Adenomyosis and risk of preterm delivery
Abstract
OBJECTIVE: To evaluate the risk of preterm delivery in patients with adenomyosis. DESIGN: A 1:2 nested case-control study. SETTING: Tertiary-care institution. POPULATION: A base cohort population of 2138 pregnant women who attended routine prenatal check-up between July 1999 and June 2005. METHODS: From this base cohort population, gravid women with singleton pregnancy who delivered prior to the completion of 37 weeks of gestation were identified and formed the study group. Singleton gravid women who had term delivery and who matched with age, body mass index, smoking, and status of previous preterm delivery were recruited concurrently and served as control group. Preterm delivery cases were further divided into spontaneous preterm delivery and preterm premature rupture of membranes (PPROM) cases. MAIN OUTCOME MEASURES: Risk analysis of preterm delivery between gravid women with and without adenomyosis. RESULTS: One-hundred and four preterm delivery case subjects and 208 control subjects were assessed. Overall, gravid women with adenomyosis were associated with significantly increased risk of preterm delivery (adjusted odds ratio 1.96, 95% CI 1.23-4.47, P=0.022). For subgroup analysis, gravid women with adenomyosis had an adjusted 1.84-fold risk of spontaneous preterm delivery (95% CI 1.32-4.31, P=0.012) and an adjusted 1.98-fold risk of PPROM (95% CI 1.39-3.15, P=0.017). CONCLUSIONS: Gravid women with adenomyosis were associated with increased risk of both spontaneous preterm delivery and PPROM. A common pathophysiological pathway may exist in these two disorders. Further in-depth biochemical and molecular studies are necessary to explore this phenomenon.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AM-associated disruption of the junctional zone and inner myometrium may lead to placental implantation disorders.
“AM-associated disruption of the junctional zone and the inner myometrium may lead to placental implantation disorders [29,30,31,32].”
From Women with Endometriosis—Who Is at Risk for Complications Associated with Pregnancy and Childbirth? A Retrospective Case–Control Study (2024) · cites this paper as [29]
Cites
The contribution of low birth weight to infant mortality and childhood morbidity
McCormick, M. C. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501103120204 · Cited by 2,119 · see citing works
Berkowitz, G. S., & Papiernik, E. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036128 · Cited by 860 · see citing works
Premature Rupture of the Fetal Membranes
Parry, S. I., & Strauss, J. F. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803053381006 · Cited by 771 · see citing works
Slattery, M. M., & Morrison, J. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11476-0 · Cited by 675 · see citing works
Pathophysiology of adenomyosis
Ferenczy, A. S. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.4.312 · Cited by 512 · see citing works
Bazot, M., Cortez, A., Daraï, É., Rouger, J., Chopier, J., Antoine, J.-M., & Uzan, S. (2001) · Human Reproduction · doi:10.1093/humrep/16.11.2427 · Cited by 501 · see citing works
Norwitz, E. R., Robinson, J. N., & Challis, J. R. G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908263410906 · Cited by 443 · see citing works
Infection in the pathogenesis of preterm labor.
Romero, R. J., Mazor, M., Wu, Y., Sirtori, M., Enrique Oyarzún, E., Mitchell, M. D., & Hobbins, J. C. (1988) · PubMed · Cited by 427 · see citing works
Magnetic resonance imaging and transvaginal ultrasonography for the diagnosis of adenomyosis
Dueholm, M., Lundorf, E., Hansen, E. S., Sørensen, J. S., Ledertoug, S., & Olesen, F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01962-8 · Cited by 273 · see citing works
Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice
Fidel, P. L., Romero, R. J., Wolf, N. A., Cutright, J. L., Ramírez, M., Araneda, H., & Cotton, D. B. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70180-6 · Cited by 249 · see citing works
Markers of risk for preterm delivery
Lockwood, C. J., & Kuczynski, E. (1999) · Journal of Perinatal Medicine · doi:10.1515/jpm.1999.001 · Cited by 216 · see citing works
Parazzini, F., Vercellini, P., Panazza, S., Chatenoud, L., Oldani, S., & Crosignani, P. G. (1997) · Human Reproduction · doi:10.1093/humrep/12.6.1275 · Cited by 213 · see citing works
Monitoring Women at Risk for Preterm Labor
Dyson, D. C., Danbe, K., Bamber, J. A., Crites, Y., Field, D. R., Maier, J. A., Newman, L. A., Ray, D. A., WALTON, D. L., & Armstrong, M. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801013380103 · Cited by 211 · see citing works
Adenomyosis: symptoms, histology, and pregnancy terminations
Levgur, M. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(99)00659-6 · Cited by 209 · see citing works
Challis, J. R. G., Lye, S. J., Gibb, W., Whittle, W. L., Patel, F. A., & Alfaidy, N. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03804.x · Cited by 160 · see citing works
Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1α in endometriosis
Drake, T. S., O’Brien, W. F., Ramwell, P. W., & Metz, S. A. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90033-8 · Cited by 143 · see citing works
Besinger, R. E., Niebyl, J. R., Keyes, W. G., & Johnson, T. R. B. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90569-d · Cited by 137 · see citing works
Kaga, N., Katsuki, Y., Obata, M., & Shibutani, Y. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70460-x · Cited by 136 · see citing works
Adenomyosis: a neglected diagnosis.
