Spaanderman, M. E. A., Kramer, B. W. W., Mueller, M. D., & Mueller, M. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.09.023 · Cited by 162 · see citing works
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations
Inoue, S., Hirota, Y., Ueno, T., Fukui, Y., Yoshida, E., Hayashi, T., Kojima, S., Takeyama, R., Hashimoto, T., Kiyono, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13708-y · Cited by 139 · see citing works
Bruun, M. R., Arendt, L. H., Forman, A., & Ramlau‐Hansen, C. H. (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13364 · Cited by 80 · see citing works
Tan, J., Moriarty, S., Taşkın, Ö., Allaire, C., Williams, C., Yong, P. J., & Bedaiwy, M. A. (2018) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2017.12.020 · Cited by 72 · see citing works
Complications and outcomes of pregnant women with adenomyosis in Japan
Tamura, H., Kishi, H., Kitade, M., Asai‐Sato, M., Tanaka, A., Murakami, T., Minegishi, T., & Sugino, N. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12050 · Cited by 69 · see citing works
Influence of adenomyosis on pregnancy and perinatal outcomes in women with endometriosis
Scala, C., Maggiore, U. L. R., Racca, A., Barra, F., Vellone, V. G., Venturini, P. L., & Ferrero, S. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18989 · Cited by 64 · see citing works
Yamaguchi, A., Kyozuka, H., Fujimori, K., Hosoya, M., Yasumura, S., Yokoyama, T., Satô, A., Hashimoto, K., & The Japan Environment and Children's Study Group (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13498 · Cited by 60 · see citing works
Systematic review and meta‐analysis of adverse pregnancy outcomes after uterine adenomyosis
Razavi, M., Maleki‐Hajiagha, A., Sepidarkish, M., Rouholamin, S., Almasi‐Hashiani, A., & Rezaeinejad, M. (2019) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12799 · Cited by 60 · see citing works
Huang, Y., Zhao, X., Chen, Y., Wang, J., Zheng, W., & Cao, L. (2020) · BioMed Research International · doi:10.1155/2020/4381346 · Cited by 55 · see citing works
Shi, J., Xu, Q., Yu, S., & Zhang, T. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01040-1 · Cited by 50 · see citing works
The Investigation and Management of Adenomyosis in Women Who Wish to Improve or Preserve Fertility
Li, J.-J., Chung, J. P. W., Wang, S., Li, T. C., & Duan, H. (2018) · BioMed Research International · doi:10.1155/2018/6832685 · Cited by 50 · see citing works
Adenomyosis: Impact on Fertility and Obstetric Outcomes
Buggio, L., Dridi, D., & Barbàra, G. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00679-z · Cited by 45 · see citing works
Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up
Martire, F. G., Costantini, E., d’Abate, C., Schettini, G., Sorrenti, G., Centini, G., Zupi, E., & Lazzeri, L. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050298 · Cited by 42 · see citing works
Adenomyosis and infertility: the role of the junctional zone
Barbanti, C., Centini, G., Lazzeri, L., Habib, N., Labanca, L., Zupi, E., Afors, K., & Starace, A. C. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1878131 · Cited by 38 · see citing works
Busnelli, A., Simone, N. D., Somigliana, E., Greppi, D., Cirillo, F., Bulfoni, A., Inversetti, A., & Levi-Setti, P. E. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae024 · Cited by 43 · see citing works
Juárez‐Barber, E., Segura-Benítez, M., Carbajo‐García, M. C., Bas-Rivas, A., Faus, A., Vidal, C., Gilés, J., Labarta, E., Pellicer, A., Cervelló, I., et al. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.12.008 · Cited by 34 · see citing works
Obstetrical complications and outcome in patients with endometriosis
Borisova, A. V., Konnon, S. R., Tosto, V., Gerli, S., & Radzinsky, V. E. (2020) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2020.1793326 · Cited by 32 · see citing works
Shinohara, S., Okuda, Y., Hirata, S., & Suzuki, K. (2020) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.251.231 · Cited by 27 · see citing works
