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Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
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Starvation-induced lipid droplets are prevented by inhibiting lysosomal acidification and degradative function with bafilomycin A1.
“Previous work found that starvation-induced lipid droplets are prevented by inhibiting lysosomal acidification and degradative function with bafilomycin A1 12,34 .”
From ApoE4 impairs astrocyte lipid droplet formation via endolysosomal dysfunction (2026) · cites this paper as [34]
Blocking autophagic flux by Bafilomycin A1 increases tau and lysosomal lipid accumulation, while increased cholesterol and CE impairs autophagy function and tau degradation.
“Blocking autophagic flux by Bafilomycin A1 increases tau and lysosomal lipid accumulation84, while increased cholesterol and CE impairs autophagy function and tau degradation18,27.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [84]
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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
Poggio, M., Hu, T., Pai, C.-C., Chu, B., Belair, C. D., Chang, A., Montabana, E., Lang, U. E., Fu, Q., Fong, L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.016 · Cited by 1,376
Dual role of autophagy in hallmarks of cancer
Singh, S. S., Vats, S., Chia, A. Y.-Q., Tan, T. Z., Deng, S., Ong, M. S., Arfuso, F., Yap, C. T., Goh, B. C., Sethi, G., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0046-6 · Cited by 542
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
Li, X., Rydzewski, N., Hider, A., Zhang, X., Yang, J., Wang, W., Gao, Q., Cheng, X., & Xu, H. (2016) · Nature Cell Biology · doi:10.1038/ncb3324 · Cited by 387
Targeting lysosomes in human disease: from basic research to clinical applications
Cao, M., Luo, X., Wu, K., & He, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00778-y · Cited by 225
Schäffner, I., Minakaki, G., Khan, M. A., Balta, E.-A., Schlötzer-Schrehardt, U., Schwarz, T. J., Beckervordersandforth, R., Winner, B., Webb, A. E., DePinho, R. A., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.017 · Cited by 145
“BafilomycinA1 (BafA1) disrupts ALP activity by inhibiting V-ATPase-dependent acidification and autophagosome-lysosome fusion (Mauvezin and Neufeld, 2015) and results in accumulation of autophagy substrates including LC3 and p62.”
Chen, Y., Wang, H., Ying, Z., & Gao, Q. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.051 · Cited by 63
Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time
Prakash, P., Jethava, K. P., Korte, N., Izquierdo, P., Favuzzi, E., Rose, I. V. L., Guttenplan, K. A., Manchanda, P., Dutta, S., Rochet, J.-C., et al. (2021) · Chemical Science · doi:10.1039/d1sc03486c · Cited by 45
Balsamo, J. A., Penton, K. E., Zhao, Z., Hayes, M. J., Lima, S. M., Irish, J. M., & Bachmann, B. O. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102300 · Cited by 12
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Acosta Ingram, D., Turkes, E., Kim, T. Y., Vo, S., Sweeney, N., Bonte, M.-A., Rutherford, R., Julian, D. L., Pan, M., Marsh, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58585-w · Cited by 12
Bakadlag, R., Limniatis, G., Georges, G., & Georges, E. (2023) · BMC Cancer · doi:10.1186/s12885-022-10474-x · Cited by 9
ApoE4 impairs astrocyte lipid droplet formation via endolysosomal dysfunction
Ralhan, I., Bae, J.-Y., Lee, N. Y., Cai, W., Chang, J., Jarad, S., Gu, H., Zhang, D., & Ioannou, M. S. (2026) · doi:10.64898/2026.09.01.748585
Metadata
- Authors
- Mauvezin, C., & Neufeld, T. P.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2015-08-03
- Volume
- 11
- Issue
- 8
- Pages
- 1437-1438
- ISSN
- 1554-8627
- 1554-8635
- Cited by
- 817
- References
- 0
- Language
- en
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