Inflammation: A link between endometriosis and preterm birth
Open accessAbstract
Endometriosis is a chronic inflammatory disease affecting women's health. Pain and infertility are the major symptoms caused by a hormonal/immunological dysfunction, which causes an endometrial impairment. The same pathogenetic mechanisms are also associated with preterm birth: hormones, cytokines, neurohormones, and growth factors interact in modulating extracellular matrix and prostaglandin secretion, thus activating the inflammatory process in placental membranes and myometrium. An overlap of molecules and mechanisms may explain the evidence that preterm birth is a common outcome in pregnant patients with endometriosis.
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AM-associated disruption of the junctional zone and inner myometrium may lead to placental implantation disorders.
“AM-associated disruption of the junctional zone and the inner myometrium may lead to placental implantation disorders [29,30,31,32].”
From Women with Endometriosis—Who Is at Risk for Complications Associated with Pregnancy and Childbirth? A Retrospective Case–Control Study (2024) · cites this paper as [30]
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- Authors
- Petraglia, F., Arcuri, F., de Ziegler, D., & Chapron, C.
- Affiliations
- University of Siena (IT)
- Sorbonne Paris Cité (FR)
- Corresponding author
- Petraglia, Felice
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 98
- Issue
- 1
- Pages
- 36-40
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2054323092
- Cited by
- 120
- References
- 55
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 17 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 3 · 2012: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, preterm birth, inflammation, cytokines, neurohormones, growth factors, prostaglandins, extracellular matrix, placental membranes, myometrium, infertility, pregnancy outcomes
- MeSH terms
- Endometriosis, Female, Humans, Infant, Newborn, Inflammation, Pregnancy, Pregnancy Complications, Risk Factors, Uterine Diseases, Premature Birth
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