TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation

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Excessive Lysosomal Stress Response and Consequently Impaired Autophagy Contribute to Fluoride-Induced Developmental Neurotoxicity

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ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis

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Bafilomycin A1 Molecular Effect on ATPase Activity of Subcellular Fraction of Human Colorectal Cancer and Rat Liver

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Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells

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Long-chain fatty acids - The turning point between ‘mild’ and ‘severe’ acute pancreatitis

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Cross-species metabolomic profiling reveals phosphocholine-mediated liver protection from cold and ischemia/reperfusion

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Sesamin alleviates lipid accumulation induced by elaidic acid in L02 cells through TFEB regulated autophagy

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Knockdown of TXNIP alleviates gestational diabetes mellitus by activating autophagy to regulate cell proliferation and apoptosis in high glucose-treated trophoblasts

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Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting

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Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation

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The TXNIP–mTOR–Autophagy axis in diabetic kidney disease: mechanistic insights and therapeutic implications

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Silencing of TXNIP attenuates oxidative stress injury in HEI-OC1 by inhibiting the activation of NLRP3 and NF-κB

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Design, synthesis, and biological evaluation of carbonyl-hydrazine-1-carboxamide derivatives as anti-hepatic fibrosis agents targeting Nur77

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Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Swertianin Suppresses M1 Macrophage Polarization and Inflammation in Metabolic Dysfunction-Associated Fatty Liver Disease via PPARG Activation

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Gut microbiota as a metabolic mediator to prevent or attenuate MASLD

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Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene

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The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity

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Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation

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Sulfonated albumin from hepatocytes accelerates liver fibrosis in nonalcoholic fatty liver disease through endoplasmic reticulum stress

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METTL3 inhibits liver fibrosis via RBX1 stability and TXNIP-mediated ferroptosis

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Activation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury

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Targeting microglial inflammation in Parkinson’s disease: irisin activates PAFAH1B1-RAGE ubiquitination and TFEB-dependent autophagy to alleviate neurodegeneration

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The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

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Alisol B alleviates MASLD by activating liver autophagy and fatty acid oxidation via Ces2a

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Licochalcone A promotes autophagy to ameliorate NAFLD by inhibiting the mTOR and regulating ULK1/Beclin1/VPS34 pathway

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Knockdown of MiD49 and MiD51 alleviates collagen-induced arthritis and suppresses mitophagy and fatty acid oxidation (FAO) in rheumatoid arthritis fibroblast-like synoviocytes

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Dysregulated autophagic activity induced in response to chronic intermittent hypoxia contributes to the pathogenesis of NAFLD

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Exogenous galanin alleviates hepatic steatosis by promoting autophagy via the AMPK-mTOR pathway

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FOXA1-Driven pathways exacerbate Radiotherapy-Induced kidney injury in colorectal cancer

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The absence of thioredoxin-interacting protein in alveolar cells exacerbates asthma during obesity

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Identification and Evaluation of Hub Long Noncoding RNAs and mRNAs in High Fat Diet Induced Liver Steatosis

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F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit

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Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease

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Mitochondrial Dysfunction in Metabolic-Syndrome-Related MASLD/MASH: Metabolic Mechanisms and Therapeutic Perspectives

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Dysregulated mTOR signaling in Alzheimer's disease: Linking pathogenic mechanisms to emerging therapeutic strategies

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Cell-specific roles of autophagy in liver fibrosis: implications for targeted pharmacotherapy

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Transcriptome Sequencing Reveals Autophagy Networks in Rat Livers During the Development of NAFLD and Identifies Autophagy Hub Genes

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FBXL5 promotes lipid accumulation in alcoholic fatty liver disease by promoting the ubiquitination and degradation of TFEB

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Molecular Regulation of Transforming Growth Factor-β1-induced Thioredoxin-interacting Protein Ubiquitination and Proteasomal Degradation in Lung Fibroblasts: Implication in Pulmonary Fibrosis

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Study on the susceptibility of bovine coronavirus to BALB/c mice

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ESRRA (estrogen related receptor, alpha) induces ribosomal protein RPLP1-mediated adaptive hepatic translation during prolonged starvation

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Deciphering significances of autophagy in the development and metabolism of adipose tissue

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SIRT2-dependent CPT1A deacetylation in macrophages inhibits periodontitis

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Dual AMPK activation and TXNIP suppression underlie the superior anti-diabetic action of rosiglitazone-metformin co-crystal (RZM): evidence from preclinical models

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Downregulation of HDAC9 Alleviates Autophagy Dysfunction by Inducing Acetylation of ATG4B in Metabolic Dysfunction‐Associated Steatotic Liver Disease

