Cited by 198Redox biology and oxidative stressNitric Oxide and Endothelin EffectsFree Radicals and Antioxidants

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The carbonate radical and related oxidants derived from bicarbonate buffer

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Medinas, Danilo B., Cerchiaro, Giselle, Trindade, Daniel F., Augusto, Ohara·2007·IUBMB Life

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Abstract

The unequivocal demonstration that the carbonate radical (CO3 •‐) is produced from the reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate‐carbon dioxide pair. Here, we review the biochemical properties of both the carbonate radical and peroxymonocarbonate (HCO4 ‐), and discuss the evidence of their formation under physiological conditions. Overall, the review emphasizes the recognition of the biological relevance of oxidants derived from the main physiological buffer as a crucial step into the understanding and control of numerous pathological states. IUBMB Life, 59: 1 ‐ 8, 2007 IUBMB Life, 59: 255‐262, 2007

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Authors: Medinas, D. B., Cerchiaro, G., Trindade, D. F., & Augusto, O.
Affiliations: Universidade de São Paulo (BR)
ORCID: Medinas, Danilo B.
Cerchiaro, Giselle
Venue: IUBMB Life
Publisher: Wiley
Published: 2007-01
Volume: 59
Issue: 4-5
Pages: 255-262
ISSN: 1521-6543 (ISSN-L)
1521-6551
DOI: 10.1080/15216540701230511
OpenAlex: W1983606357
Cited by: 198
References: 56
Citations by year: 2026: 5 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 21 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 8 · 2012: 13
FWCI: 0.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 367 d)
Locations: IUBMB Life (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: carbonate radical, peroxymonocarbonate, bicarbonate buffer, carbon dioxide, peroxynitrite, oxidizing agents, reactive oxygen species, physiological buffer, oxidative stress
MeSH terms: Superoxide Dismutase-1, Bicarbonates, Buffers, Carbonates, Free Radicals, Superoxide Dismutase, Xanthine Oxidase, Molecular Structure, Oxidants, Peroxynitrous Acid

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The carbonate radical and related oxidants derived from bicarbonate buffer

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