Neural Organoids and the Precautionary Principle
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Human neural organoid research is advancing rapidly. As Greely (2021) notes in the target article, this progress presents an “onrushing ethical dilemma.” We can’t rule out the possibility that suff...
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Given high moral stakes, some stakeholders may demand only low degrees of confidence in a measure and/or prioritization of sensitivity over specificity, often defended with reference to the precautionary principle.
“Given the high moral stakes, some stakeholders (e.g., animal rights advocates, AI developers, policy advocates, laypeople) may demand only low degrees of con fi dence in a measure and/or a prioritization of sensitivity over speci fi city, an approach that is often defended with reference to the ' precautionary principle ' [88,94,95].”
From Tests for consciousness in humans and beyond (2024) · cites this paper as [95]
Cites
Neural correlates of consciousness: progress and problems
Koch, C., Massimini, M., Boly, M., & Tononi, G. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.22 · Cited by 1,600 · see citing works
Conscious Processing and the Global Neuronal Workspace Hypothesis
Mashour, G. A., Roelfsema, P., Changeux, J.-P., & Dehaene, S. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.026 · Cited by 1,164 · see citing works
Consciousness without a cerebral cortex: A challenge for neuroscience and medicine
Merker, B. (2007) · Behavioral and Brain Sciences · doi:10.1017/s0140525x07000891 · Cited by 868 · see citing works
Defining and assessing animal pain
Sneddon, L. U., Elwood, R. W., Adamo, S. A., & Leach, M. C. (2014) · Animal Behaviour · doi:10.1016/j.anbehav.2014.09.007 · Cited by 508 · see citing works
Animal sentience and the precautionary principle
Birch, J. (2017) · Animal Sentience · doi:10.51291/2377-7478.1200 · Cited by 374 · see citing works
Self-citationThe search for invertebrate consciousness
Birch, J. (2022) · Noûs · doi:10.1111/nous.12351 · Cited by 254 · see citing works
Self-citationCoupling the State and Contents of Consciousness
Aru, J., Suzuki, M., Rutiku, R., Larkum, M. E., & Bachmann, T. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00043 · Cited by 164 · see citing works
Moral Limits of Brain Organoid Research
Koplin, J. J., & Savulescu, J. (2019) · The Journal of Law Medicine & Ethics · doi:10.1177/1073110519897789 · Cited by 156 · see citing works
Human Brain Surrogates Research: The Onrushing Ethical Dilemma
Greely, H. T. (2020) · The American Journal of Bioethics · doi:10.1080/15265161.2020.1845853 · Cited by 115 · see citing works
Derbyshire, S. W. G., & Bockmann, J. C. (2020) · Journal of Medical Ethics · doi:10.1136/medethics-2019-105701 · Cited by 98 · see citing works
Won’t Somebody Please Think of the Mammoths? De-extinction and Animal Welfare
Browning, H. (2018) · Journal of Agricultural and Environmental Ethics · doi:10.1007/s10806-018-9755-2 · Cited by 44 · see citing works
Self-citationBrowning, H. (2017) · Animal Sentience · doi:10.51291/2377-7478.1246 · Cited by 13 · see citing works
Self-citation
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Organoids: a systematic review of ethical issues
de Jongh, D., Massey, E. K., Berishvili, E., Fonseca, L. M., Lebreton, F., Bellofatto, K., Bignard, J., Seißler, J., Buerck, L. W.-V., Honarpisheh, M. M., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02950-9 · Cited by 208 · see citing works
Tests for consciousness in humans and beyond
Bayne, T., Seth, A. K., Massimini, M., Shepherd, J., Cleeremans, A., Fleming, S. M., Malach, R., Mattingley, J. B., Menon, D. K., Owen, A. M., et al. (2024) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2024.01.010 · Cited by 163 · see citing works
“…stakeholders(e.g.,animalrightsadvocates,AI developers,policyadvocates, lay-people) may demand only low degrees of con fi dence in a measure and/or a prioritization of sensitivity over speci fi city, an approach that is often defended with reference to the ‘ precautionary principle ’ [88,94,95].”