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Chaize mixture alleviates NAFLD by regulating Glipr2-related autophagy/NLRP3 signaling

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Gigantol Ameliorates Metabolic Dysfunction-Associated Steatohepatitis by Promoting TFEB-Mediated Lipophagy and Fatty Acid Oxidation

Zhang, C., Luo, Y., Xiong, Y., Chen, L., Zhao, H., Qiu, Z., & Yang, Y. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09366 · Cited by 3

Supplementation of L-aspartate corrects MASLD and MASH in mice by inhibiting platelet–hepatocyte interaction-mediated mitochondrial fragmentation via the ATP–P2X7–NEK7–DRP1 axis

Cao, W.-J., Su, R., Fu, H.-L., Wu, J.-J., Huang, L.-S., Liu, F.-F., Liu, J., Jiang, Z.-P., Xu, C.-J., Rao, Y., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01648-9 · Cited by 4

Chronic rapamycin treatment decreases hepatic IL ‐6 protein, but increases autophagy markers as a protective effect against the overtraining‐induced tissue damage

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Drug targets regulate systemic metabolism and provide new horizons to treat nonalcoholic steatohepatitis

Wang, Y., Yu, H., Cen, Z., Zhu, Y., & Wu, W. (2023) · Metabolism Open · doi:10.1016/j.metop.2023.100267 · Cited by 3

LncRNA AC005165.1 Alleviates IL-1β-Induced Osteoarthritis via miR-199a-3p/TXNIP Axis

Gu, X., & Xie, T. (2024) · Biochemical Genetics · doi:10.1007/s10528-024-10720-w · Cited by 3

Identification of genetic markers associated with hyperketonemia patterns in early lactation Holstein cows

Muniz, M. M. M., Serrenho, R. C., Duffield, T. F., Júnior, G. A. O., McArt, J. A. A., Baes, C. F., Schenkel, F. S., & Squires, E. J. (2024) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12875 · Cited by 3

VDUP1 Deficiency Promotes the Severity of DSS-Induced Colitis in Mice by Inducing Macrophage Infiltration

Park, K. H., Lee, H., Kim, H.-C., Choi, I., Han, S., & Kang, J. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713584 · Cited by 3

Dietary Polyunsaturated Fatty Acid Deficiency Impairs Renal Lipid Metabolism and Adaptive Response to Proteinuria in Murine Renal Tubules

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Efficacy and mechanism of iridoid glycosides from Gentianella turkestanorum (Gand.) Holub on non-alcoholic steatohepatitis based on RNA sequencing

Zheng, D.-X., Ju, B., Wen, L., Xiang, X.-Y., Xue, T., Dai, W., Liu, J., Hu, J., & Yang, J. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119888 · Cited by 2

Gut Microbiota-Targeted Intervention of Hyperlipidemia Using Monascus-Fermented Ginseng

Zhou, Q., Yang, C., Jia, M., Qu, Q., Peng, X., Ren, W., Li, G., Xie, Y., Li, B., & Shi, X. (2025) · Pharmaceuticals · doi:10.3390/ph18050661 · Cited by 2

Homoharringtonine exerts anti-silicosis effects by inhibiting the CCR1 and PI3K/AKT signaling pathways in lung fibroblasts

Jia, X., Li, Z., Hu, X., Wang, T., Lian, W., Sun, W., Liu, Y., & Ni, C. (2025) · Journal of Biomedical Research · doi:10.7555/jbr.39.20250074 · Cited by 2

Understanding the Mechanisms of Lipid Metabolism Reprogramming and Ferroptosis in Diabetic Kidney Disease Progression

Han, Y. Z., Zhu, X. Y., Wang, Y. Z. Y., Du, B. X., Zhou, Y. Q., Zhang, X., Wang, Y., Zheng, H., & Liu, W. J. (2025) · Journal of Food Biochemistry · doi:10.1155/jfbc/8388326 · Cited by 2

Integrated proteomic and metabolomic analysis reveals lipid metabolic dysregulation and ferroptosis as potential drivers of placental dysfunction in intrahepatic cholestasis of pregnancy

Dong, R., Wang, G., Shi, Y., Gao, J., Hu, W.-L., & Zhang, T. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2025.159692 · Cited by 2

Naringin mitigates liver damage in a tissue-engineered liver of metabolic dysfunction-associated steatotic liver disease model by promoting autophagy via the mTOR-ULK1 pathway

Jia, J., Zhang, Y., Lin, J., Duan, Z., Chen, Y., & Zhang, X. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11102-0 · Cited by 2

Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model

Liu, Q., Du, Q., Yuan, X., Zhang, T., Li, J., Xu, J., & Xie, R. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s539555 · Cited by 2

Metabolic insults-initialised nonalcoholic steatohepatitis promoted by fine particulate matter challenge: A mechanism involving RNF15-driven ASK1 degradation

Chang, M., Zhao, J., Fan, H., Shi, Z., Xu, M., Ge, C., Zhu, L., Tan, J. R., & Meng, D. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.032 · Cited by 2

Maternal effects of choline on skeletal muscle development and intramuscular fat deposition in broiler offspring

Gao, M., Han, Q., Zhu, Q., Li, D., Li, X., Lv, Z., & Guo, Y. (2025) · Poultry Science · doi:10.1016/j.psj.2025.106104 · Cited by 2

FTO-mediated m6A demethylation of BECN1 mRNA promotes hepatic steatosis by impairing autophagy

Liu, L., & Ji, B. (2025) · BMC Immunology · doi:10.1186/s12865-025-00784-7 · Cited by 2

Bufotenidine attenuates astrocyte ferroptosis in depressive-like behaviors through targeting GluA1 to reduce neuronal lipid synthesis

Wu, W., Chen, Z., Xu, Y., Xie, X., Tan, A., Hu, M., Xu, D., Lv, X., Chen, W., Zhou, J., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.03.024 · Cited by 2

Targeting TXNIP for neuroprotection: A novel approach to reducing inflammation and promoting recovery in ischemic stroke

He, C., Bao, Y., Xu, Y., Cheng, J., & Hu, X. (2024) · Biomolecules and Biomedicine · doi:10.17305/bb.2024.11366 · Cited by 2

Targeting Methionine Metabolism Reveals AMPK-SAMTOR Signaling as a Therapeutic Vulnerability in Prostate Cancer

Arısan, S., Sever, A., Yerlikaya, P. O., Arısan, E. D., & Onganer, P. U. (2025) · Biology · doi:10.3390/biology14050507 · Cited by 2

Estrogen receptor-related receptor (Esrra) induces ribosomal protein Rplp1-mediated adaptive hepatic translation during prolonged starvationPreprint

Tripathi, M., Gauthier, K. C., Sandireddy, R., Zhou, J., Gupta, P. S., Sakthivel, S., Jiemin, N., Arul, K., Tikno, K., Park, S.-H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.09.574937 · Cited by 2

C23 ameliorates carbon tetrachloride-induced liver fibrosis in mice

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HNMT Promotes the Occurrence and Progression of Nasopharyngeal Carcinoma by Inhibiting the IFN/TXNIP/p53 Axis

Cheng, S., Wu, X., Sun, W.-D., Hong, Z., Liu, X., Jiang, C.-W., & Ruan, B. (2025) · Current Medical Science · doi:10.1007/s11596-025-00072-w · Cited by 1

Melatonin regulates accumulation of lipids in the liver via the IP3R on the mitochondria-associated membranes (MAMs)

Jin, M., Yu, H., Wei, Y., Ma, X., Deng, X., Wang, J.-F., & Feng, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112109 · Cited by 1

PM2.5 exacerbate nonalcoholic fatty liver disease through activating hepatocytes TXNIP/NLRP3/FoxO1 signaling pathway in ob/ob mice

Li, T., Gao, S., Zeng, Y. Y., Lin, L., Li, T., Sun, Z., & Yu, Y. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.027 · Cited by 1

ATP6V0d2 alleviates acute liver injury via promoting hepatocyte autophagy

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Thioredoxin-interacting protein in radiation-induced pyroptosis and autophagy: Unveiling mechanisms and implications for preventing radiation-induced lung injury

Liu, T., Wang, X. B., Yin, Q., Zhang, S. H., Zhang, T., Deng, S. H., Fei, Y. D., Wu, D. M., Zhang, T., & Xu, Y. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150650 · Cited by 1

Qushi Huoxue ointment ameliorates metabolic associated steatotic liver disease through autophagy activation and ferroptosis inhibition

Liu, Y.-Y., Qin, H. X., Wu, H., Ru-Ting, W. A. N. G., Yang, Q.-Y., Jiang, F., Liu, X.-D., Wu, D.-K., & Tang, Y.-M. (2026) · World Journal of Hepatology · doi:10.4254/wjh.v18.i2.115763 · Cited by 1

Atg2 coordinates microbial metabolite signaling and epigenetic remodeling to maintain intestinal lipid homeostasis in Drosophila

Wang, P., Li, X., Zhang, J., Wang, J., & Jin, L. H. (2026) · Microbiome · doi:10.1186/s40168-026-02356-2 · Cited by 2

