The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Human Germline Genome Editing: On the Nature of Our Reasons to Genome Edit
Abstract
bioethicists have tended to distinguish between two different ways in which reproductive technologies may have implications for the welfare of future persons. Some interventions harm or benefit particular individuals: they are "person affecting." Other interventions determine which individual, of a number of possible individuals, comes into existence: they are "identity affecting" and raise the famous "non-identity problem." For the past several decades, bioethical debate has, for the most part, proceeded on the assumption that direct genetic modification of human embryos would be person affecting. In this paper, I argue that that genome editing is highly unlikely to be person affecting for the foreseeable future and, as a result, will neither benefit nor harm edited individuals.
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“It is a contested issue whether an event or action (e.g., an i-HGE experiment) that causes a person to exist can harm or benefit this person or whether such an event is neutral for this specific person (Sparrow 2021).”
From Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic (2023) · cites this paper as Sparrow 2021
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Cites
Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells
Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S., & Saitou, M. (2011) · Cell · doi:10.1016/j.cell.2011.06.052 · Cited by 1,379
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y., et al. (2015) · Protein & Cell · doi:10.1007/s13238-015-0153-5 · Cited by 1,135
Derivation of Oocytes from Mouse Embryonic Stem Cells
Hübner, K., Fuhrmann, G., Christenson, L. K., Kehler, J., Reinbold, R., De La Fuente, R., Wood, J., Strauss, J. F., Boiani, M., & Schöler, H. R. (2003) · Science · doi:10.1126/science.1083452 · Cited by 1,075
In the Name of Eugenics: Genetics and the Uses of Human Heredity
Rosenberg, C. E., & Kevles, D. J. (1986) · The Journal of American History · doi:10.2307/1903699 · Cited by 1,070
Correction of a pathogenic gene mutation in human embryos
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Procreative Beneficence: Why We Should Select the Best Children
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SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate
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Research works printed but not linked: 10
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Cited by
Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic
Ranisch, R., Trettenbach, K., & Arnason, G. (2023) · Medicine, Health Care and Philosophy · doi:10.1007/s11019-022-10115-x · Cited by 19
Metadata
- Authors
- Sparrow, R.
- Venue
- The American Journal of Bioethics
- Publisher
- Informa UK Limited
- Published
- 2021-04-19
- Volume
- 22
- Issue
- 9
- Pages
- 4-15
- ISSN
- 1526-5161
- 1536-0075
- Cited by
- 40
- References
- 80
- Language
- en
- Funders
- Australian Research Council’s Discovery Projects funding scheme (9)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
