The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The carbonate radical and related oxidants derived from bicarbonate buffer
Open accessAbstract
The unequivocal demonstration that the carbonate radical (CO3 •‐) is produced from the reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate‐carbon dioxide pair. Here, we review the biochemical properties of both the carbonate radical and peroxymonocarbonate (HCO4 ‐), and discuss the evidence of their formation under physiological conditions. Overall, the review emphasizes the recognition of the biological relevance of oxidants derived from the main physiological buffer as a crucial step into the understanding and control of numerous pathological states. IUBMB Life, 59: 1 ‐ 8, 2007 IUBMB Life, 59: 255‐262, 2007
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A membrane metabolon including arginine succinate lyase, argininosuccinate synthetase, hsp90, and eNOS associates in the caveolae and is necessary for regular eNOS function (270, 294, 634).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [634]
In the citing paper
“Further studies showed that l-arginine import via the CAT1 transporter is critical for eNOS activity (167, 634).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [634]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Nitric oxide, oxidants, and protein tyrosine nitration
Radí, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307446101 · Cited by 1,477
Structure and function of xanthine oxidoreductase: where are we now?
Harrison, R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00956-5 · Cited by 807
COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS
Valentine, J. S., Doucette, P. A., & Potter, S. Z. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161647 · Cited by 790
Hodgson, E. K., & Fridovich, I. (1975) · Biochemistry · doi:10.1021/bi00695a010 · Cited by 781
Redox signaling and the MAP kinase pathways
Torres, M., & Forman, H. J. (2003) · BioFactors · doi:10.1002/biof.5520170128 · Cited by 580
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology
Augusto, O., Bonini, M. G., Amanso, A. M., Linares, E., Santos, C. C. X., & De Menezes, S. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00786-4 · Cited by 555
Self-citationRapid reaction between peroxonitrite ion and carbon dioxide: Implications for biological activity
Lymar, S. V., & Hurst, J. K. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00139a027 · Cited by 515
Richardson, D. E., Yao, H., Frank, K., & Bennett, D. A. (2000) · Journal of the American Chemical Society · doi:10.1021/ja9927467 · Cited by 503
Research works printed but not linked: 1
- Liochev, S. I., and Fridovich, I. (2004) CO 2 , not HCO 3 7 , facilitates oxidations by Cu,Zn superoxide dismutase plus H 2 O 2 . Proc. Natl. Acad. Sci. USA 101, 743 -744.
Cited by
Sorted by citations
Reconciling the chemistry and biology of reactive oxygen species
Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504
Mitochondria and reactive oxygen species
Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F., & Vercesi, A. E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.004 · Cited by 1,162
DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
Cadet, J., & Wagner, J. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012559 · Cited by 903
Direct human health risks of increased atmospheric carbon dioxide
Jacobson, T., Kler, J. S., Hernke, M. T., Braun, R., Meyer, K. C., & Funk, W. E. (2019) · Nature Sustainability · doi:10.1038/s41893-019-0323-1 · Cited by 620
Superoxide dismutases—A review of the metal-associated mechanistic variations
Abreu, I. A., & Cabelli, D. E. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.11.005 · Cited by 563
Metadata
- Authors
- Medinas, D. B., Cerchiaro, G., Trindade, D. F., & Augusto, O.
- Affiliations
- Universidade de São Paulo (BR)
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 59
- Issue
- 4-5
- Pages
- 255-262
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W1983606357
- Cited by
- 198
- References
- 56
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 21 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 8 · 2012: 13
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- carbonate radical, peroxymonocarbonate, bicarbonate buffer, carbon dioxide, peroxynitrite, oxidizing agents, reactive oxygen species, physiological buffer, oxidative stress
- MeSH terms
- Superoxide Dismutase-1, Bicarbonates, Buffers, Carbonates, Free Radicals, Superoxide Dismutase, Xanthine Oxidase, Molecular Structure, Oxidants, Peroxynitrous Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