To, O., & Rc, S. (1977) · PubMed · Cited by 100 · see citing works
Bieglmayer, C., Hofer, G., Kainz, C., Reinthaller, A., Kopp, B., & Janisch, H. (1995) · Gynecological Endocrinology · doi:10.3109/09513599509160464 · Cited by 92 · see citing works
Disruption of the endometrial-myometrial border during pregnancy as a risk factor for adenomyosis
Curtis, K. M., Hillis, S. D., Marchbanks, P. A., & Peterson, H. B. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.124285 · Cited by 91 · see citing works
Clinical and environmental predictors of preterm labor.
Heffner, L. J., SHERMAN, C., Speizer, F. E., & Weiss, S. T. (1993) · PubMed · Cited by 78 · see citing works
Deligeoroglou, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06235.x · Cited by 71 · see citing works
Collagen metabolism in premature rupture of amniotic membranes.
Vadillo‐Ortega, F., González-Ávila, G., Karchmer, S., Cruz, N. M., Ayala-Ruiz, A., & Lama, M. S. (1990) · PubMed · Cited by 70 · see citing works
Pierzyński, P., Lemancewicz, A., Reinheimer, T. M., Åkerlund, M., & LAUDAŃSKI, T. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.02.008 · Cited by 58 · see citing works
Ja, D., Pelletier, J.-P., Zafarullah, M., et al. (1995) · PubMed · Cited by 53 · see citing works
Sz, B., Marshall, L., & Cuenca (1985) · PubMed · Cited by 42 · see citing works
Risk Factors for Spontaneous Preterm Birth: A Northern Italian Multicenter Case-Control Study
Carlini, L., Somigliana, E., Rossi, G., et al. (2002) · Gynecologic and Obstetric Investigation · doi:10.1159/000058370 · Cited by 30 · see citing works
Studies on Prostaglandin Production Relating to the Mechanism of Dysmenorrhea in Endometriosis
Koike, H., Ikenoue, T., & Mori, N. (1994) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.70.1_43 · Cited by 15 · see citing works
Manual of outpatient gynecology
Tilton, P. (1986) · Medical Entomology and Zoology · Cited by 9 · see citing works
Tjugum, J., & Norström, A. (1985) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(85)90147-9 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rethinking mechanisms, diagnosis and management of endometriosis
Chapron, C., Marcellin, L., Borghese, B., & Santulli, P. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0245-z · Cited by 1,084 · see citing works
Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome
Stephansson, O., Kieler, H., Granath, F., & Falconer, H. (2009) · Human Reproduction · doi:10.1093/humrep/dep186 · Cited by 234 · see citing works
Endometriosis and obstetrics complications: A systematic review and meta-analysis
Zullo, F., Spagnolo, E., Saccone, G., Acunzo, M., Xodo, S., Ceccaroni, M., & Berghella, V. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.07.019 · Cited by 227 · see citing works
Khong, Y., & Brosens, I. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2010.10.012 · Cited by 153 · see citing works
Preterm birth, ovarian endometriomata, and assisted reproduction technologies
Fernando, S., Breheny, S., Jaques, A. M., Halliday, J. L., Baker, G., & Healy, D. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.01.096 · Cited by 150 · see citing works
Hashimoto, A., Iriyama, T., Sayama, S., Nakayama, T., Komatsu, A., Miyauchi, A., Nishii, O., Nagamatsu, T., Osuga, Y., & Fujii, T. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1285895 · Cited by 141 · see citing works
Brosens, I., Pijnenborg, R., & Benagiano, G. (2013) · Placenta · doi:10.1016/j.placenta.2012.11.017 · Cited by 135 · see citing works
Risks of adverse pregnancy outcome in endometriosis
Brosens, I., Brosens, J. J., Fusi, L., Al-Sabbagh, M., Kuroda, K., & Benagiano, G. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.02.024 · Cited by 132 · see citing works
Inflammation: A link between endometriosis and preterm birth
Petraglia, F., Arcuri, F., de Ziegler, D., & Chapron, C. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.04.051 · Cited by 120 · see citing works
Dueholm, M. (2017) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.13158 · Cited by 113 · see citing works
Vigano, P., Corti, L., & Berlanda, N. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.030 · Cited by 103 · see citing works
Gruber, T. M., Ortlieb, L., Henrich, W., & Mechsner, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020414 · Cited by 9 · see citing works
“AM-associated disruption of the junctional zone and the inner myometrium may lead to placental implantation disorders [29–32].”
Background
- Authors
- Juang, C., Chou, P., Yen, M., Twu, N., Horng, H., & Hsu, W.
- Affiliations
- Taipei Veterans General Hospital (TW)
- National Yang Ming University (TW)
- Corresponding author
- Juang, C‐M
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 2007-01-09
- Volume
- 114
- Issue
- 2
- Pages
- 165-169
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2088260572
- Cited by
- 170
- References
- 31
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 4 · 2023: 14 · 2022: 12 · 2021: 15 · 2020: 14 · 2019: 15 · 2018: 11 · 2017: 15 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 7
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- adenomyosis, preterm birth, preterm premature rupture of membranes, spontaneous preterm labor, pregnancy outcomes, singleton pregnancy, risk factors
- MeSH terms
- Endometriosis, Female, Humans, Myometrium, Pregnancy, Risk Factors, Uterine Neoplasms, Case-Control Studies, Premature Birth
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
