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LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival

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Abstract 5110: Cancer-associated fibroblast phenotypes vary across colorectal cancers and correlate with CD8+ T-cell infiltration

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482P Identification of proteome and secretome signatures in primary colorectal cancer associated fibroblasts

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The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review

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The diverse nature of intestinal fibroblasts in development, homeostasis, and disease

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Mechanisms and Strategies to Overcome Drug Resistance in Colorectal Cancer

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Cancer stem cells and their niche in cancer progression and therapy

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Biomarkers of Response and Resistance to Immunotherapy in Microsatellite Stable Colorectal Cancer: Toward a New Personalized Medicine

Huyghe, N. D., Benidovskaya, E., Stevens, P., & den Eynde, M. V. (2022) · Cancers · doi:10.3390/cancers14092241 · Cited by 63 · see citing works

Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance

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Identification and validation of immunotherapy for four novel clusters of colorectal cancer based on the tumor microenvironment

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Cancer-Associated Fibroblasts: The Origin, Biological Characteristics and Role in Cancer—A Glance on Colorectal Cancer

Fotsitzoudis, C., Koulouridi, A., Messaritakis, I., Konstantinidis, T., Gouvas, N., Tsiaoussis, J., & Souglakos, J. (2022) · Cancers · doi:10.3390/cancers14184394 · Cited by 46 · see citing works

From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies

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Epigallocatechin‑3‑gallate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancer‑associated fibroblasts

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Innovative Strategies to Combat 5-Fluorouracil Resistance in Colorectal Cancer: The Role of Phytochemicals and Extracellular Vesicles

Barathan, M., Zulpa, A. K., Ng, S. L., Lokanathan, Y., Ng, M. H., & Law, J. X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137470 · Cited by 43 · see citing works

The Expression Pattern of Bcl-2 and Bax in the Tumor and Stromal Cells in Colorectal Carcinoma

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Early-Onset colorectal Cancer: From the laboratory to the clinic

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Intimate communications within the tumor microenvironment: stromal factors function as an orchestra

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Immune checkpoint inhibitors as mediators for immunosuppression by cancer-associated fibroblasts: A comprehensive review

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The Prognostic and therapeutic value and clinical implications of fibroblast activation protein-α as a novel biomarker in colorectal cancer

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Therapeutic Potential of Naturally Occurring Small Molecules to Target the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer

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Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment

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Immunotherapy with STING and TLR9 agonists promotes synergistic therapeutic efficacy with suppressed cancer-associated fibroblasts in colon carcinoma

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Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine

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Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

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Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities

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Liquid biopsy approaches and immunotherapy in colorectal cancer for precision medicine: Are we there yet?

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Cancer-Associated Fibroblasts in Gastrointestinal Cancers: Unveiling Their Dynamic Roles in the Tumor Microenvironment

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Exploring the efficacy of FAPI PET/CT in the diagnosis and treatment management of colorectal cancer: a comprehensive literature review and initial experience

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Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer

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Crosstalk between colorectal cancer cells and cancer-associated fibroblasts in the tumor microenvironment mediated by exosomal noncoding RNAs

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Deep immunophenotyping reveals clinically distinct cellular states and ecosystems in large-scale colorectal cancer

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Investigating the effect of Fusobacterium nucleatum on the aggressive behavior of cancer-associated fibroblasts in colorectal cancer

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SERPINE1 drives molecular synergies in colorectal cancer

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Fluorescence-guided tumor visualization of colorectal cancer using tumor-initiating probe yellow in preclinical models

Kim, S. Y., Kim, J., Kim, H., Chang, Y., Kwon, H.-Y., Lee, J. L., Yoon, Y. S., Kim, C. W., Hong, S., Shin, J.-H., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-76312-1 · Cited by 6 · see citing works

Type 2 Diabetes Mellitus Promotes the Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells into Cancer-Associated Fibroblasts, Induced by Breast Cancer Cells

Chang, Y.-H., Ngo, N.-H., Khánh, V. C., Yamashita, T., Osaka, M., Hiramatsu, Y., & Ohneda, O. (2022) · Stem Cells and Development · doi:10.1089/scd.2022.0086 · Cited by 6 · see citing works

Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy

Ying, L., Zhu, Y., Zhang, L., Ji, M., Wang, M., Dong, L., Yun, Z., Chen, Y., Zhou, J., Huang, C., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08009-w · Cited by 5 · see citing works

A Subset of Colon Cancer Cell Lines Displays a Cytokine Profile Linked to Angiogenesis, EMT and Invasion Which Is Modulated by the Culture Conditions In Vitro

Bersano, J., Lashuk, K., Edinger, A., & Schüler, J. B. (2023) · Cells · doi:10.3390/cells12212539 · Cited by 5 · see citing works

