The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
ER stress: Autophagy induction, inhibition and selection
Open accessAbstract
An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic intracellular signaling network cumulatively called the unfolded protein response (UPR), which orchestrates the recuperation of ER function. Macroautophagy (hereafter autophagy), an intracellular lysosome-mediated bulk degradation pathway for recycling and eliminating wornout proteins, protein aggregates, and damaged organelles, has also emerged as an essential protective mechanism during ER stress. These 2 systems are dynamically interconnected, and recent investigations have revealed that ER stress can either stimulate or inhibit autophagy. However, the stress-associated molecular cues that control the changeover switch between induction and inhibition of autophagy are largely obscure. This review summarizes the crosstalk between ER stress and autophagy and their signaling networks mainly in mammalian-based systems. Additionally, we highlight current knowledge on selective autophagy and its connection to ER stress.
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Cites
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Zhang, C., Xu, C., Gao, X., & Yao, Q. (2022) · Theranostics · doi:10.7150/thno.69424 · Cited by 1,018
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
Ren, J., Bi, Y., Sowers, J. R., Hetz, C., & Zhang, Y. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00511-w · Cited by 708
2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
Pajak, B., Siwiak, E., Sołtyka, M., Priebe, A., Zieliński, R., Fokt, I., Ziemniak, M., Jaśkiewicz, A., Borowski, R., Domoradzki, T., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010234 · Cited by 574
Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases
Cybulsky, A. V. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.129 · Cited by 526
Li, Y., Li, S., & Wu, H. (2022) · Cells · doi:10.3390/cells11050851 · Cited by 367
Metadata
- Authors
- Rashid, H.-O., Yadav, R. K., Kim, H.-R., & Chae, H.-J.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2015-11-02
- Volume
- 11
- Issue
- 11
- Pages
- 1956-1977
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2168453644
- Cited by
- 795
- References
- 38
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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