Harada, T., Taniguchi, F., & Harada, T. (2022) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12473 · Cited by 30 · see citing works
Rees, C. O., van Vliet, H., Siebers, A. G., Bulten, J., Huppelschoten, A. G., Westerhuis, M. E. M. H., Mischi, M., & Schoot, B. C. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.12.013 · Cited by 27 · see citing works
Mandelbaum, R. S., Melville, S. J. F., Violette, C. J., Guner, J. Z., Doody, K. A., Matsuzaki, S., Quinn, M. M., Ouzounian, J. G., Paulson, R. J., & Matsuo, K. (2023) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.14581 · Cited by 24 · see citing works
The importance of the junctional zone of the endometrium in human reproduction
Tanos, V., Lingwood, L., & Balami, S. (2020) · Human Fertility · doi:10.1080/14647273.2020.1720316 · Cited by 24 · see citing works
Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility
Juárez‐Barber, E., Francés‐Herrero, E., Corachán, A., Vidal, C., Gilés, J., Alamá, P., Faus, A., Pellicer, A., Cervelló, I., & Ferrero, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020219 · Cited by 22 · see citing works
Liang, T., Zhang, W., Pan, N., Han, B., Li, R., & Ma, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.865358 · Cited by 26 · see citing works
New paradigms in the conservative surgical and interventional management of adenomyosis
Alvi, F. A., Glaser, L. M., Chaudhari, A., Tsai, S., & Milad, M. P. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000371 · Cited by 21 · see citing works
Hashimoto, A., Iriyama, T., Sayama, S., 明日香, 岡., Kato, K., Fujii, T., Kubota, K., Ichinose, M., Sone, K., Kumasawa, K., et al. (2023) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2023.2226789 · Cited by 21 · see citing works
Iwasawa, T., Takahashi, T., Maeda, E., Ishiyama, K., Takahashi, S., Suganuma, R., Matsuo, K., Tachibana, M., Fukuhara, R., Shirasawa, H., et al. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00764-7 · Cited by 19 · see citing works
The Impact of Adenomyosis on Pregnancy and Pregnancy Outcomes: A Review
Wendel, M. P., & Magann, E. F. (2022) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000001042 · Cited by 18 · see citing works
Tellum, T., Naftalin, J., Chapron, C., Dueholm, M., Guo, S., Hirsch, M., Larby, E. R., Munro, M. G., Sarıdoğan, E., van der Spuy, Z. M., et al. (2022) · Human Reproduction · doi:10.1093/humrep/deac166 · Cited by 18 · see citing works
Extracellular vesicles contribute to EMT in adenomyosis by inducing macrophage polarization
Hu, Y., Yuan, M., Cheng, L., & Wang, G. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad015 · Cited by 19 · see citing works
Kim, Y., Kim, S. H., Kim, J., Sung, J., Choi, S., Oh, S., & Roh, C. (2019) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2019.07.004 · Cited by 18 · see citing works
Effects of adenomyosis on obstetric outcomes
Cozzolino, M., Basile, F., & Pontrelli, G. (2019) · Minerva Obstetrics and Gynecology · doi:10.23736/s0026-4784.18.04318-6 · Cited by 17 · see citing works
Adenomyosis: Disease, uterine aging process leading to symptoms, or both?
Πρωτόπαπας, Α., Grimbizis, G., Athanasiou, S., & Loutradis, D. (2020) · PubMed Central · Cited by 17 · see citing works
The Impact of Conservative Surgical Treatment of Adenomyosis on Fertility and Perinatal Outcomes
Moawad, G., Youssef, Y., Fruscalzo, A., Faysal, H., Mérida, M. G., Pirtea, P., Guani, B., Ayoubi, J. M., & Féki, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13092531 · Cited by 16 · see citing works
Zhang, X., Zhang, Y., Shi, R., Zhang, Y., Zhang, X.-L., Hu, X., Hu, X., & Hu, Y. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-021-06011-z · Cited by 16 · see citing works
The Impact of Adenomyosis on Pregnancy
Tsikouras, P. N., Kritsotaki, N., Nikolettos, K., Kotanidou, S., Oikonomou, E., Bothou, Α., Andreou, S., Nalmpanti, T., Chalkia, K., Spanakis, V., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12081925 · Cited by 15 · see citing works
