The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases
Abstract
INTRODUCTION: Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. AREAS COVERED: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis. EXPERT OPINION: Generally, the size, shape, and density of a particle affect its adhesion to vascular walls synergistically, and these three factors should be considered simultaneously when designing an optimal carrier for targeting CVD. Available preliminary data should encourage more studies to be conducted to investigate the use of nano-constructs, characterized by a sub-micrometer size, a non-spherical shape, and a high material density to maximize vascular wall margination and minimize capillary entrapment, as carriers for targeting CVD.
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The present model could not fully represent the complexity of biological systems (e.g., lack of plasma proteins or circulating blood cells) that are known to affect NP properties and nanobio interactions.
“Although the present model could not fully represent the complexity of biological systems (e.g., lack of plasma proteins or circulating blood cells) that are known to a ff ect NP properties and nanobio interactions, 70,71”
From Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model (2019) · cites this paper as [71]
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- Authors
- Ta, H. T., Truong, N. P., Whittaker, A. K., Davis, T. P., & Peter, K.
- Affiliations
- The University of Queensland (AU)
- Monash University (AU)
- University of Warwick (GB)
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Ta, Hang T.
- Peter, Karlheinz
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2017-04-13
- Volume
- 15
- Issue
- 1
- Pages
- 33-45
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2604413746
- Cited by
- 105
- References
- 112
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 17 · 2020: 13 · 2019: 12 · 2018: 9 · 2017: 4
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion)
- Warwick Research Archive Portal (University of Warwick) (submittedVersion)
- Funders
- Australian Research Council (CE140100036)
- National Health and Medical Research Council (APP1037310, FT0992210)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- vascular wall, atherosclerosis, particle size, particle shape, particle density, hemorheology, endothelial cell adhesion, cardiovascular disease
- MeSH terms
- Coronary Artery Disease, Coronary Vessels, Densitometry, Drug Carriers, Endothelium, Vascular, Hemodynamics, Humans, Particle Size, Drug Delivery Systems
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