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Cited by 25Immunotoxicology and immune responsesNanoparticles: synthesis and applicationsNeuroinflammation and Neurodegeneration Mechanisms

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Pretreatment with N-acetyl cysteine suppresses chronic reactive astrogliosis following maternal nanoparticle exposure during gestational period

Onoda, Atsuto, Takeda, Ken, Umezawa, Masakazu·2017·Nanotoxicology
DOI 10.1080/17435390.2017.1388864
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Abstract

Early pregnant employees are potentially and unintendedly exposed to industrial chemicals including nanoparticles. Developmental toxicity of nanoparticle exposure has been concerned because exposure to fine particle including carbon black nanoparticle (CB-NP) during the brain developmental stage enhances the risk of brain disorders. Maternal CB-NP exposure dose-dependently induces astrogliosis, which is an abnormal increase in the reactive astrocytes with glial fibrillary acidic protein (GFAP) and aquaporin-4 overexpression due to the destruction of nearby neurons and blood vessels. The present study aimed to investigate protective effects of antioxidants on the histopathological denaturation with astrogliosis following maternal CB-NP exposure in offspring mice, thereby to evaluate the role of oxidative stress on the developmental toxicity. Pregnant ICR mice were treated with CB-NP by intranasal instillation on gestational days 5 and 9. N-acetyl cysteine (NAC) or ascorbic acid was intraperitoneally administered to the pregnant mice 1 h prior to CB-NP instillation. The brains were collected from 6- to 12-week-old offspring mice and analyzed using western blotting and immunohistochemistry. NAC suppressed GFAP overexpression in 6- and 12-week-old offspring mice following maternal CB-NP exposure. However, NAC did not suppress aquaporin-4 overexpression following maternal CB-NP exposure. Ascorbic acid did not suppress, but rather slightly and significantly enhanced the expression…

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Metadata

Authors
Onoda, A., Takeda, K., & Umezawa, M.
Affiliations
Tokyo University of Science (JP)
Corresponding author
Onoda, Atsuto
ORCID
Venue
Nanotoxicology
Publisher
Informa UK Limited
Published
2017-09-14
Volume
11
Issue
8
Pages
1012-1025
ISSN
  • 1743-5390 (ISSN-L)
  • 1743-5404
DOI
10.1080/17435390.2017.1388864
OpenAlex
W2766699794
Cited by
25
References
2
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 3
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Locations
  • Nanotoxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Grant-in Aid from the MEXT-Supported Program (S1101015, 2011-2015)
  • Japan Society for the Promotion of Science (15J05718, 2015-2017)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
N-acetylcysteine, carbon black nanoparticles, prenatal exposure, reactive astrogliosis, developmental neurotoxicity, oxidative stress, antioxidants, vitamin C, glial fibrillary acidic protein, aquaporin-4, astrocytes, offspring brain
MeSH terms
Acetylcysteine, Administration, Intranasal, Animals, Animals, Newborn, Antioxidants, Astrocytes, Brain, Female, Glial Fibrillary Acidic Protein, Mice, Inbred ICR, Pregnancy, Prenatal Exposure Delayed Effects, Oxidative Stress, Maternal Exposure, Mice, Aquaporin 4, Soot, Nanoparticles

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