Possible risks and benefits of adenomyomectomy on pregnancy outcomes: a retrospective analysis
Sayama, S., Iriyama, T., Hashimoto, A., Suzuki, K., Ariyoshi, Y., Yano, E., Toshimitsu, M., Ichinose, M., Seyama, T., Sone, K., et al. (2023) · AJOG Global Reports · doi:10.1016/j.xagr.2023.100265 · Cited by 14 · see citing works
Adenomyosis and obstetric complications: A retrospective case–control study
de Rozario, T., Jochum, F., Schwaab, T., Garbin, O., Roy, C., & Host, A. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.11.011 · Cited by 14 · see citing works
Adenomyosis-associated infertility: an update of the immunological perspective
Cao, Y., Yang, D., Cai, S., Yang, L., Yu, S., Geng, Q., Mo, M., Li, W., Wei, Y., Li, Y., et al. (2024) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2024.104703 · Cited by 16 · see citing works
Wu, Y., Yang, R., Lin, H., Lin, H., Cao, C., Jiao, X., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.902083 · Cited by 14 · see citing works
Transabdominal selective feticide in dichorionic twins: Ten years’ experience at a single center
Kim, M. S., Na, E. D., Kang, S., Shin, S. Y., Lim, B. B., Kim, H., & Moon, M. J. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13830 · Cited by 14 · see citing works
Kato, K., Iriyama, T., Hara, K., Suzuki, K., Hashimoto, A., Sayama, S., Ichinose, M., Toshimitsu, M., Seyama, T., Sone, K., et al. (2023) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15849 · Cited by 13 · see citing works
Adenomyosis and fertility‐sparing surgery: A literature appraisal
Pecorella, G., Nigdelis, M. P., Sparić, R., Morciano, A., & Tinelli, A. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.15389 · Cited by 13 · see citing works
Ranjan, Y. S., Ziauddeen, N., Stuart, B. L., Alwan, N. A., & Cheong, Y. C. (2023) · Reproduction and Fertility · doi:10.1530/raf-22-0070 · Cited by 13 · see citing works
Ge, L., Li, Y., Zhou, J., Zhao, X., Chen, X., Wang, W., Li, Z., Ge, P., & Cui, L. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-077025 · Cited by 12 · see citing works
Tellum, T., Qvigstad, E., Skovholt, E. K., & Lieng, M. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2019.02.002 · Cited by 12 · see citing works
Ono, Y., Ota, H., Takimoto, K., Tsuzuki, Y., Nakajima, A., Yoshino, O., Unno, N., Fujino, T., Fukushi, Y., & Wada, S. (2021) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2021.102114 · Cited by 12 · see citing works
Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway
Liang, N., Zhang, W., Wang, H.-J., Shi, W., Wang, L., & Ma, L. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s248095 · Cited by 12 · see citing works
Deep Infiltrating Endometriosis and Adenomyosis: Implications on Pregnancy and Outcome
Gruber, T. M., Ortlieb, L., Henrich, W., & Mechsner, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010157 · Cited by 11 · see citing works
Elsherbini, M., Koga, K., Hiraoka, T., Kumasawa, K., Maki, E., Satake, E., Taguchi, A., Makabe, T., Takeuchi, A., Izumi, G., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22413-8 · Cited by 11 · see citing works
Hu, Y., Yuan, M., Cheng, L., Xu, L., & Wang, G. (2024) · Molecular Human Reproduction · doi:10.1093/molehr/gaae010 · Cited by 11 · see citing works
Impact of adenomyosis on perinatal outcomes: a large cohort study (JSOG database)
Komatsu, H., Taniguchi, F., & Harada, T. (2023) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-023-05895-w · Cited by 11 · see citing works
Marshall, A., Kommoss, K. S., Ortmann, H., Kirchner, M., Jauckus, J., Sinn, H., Strowitzki, T., & Germeyer, A. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01083-9 · Cited by 10 · see citing works
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Bertucci, E., Sileo, F. G., Diamanti, M., Alboni, C., Facchinetti, F., & Marca, A. L. (2022) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14383 · Cited by 10 · see citing works
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Effectiveness of Laparoscopic Adenomyomectomy on Perinatal Outcomes
