Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells
Open accessAbstract
Tumors are comprised of malignant cancer cells and stromal cells which constitute the tumor microenvironment (TME). Previous studies have shown that cancer associated fibroblast (CAF) in TME is an important promoter of tumor initiation and progression. However, the underlying molecular mechanisms by which CAFs influence the growth of colorectal cancer cells (CRCs) have not been clearly elucidated. In this study, by using a non-contact co-culture system between human colorectal fibroblasts (CCD-18-co) and CRCs (LoVo, SW480, and SW620), we found that fibroblasts existing in tumor microenvironment positively influenced the metabolism of colorectal cancer cells, through its autophagy and oxidative stress pathway which were initially induced by neighboring tumor cells. Therefore, our data provided a novel possibility to develop fibroblasts as a potential target to treat CRC.
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CAFs positively influence the proliferation and metabolism of cancer cells through oxidative stress, which induces the autophagy pathway.
“Moreover, CAFs positively influence the proliferation and metabolism of cancer cells through oxidative stress, which induces the autophagy pathway [69].”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [69]
The Abstract and Discussion report that colorectal cancer cells induce oxidative stress and autophagy in fibroblasts, which then support colorectal cancer-cell metabolism and proliferation. The claim omits the study’s colorectal-cancer setting and could imply that CAFs, rather than the cancer cells, initiate the oxidative stress. (LLM, conf=0.86)
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- Authors
- Zhou, W., Xu, G., Wang, Y., Xu, Z., Liu, X., Xu, X., Ren, G., & Tian, K.
- Affiliations
- Shandong University (CN)
- Department of Gastroenterology, 456 Hospital of PLA, Jinan, Shandong, China
- First Affiliated Hospital of Anhui Medical University (CN)
- Corresponding author
- Tian, Keli
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2016-11-28
- Volume
- 16
- Issue
- 1
- Pages
- 73-81
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC5270538
- OpenAlex
- W2550880770
- Cited by
- 76
- References
- 43
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 14 · 2021: 7 · 2020: 12 · 2019: 6 · 2018: 8
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Shandong Province (ZR2014HM087)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- cancer-associated fibroblasts, colorectal cancer, oxidative stress, autophagy, tumor microenvironment, tumor cell proliferation, cancer metabolism
- MeSH terms
- Cancer-Associated Fibroblasts, Acetylcysteine, Adenine, Autophagy, Cell Survival, Humans, Blotting, Western, Colorectal Neoplasms, Oxidative Stress, Coculture Techniques, Cell Line, Tumor, Cell Proliferation
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