Population-scale characterization of the oral microbiome and associations with metabolic health

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Thioredoxin-interacting protein in fibrotic diseases: Mechanisms and therapeutic strategies

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Rapamycin did not prevent the excessive exercise-induced hepatic fat accumulation

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Sodium Orthovanadate Mitigates Nonalcoholic Fatty Liver Disease by Enhancing Autophagy

Zhang, X., Zhou, H., Kong, Z., Li, T., Zhu, C., Tang, W., Qin, X., & Tang, L. (2024) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00355 · Cited by 1

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fastingPreprint

Tripathi, M., Gauthier, K. C., Sandireddy, R., Zhou, J., Gupta, P. S., Sakthivel, S., Teo, W. W., Naing, Y. T., Arul, K., Tikno, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.16.468891 · Cited by 1

TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver diseasePreprint

Jung, E., Baek, E. B., Hong, E.-J., Kang, J. H., Park, S., Hong, E., Cho, Y., Ko, J., Won, Y., & Kwon, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.30.526192 · Cited by 1

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Harnessing the crosstalk of adipocytes, autophagy, and immune cells for immunotherapy in obesity

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Research Progress on Co-Pathogenesis of Non-Alcoholic Fatty Liver Disease and Sarcopenia

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Thioredoxin-interacting protein TXNIP as a promising diagnostic marker for metabolic-associated fatty liver disease in patients with type 2 diabetes

Робертовна, М. А., Laevskaya, M. Y., Николаевич, С. Ю., & Babenko, A. Y. (2025) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2024-532

The Role of Lipotoxicity in Diabetic Nephropathy: From Physiologic Mechanisms to Therapeutic Perspectives

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Hif-1α-Bnip3 Restores Pparα-Mediated Fatty Acid Oxidation Through Pi3k-Iii Complex-Mediated Autophagy Following Renal Ischemia-Reperfusion InjuryPreprint

Wang, Z., Wang, C., Fu, Z., Xu, L., Xu, J., Ma, H., Feng, X., Han, W., & Zhang, W. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5385773

Integrated network pharmacology and in vivo experimental approaches unveil the modulatory effect of telmisartan on autophagy in a rat model of nonalcoholic steatohepatitis

Metwally, S. S., Abdel-Ghany, R. H., El-Gharbawy, A., Mohsen, M. A., Alsemeh, A. E., & Zakaria, E. M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178136

Additional file 2 of PTBP1 knockdown impairs autophagy flux and inhibits gastric cancer progression through TXNIP-mediated oxidative stress

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Additional file 1 of PTBP1 knockdown impairs autophagy flux and inhibits gastric cancer progression through TXNIP-mediated oxidative stress

Wang, S., Wang, X., Qin, C., Liang, C., Li, W., Ran, A., Ma, Q., Pan, X., Yang, F., Ren, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26771730

Additional file 4 of PTBP1 knockdown impairs autophagy flux and inhibits gastric cancer progression through TXNIP-mediated oxidative stress

Wang, S., Wang, X., Qin, C., Liang, C., Li, W., Ran, A., Ma, Q., Pan, X., Yang, F., Ren, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26777998

Additional file 1 of A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain

Li, K., Yang, W., Chen, X., Yu, Y., Liu, Y., Ni, F., Xiao, Y., Qing, X., Liu, S., He, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26777260

Additional file 1 of Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice

Xue, X., Wang, L., Wu, R., Li, Y., Liu, R., Ma, Z., Jia, K., Zhang, Y., & Li, X. (2024) · Figshare · doi:10.6084/m9.figshare.26730670

Inhibition of ? 24-dehydrocholesterol reductase ameliorates non-alcoholic steatohepatitis in mice

Nakashima, H., Zhou, E., van der Zande, P., Li, Z., Steenvoorden, E., Müller, C., Giera, M. A., Guigas, B., Bracher, F., Rensen, P. C. N., et al. (2020) · Journal of Hepatology · doi:10.1016/s0168-8278(20)30715-7

Macrophage‐Specific Hypoxia‐Inducible Factor‐1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Wang, X., Ribeiro, M. D. C., Iracheta‐Vellve, A., Lowe, P., Ambade, A., Satishchandran, A., Bukong, T. N., Catalano, D., Kodys, K., & Szabó, G. (2018) · Hepatology · doi:10.1002/hep.30215 · Cited by 149

Hepatic autophagy fluctuates during the development of non-alcoholic fatty liver disease

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Reduced Lysosomal Acidification Induce p53 and Unfolded Protein Response in Mice With Nutritional Steatohepatitis

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