Ono, Y., Ota, H., Fukushi, Y., Tagaya, H., Okuda, Y., Yoshino, O., Yamada, H., Hirata, S., & Wada, S. (2023) · Gynecology and Minimally Invasive Therapy · doi:10.4103/gmit.gmit_45_22 · Cited by 9 · see citing works
Association between adenomyosis volume and adverse perinatal outcomes: multicenter cohort study
Ni, X., Su, X., Shi, Y., Ru, P., Liu, Y., Lei, S., Gu, Y., Liu, M., & Duan, T. (2024) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.29108 · Cited by 8 · see citing works
Arsalan, H. M., Mumtaz, H., & Laganà, A. S. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.01.004 · Cited by 8 · see citing works
Xu, X., Cai, B., Liu, Y., Liu, R., & Li, J. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11816 · Cited by 8 · see citing works
Trinchant, R., Cruz, M., & Requena, A. (2022) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14256 · Cited by 9 · see citing works
Gómez-Pereira, E., Burgos, J., Mendoza, R., Pérez-Ruiz, I., Olaso, F., Garcia, D. A., Malaina, I., & Matorras, R. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01054-2 · Cited by 8 · see citing works
Sun, T., Li, X., Shi, J., Wu, Y., Gu, Z., & Leng, J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.696374 · Cited by 8 · see citing works
Adenomyosis with uterine abscess formation treated by adenomyomectomy: A report of two cases
Hiratsuka, D., Ishizawa, C., Iida, R., Fukui, Y., Matsuo, M., Nishida, M., Ikemura, M., Harada, M., Wada‐Hiraike, O., Osuga, Y., et al. (2024) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.16185 · Cited by 7 · see citing works
Trinchant, R., Cruz, M., Requena, A., & García-Velasco, J. A. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.16082 · Cited by 9 · see citing works
Li, Y., Ge, L., Yang, X., Cui, L., & Chen, Z. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1248274 · Cited by 6 · see citing works
Ichinose, M., Iriyama, T., Hiraike, O., Sayama, S., Hashimoto, A., Suzuki, K., Matsuo, M., Toshimitsu, M., Seyama, T., Sone, K., et al. (2025) · Reproductive Sciences · doi:10.1007/s43032-024-01758-7 · Cited by 6 · see citing works
Pregnancy‐induced hemorrhagic degeneration of adenomyosis
Nakanishi, M., Iriyama, T., Sayama, S., Hanaoka, S., Toshimitsu, M., Seyama, T., Sone, K., Kumasawa, K., Nagamatsu, T., & Osuga, Y. (2022) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15195 · Cited by 6 · see citing works
Cardiometabolic profiles in women with adenomyosis
Ateş, S., Aydın, S., & Özcan, P. (2022) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2022.2099256 · Cited by 6 · see citing works
Macrophage polarization in adenomyosis: A review
Qiu, Y., Cao, J., Li, S., Liu, Y., Wan, G., & Gui, T. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13841 · Cited by 7 · see citing works
Wang, Y., Hu, Z., Jiang, P., Kong, W., Gong, C., Chen, Y., Xu, L., Yang, Y., & Hu, Z. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07136-z · Cited by 5 · see citing works
Kim, M. S., Jang, J. H., Park, S., Ahn, E. H., & Jung, S. H. (2021) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2020.1867969 · Cited by 5 · see citing works
Adenomyosis and Obstetrical Outcome: a Narrative Mini-Review of the Latest Evidence
Berlanda, N., Donati, A., Fedele, F., Lepri, M., & Vercellini, P. (2022) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-021-00316-1 · Cited by 5 · see citing works
Liu, L., Wang, T., Li, Y., Tian, H., Zhou, C., & Cai, W. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-08323-3 · Cited by 6 · see citing works
IL-18 produced by pregnant uterus promotes essential inflammatory responses and fetoplacental growth
Ino, H., Negishi, Y., Horii, Y., Koike, E., Flavell, R. A., Suzuki, S., & Morita, R. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116865 · Cited by 4 · see citing works
Xu, P., He, X., Zhang, Y., Wang, Y., Zou, G., Wang, J., & Zhang, X. (2024) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog5101014 · Cited by 4 · see citing works
[Stratified treatment and management of adenomyosis].