BackgroundThe Edge of Sentience: Risk and Precaution in Humans, Other Animals, and AI
Birch, J. (2024) · doi:10.1093/9780191966729.001.0001 · Cited by 236 · see citing works
Self-citationHuman Brain Organoids and Consciousness
Niikawa, T., Hayashi, Y., Shepherd, J., & Sawai, T. (2022) · Neuroethics · doi:10.1007/s12152-022-09483-1 · Cited by 79 · see citing works
Consciousness in a Rotor? Science and Ethics of Potentially Conscious Human Cerebral Organoids
Zilio, F., & Lavazza, A. (2023) · AJOB Neuroscience · doi:10.1080/21507740.2023.2173329 · Cited by 52 · see citing works
The sentience shift in animal research
Browning, H., & Veit, W. (2022) · The New Bioethics · doi:10.1080/20502877.2022.2077681 · Cited by 36 · see citing works
Self-citationDiner, S. (2023) · Neuroethics · doi:10.1007/s12152-023-09533-2 · Cited by 38 · see citing works
On the Legal Status of Human Cerebral Organoids: Lessons from Animal Law.
Jowitt, J. (2023) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s0963180122000858 · Cited by 7 · see citing works
‘Consciousnessoids’: clues and insights from human cerebral organoids for the study of consciousness
Lavazza, A. (2021) · Neuroscience of Consciousness · doi:10.1093/nc/niab029 · Cited by 30 · see citing works
Human cerebral organoids: the ethical stance of scientists
Lavazza, A., & Chinaia, A. A. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03291-x · Cited by 29 · see citing works
The Ethics of Human Brain Organoid Transplantation in Animals
Kataoka, M., Gyngell, C., Savulescu, J., & Sawai, T. (2023) · Neuroethics · doi:10.1007/s12152-023-09532-3 · Cited by 26 · see citing works
Kataoka, M., Niikawa, T., Nagaishi, N., Lee, T.-L., Erler, A., Savulescu, J., & Sawai, T. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151470 · Cited by 29 · see citing works
The Many Moral Matters of Organoid Models: A systematic review of reasons
Barnhart, A. J., & Dierickx, K. (2022) · Medicine Health Care and Philosophy · doi:10.1007/s11019-022-10082-3 · Cited by 22 · see citing works
Lavazza, A., & Reichlin, M. (2023) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s096318012300021x · Cited by 22 · see citing works
The Case Against Organoid Consciousness
Croxford, J., & Bayne, T. (2024) · Neuroethics · doi:10.1007/s12152-024-09548-3 · Cited by 23 · see citing works
How to deal with risks of AI suffering
Dung, L. (2025) · Inquiry · doi:10.1080/0020174x.2023.2238287 · Cited by 21 · see citing works
Kataoka, M., Gyngell, C., Savulescu, J., & Sawai, T. (2024) · Science and Engineering Ethics · doi:10.1007/s11948-024-00471-7 · Cited by 20 · see citing works
Human Brain Organoid Research and Applications: Where and How to Meet Legal Challenges?
Kataoka, M., Lee, T.-L., & Sawai, T. (2024) · Journal of Bioethical Inquiry · doi:10.1007/s11673-024-10349-9 · Cited by 16 · see citing works
Human Brain Organoids and Consciousness: Moral Claims and Epistemic Uncertainty
Goddard, E., Tomaskovic‐Crook, E., Crook, J. M., & Dodds, S. (2023) · Organoids · doi:10.3390/organoids2010004 · Cited by 16 · see citing works
The ethical landscape of human brain organoids and a mindful innovation framework
Shlobin, N. A., Savulescu, J., & Baum, M. L. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00211-3 · Cited by 15 · see citing works
Moral considerability of brain organoids from the perspective of computational architecture
Boyd, J. L. (2024) · Oxford Open Neuroscience · doi:10.1093/oons/kvae004 · Cited by 11 · see citing works
Stoeklé, H., Ivasilevitch, A., Marignac, G., & Hervé, C. (2021) · Cell Adhesion & Migration · doi:10.1080/19336918.2021.1996749 · Cited by 11 · see citing works
Charting bioethical frontiers: China’s human organoid guidelines in a global context
Zhou, L., Lei, Y., & Han, X. (2025) · Military Medical Research · doi:10.1186/s40779-025-00651-x · Cited by 9 · see citing works
Warwick, C., Pilny, A. A., Steedman, C., Howell, T. J., Silvestre, A. M., Cadenas, V., & Grant, R. (2023) · Animals · doi:10.3390/ani13020214 · Cited by 9 · see citing works
What Is, or Should Be, the Legal Status of Brain Organoids?