Comprehensive review on immunotherapy for hepatocellular carcinoma: Current status and future perspectives

Pulakuntla, S., Kuruvalli, G., Mohan, M. C., Nagajyothi, P. C., Shim, J., & Reddy, V. D. (2026) · International Reviews of Immunology · doi:10.1080/08830185.2026.2614779 · Cited by 4 · see citing works

Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer

Strating, E., van de Loo, A., Elias, S. G., Lam, M. G. E. H., & Kranenburg, O. (2023) · PET Clinics · doi:10.1016/j.cpet.2023.02.003 · Cited by 4 · see citing works

Cancer Stem Cells in Colorectal Cancer: Implications for Targeted Immunotherapies

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The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional profilingPreprint

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Mapping and tracing Grem1+ stromal cells in an ApcMin/+ mouse utilizing cryopreserved intestinal sections prepared via modified Swiss-roll technique

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Cancer‑associated fibroblasts in human malignancies, with a particular emphasis on sarcomas (Review)

Benešová, I., Kalkusova, K., Kwon, Y., Táborská, P., Stakheev, D., Krausová, K., Smetanová, J., Ozaniak, A., Bartůňková, J., Smrž, D., et al. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5785 · Cited by 2 · see citing works

Primary Intestinal Fibroblasts: Isolation, Cultivation, and Maintenance

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One Mutation to Rule Them All: Mutant KRAS Controls Tumor Intrinsic and Microenvironment Signaling

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L1CAM EXPRESSION IN THE PERITUMORAL STROMAL CELLS OF THE MICROENVIRONMENT OF COLORECTAL CANCER: A NEW TARGET FOR ONCOLOGISTS?

Cau, F., Gerosa, C., Ziranu, P., Pretta, A., Piras, M., Fraschini, M., Eyken, P. V., Nasa, G. L., Castagnola, M., Coghe, F., et al. (2023) · Annals of Research in Oncology · doi:10.48286/aro.2023.76 · Cited by 2 · see citing works

Mitochondrial Metabolic Reprogramming in Colorectal Cancer-Associated Fibroblasts: An Up-to-Date Review

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Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor MicroenvironmentsPreprint

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Fibroblasts drive differential response in immunotherapy via IL-6 in bioengineered 3D cancer constructsPreprint

Chakraborty, S., Rodriguez, M., & Skardal, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.18.660473 · Cited by 1 · see citing works

The Role of Tumor Microenvironment in Colon Cancer

Fattorini, C., Arganini, M., Cavazzana, A. O., & Ambrosio, M. R. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_26

A multi-model study of extracellular vesicles in bowel cancer invasion and metastasis

Guarnerio, S. (2023) · Sheffield Hallam University · doi:10.7190/shu-thesis-00581

Identification and Validation of Mitophagy‐Related Biomarkers in Colorectal Cancer: An Integrated Analysis of Single‐Cell Transcriptome and Mendelian Randomization

Zhao, J., Kong, M., Wang, S., Cao, Z., & Tian, X. (2026) · Genetics Research · doi:10.1155/genr/5579542

Colorectal Cancer and the Enigma Surrounding Non-Canonical Wnt Signaling

Kita, K. (2026) · Cancers · doi:10.3390/cancers18162618

Engineered SERPINE1 Overexpression Activates the pp53/p21 Pathway and Promotes a Growth-Restricted, Migratory Phenotype in KRAS-Transformed Renal Proximal Tubular Cells

Nuha, N., Higgins, C. E., Higgins, S. P., Samarakoon, R., & Higgins, P. J. (2026) · Biomolecules · doi:10.3390/biom16101517

Role of cancer-associated fibroblasts in colorectal cancer and their potential as therapeutic targets

Yan, L., Zheng, J., Wang, Q., & Hao, H. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.09.065 · Cited by 17 · see citing works

Cancer-Associated Fibroblasts: The Origin, Biological Characteristics and Role in Cancer—A Glance on Colorectal Cancer

Fotsitzoudis, C., Koulouridi, A., Messaritakis, I., Konstantinidis, T., Gouvas, N., Tsiaoussis, J., & Souglakos, J. (2022) · Cancers · doi:10.3390/cancers14184394 · Cited by 46 · see citing works

Targeting the devil: Strategies against cancer-associated fibroblasts in colorectal cancer

Chen, Y., Liang, Z., & Lai, M. (2024) · Translational research · doi:10.1016/j.trsl.2024.04.003 · Cited by 41 · see citing works

Unraveling the role of cancer-associated fibroblasts in colorectal cancer

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Molecular features and clinical significance of cancer-associated fibroblasts in colorectal cancer

Yin, Y., Liu, H., Wu, S., Fu, Y., & Peng, S. (2026) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-10-0476