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The carbonate radical and related oxidants derived from bicarbonate buffer
Open accessAbstract
The unequivocal demonstration that the carbonate radical (CO3 •‐) is produced from the reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate‐carbon dioxide pair. Here, we review the biochemical properties of both the carbonate radical and peroxymonocarbonate (HCO4 ‐), and discuss the evidence of their formation under physiological conditions. Overall, the review emphasizes the recognition of the biological relevance of oxidants derived from the main physiological buffer as a crucial step into the understanding and control of numerous pathological states. IUBMB Life, 59: 1 ‐ 8, 2007 IUBMB Life, 59: 255‐262, 2007
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“A membrane metabolon including arginine succinate lyase, argininosuccinate synthetase, hsp90, and eNOS associates in the caveolae and is necessary for regular eNOS function (270, 294, 634).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [634]
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“Further studies showed that l-arginine import via the CAT1 transporter is critical for eNOS activity (167, 634).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [634]
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Metadata
- Authors
- Medinas, D. B., Cerchiaro, G., Trindade, D. F., & Augusto, O.
- Affiliations
- Universidade de São Paulo (BR)
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 59
- Issue
- 4-5
- Pages
- 255-262
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W1983606357
- Cited by
- 198
- References
- 56
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 21 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 8 · 2012: 13
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- carbonate radical, peroxymonocarbonate, bicarbonate buffer, carbon dioxide, peroxynitrite, oxidizing agents, reactive oxygen species, physiological buffer, oxidative stress
- MeSH terms
- Superoxide Dismutase-1, Bicarbonates, Buffers, Carbonates, Free Radicals, Superoxide Dismutase, Xanthine Oxidase, Molecular Structure, Oxidants, Peroxynitrous Acid
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