Taupitz, J. (2022) · Advances in neuroethics · doi:10.1007/978-3-030-97641-5_5 · Cited by 7 · see citing works
The welfare of brain organoids
Browning, H., & Veit, W. (2023) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17523.1 · Cited by 8 · see citing works
Self-citationTwo roads diverged: Pathways toward harnessing intelligence in neural cell cultures
Kagan, B. J. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100156 · Cited by 7 · see citing works
Human Cerebral Organoids: Evolving Entities and Their Moral Status
Lavazza, A. (2022) · Advances in neuroethics · doi:10.1007/978-3-030-97641-5_4 · Cited by 7 · see citing works
Why brain organoids are not conscious yet
Kosik, K. S. (2024) · Patterns · doi:10.1016/j.patter.2024.101011 · Cited by 7 · see citing works
Extrapolating Other Consciousnesses: The Prospects and Limits of Analogical Abduction
Negro, N., & Mudrik, L. (2025) · Philosophy of Science · doi:10.1017/psa.2025.10104 · Cited by 6 · see citing works
When is a brain organoid a sentience candidate?
Birch, J. (2023) · Molecular Psychology: Brain, Behavior, and Society · doi:10.12688/molpsychol.17524.1 · Cited by 12 · see citing works
Self-citationWhen is a brain organoid a sentience candidate?
Birch, J. (2024) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17524.2 · Cited by 5 · see citing works
Self-citationFacing the possibility of consciousness in human brain organoids
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Boyd, J. L., Jensen, E. A., Jensen, A. M., & Lipshitz, N. (2026) · Scientific Reports · doi:10.1038/s41598-026-43243-y · Cited by 4 · see citing works
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Ishida, S., Kagan, B. J., Kataoka, M., Koplin, J., Mann, S. P., Lewis, J., Browning, H., Erler, A., Feroz, F., Fukushi, T., et al. (2026) · Asian Bioethics Review · doi:10.1007/s41649-025-00398-6 · Cited by 2 · see citing works
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Zilio, F. (2023) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17555.1 · Cited by 2 · see citing works
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Veit, W., & Browning, H. (2021) · AJOB Neuroscience · doi:10.1080/21507740.2021.2001079 · Cited by 2 · see citing works
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Birch, J. (2024) · doi:10.1093/9780191966729.003.0001 · Cited by 1 · see citing works
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Jowitt, J. (2023) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17531.1 · Cited by 1 · see citing works
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Boyd, J. L. (2023) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17558.1 · Cited by 1 · see citing works
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Veit, W. (2021) · PhilSci-Archive (University of Pittsburgh) · doi:10.13140/rg.2.2.18055.83367
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Lavazza, A., & Chinaia, A. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19045-2.00014-3
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Gaillard, M. (2024) · Revue de métaphysique et de morale · doi:10.3917/rmm.241.0029
Birch, J. (2024) · doi:10.1093/9780191966729.003.0011
Self-citationBirch, J. (2024) · doi:10.1093/9780191966729.003.0009
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Additional file 1 of Human cerebral organoids: the ethical stance of scientists
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Additional file 1 of Organoids: a systematic review of ethical issues
de Jongh, D., Massey, E. K., & Bunnik, E. M. (2022) · Figshare · doi:10.6084/m9.figshare.20364906
Additional file 2 of Organoids: a systematic review of ethical issues
de Jongh, D., Massey, E. K., & Bunnik, E. M. (2022) · Figshare · doi:10.6084/m9.figshare.20364909
Extrapolating Consciousness in Isolated Hemispheres. Hemispherotomy as a New Challenge
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- Authors
- Birch, J., & Browning, H.
- Affiliations
- London School of Economics and Political Science (GB)
- Corresponding author
- Birch, Jonathan
- Venue
- The American Journal of Bioethics
- Publisher
- Informa UK Limited
- Published
- 2020-12-29
- Volume
- 21
- Issue
- 1
- Pages
- 56-58
- ISSN
- 1526-5161 (ISSN-L)
- 1536-0075
- OpenAlex
- W3114104700
- Cited by
- 88
- References
- 12
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 41 · 2023: 16 · 2022: 9 · 2021: 6
- Type
- journal article
- Language
- en
- Open access
- green
- philarchive.org
- Locations
- The American Journal of Bioethics (publishedVersion)
- PubMed (publishedVersion)
- PhilSci-Archive (University of Pittsburgh) (acceptedVersion)
- London School of Economics and Political Science Research Online (London School of Economics and Political Science) (acceptedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- PhilPapers (PhilPapers Foundation) (submittedVersion)
- London School of Economics and Political Science Theses Online (London School of Economics and Political Science) (submittedVersion)
- Funders
- European Research Council
- European Union’s Horizon 2020 research and innovation programme (851145)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
- Health Sciences › Medicine › Physiology › Biomedical Ethics and Regulation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
- Keywords
- brain organoids, precautionary principle, research ethics, ethical dilemmas
- MeSH terms
- Brain, Environmental Health, Humans, Organoids, Public Health
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