Zhang, X., & Xu, P. (2019) · PubMed Central · doi:10.3785/j.issn.1008-9292.2019.04.01 · Cited by 4 · see citing works
Sayama, S., Iriyama, T., Takeiri, Y., Hashimoto, A., Toshimitsu, M., Ichinose, M., Seyama, T., Sone, K., Kumasawa, K., Nagamatsu, T., et al. (2023) · Journal of Perinatal Medicine · doi:10.1515/jpm-2023-0263 · Cited by 4 · see citing works
Nariai, M., Wada‐Hiraike, O., Iriyama, T., Seyama, T., Kumasawa, K., Hirota, Y., & Osuga, Y. (2025) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2025.04.010 · Cited by 4 · see citing works
Tian, Z., Lai, J., Zhai, Q.-J., Li, Y., Wang, Y., Chang, X., Zhu, H.-L., & Cui, H. (2022) · Gynecology and Obstetrics Clinical Medicine · doi:10.1016/j.gocm.2022.07.001 · Cited by 4 · see citing works
Hiratsuka, D., Omura, E., Ishizawa, C., Iida, R., Fukui, Y., Hiraoka, T., Akaeda, S., Matsuo, M., Harada, M., Wada‐Hiraike, O., et al. (2023) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-023-05956-0 · Cited by 4 · see citing works
Agrawala, S., Patil, J., Campbell, S. B., & Woodard, T. L. (2021) · Fertility Research and Practice · doi:10.1186/s40738-021-00097-4 · Cited by 4 · see citing works
Etrusco, A., Agrifoglio, V., D’Amato, A., Nigris, A. D., Maggiore, U. L. R., Donna, M. C. D., Riemma, G., & Cozzolino, M. (2025) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2025.11.008 · Cited by 5 · see citing works
Zhang, Q., Chen, Q., Li, T., Jia, Z., Bu, X., Liu, Y., Wang, S., & Liu, Y. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051740 · Cited by 3 · see citing works
The Genetic-Epigenetic Pathophysiology of Endometriosis: A Surgeon’s View
Koninckx, P. R., Ussia, A., Adamyan, L. V., Keckstein, J., Wattiez, A., Gomel, V., & Martin, D. C. (2020) · Springer eBooks · doi:10.1007/978-3-030-52984-0_6 · Cited by 3 · see citing works
Коваль, А. А., Popov, А. А., Fedorov, А. А., Tyurina, S. S., Овчаренко, Д. В., & Habibullakh, T. (2021) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush20212104135 · Cited by 3 · see citing works
Robotic-assisted excision of diffuse adenomyosis
Youssef, Y., Alkatout, İ., Ayoubi, J. M., Féki, A., & Moawad, G. (2024) · Facts Views and Vision in ObGyn · doi:10.52054/fvvo.16.3.034 · Cited by 3 · see citing works
Ying, X., & Yu, H. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70272 · Cited by 3 · see citing works
Horii, Y., Ino, H., Sasaki, F., Ishibashi, M., Koike, E., Kawamoto, Y., Flavell, R. A., Ohashi, R., Suzuki, S., Negishi, Y., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-16546-9 · Cited by 2 · see citing works
Fox, C. E., Kaur, R., Vigneswaran, K., Small, R., Carter, J., O'Donoghue, K., Heazell, A., David, A. L., Simpson, N., Care, A., et al. (2025) · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · doi:10.1002/ijgo.70621 · Cited by 2 · see citing works
Benefits of Surgical Intervention in Women with Endometriosis-Related Infertility
Alexander, P., Alexey, K., Anton, F., Tyurina, S. S., Irina, F., & Tamana, K. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91820 · Cited by 2 · see citing works
Adenomioma cervical de tipo endometrioide
Aguedo, A. Y. A., & Álvarez, G. G. C. (2019) · Revista Española de Patología · doi:10.1016/j.patol.2019.01.003 · Cited by 2 · see citing works
Tellum, T., Naftalin, J., Hirsch, M., Sarıdoğan, E., & Jurkovic, D. (2021) · Facts Views and Vision in ObGyn · doi:10.52054/fvvo.13.3.034 · Cited by 2 · see citing works
Netreba, E. A., Yarmolinskaya, M. I., Malysheva, O. V., Shalina, M. A., Tkachenko, N. N., & Koloshkina, A. V. (2023) · Journal of obstetrics and women s diseases · doi:10.17816/jowd487470 · Cited by 1 · see citing works
Impact of adenomyosis on fertility and obstetric outcomes among women in tertiary care center
Hoque, L. F., Begum, F., Apsara, S., & Zinan, A. Z. (2025) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20250173 · Cited by 1 · see citing works
- Authors
- Hashimoto, A., Iriyama, T., Sayama, S., Nakayama, T., Komatsu, A., Miyauchi, A., Nishii, O., Nagamatsu, T., Osuga, Y., & Fujii, T.
- Affiliations
- The University of Tokyo (JP)
- Japanese Red Cross Medical Center (JP)
- Teikyo University Hospital, Mizonokuchi (JP)
- Corresponding author
- Iriyama, Takayuki
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2017-02-09
- Volume
- 31
- Issue
- 3
- Pages
- 364-369
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2582200713
- Cited by
- 141
- References
- 23
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 16 · 2023: 20 · 2022: 25 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 9 · 2017: 3
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (15H04979, 16H05469)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- adenomyosis, perinatal outcomes, second-trimester miscarriage, preeclampsia, preterm birth, pregnancy complications, singleton pregnancy
- MeSH terms
- Abortion, Spontaneous, Adult, Female, Humans, Japan, Placenta Previa, Pre-Eclampsia, Pregnancy, Pregnancy Trimester, Second, Retrospective Studies, Reproductive Techniques, Assisted, Premature Birth, Adenomyosis
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