Human gut-on-a-chip technology: will this revolutionize our understanding of IBD and future treatments?
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Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), is the devastating chronic inflammation in human intestine, but the exact etiology is largely unknown [1]...
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The 2-channel human Gut Chip was used to coculture multiple commensal microbes in contact with living human intestinal epithelial cells and to analyze how gut microbiome, inflammatory cells, and peristalsis-associated mechanical deformations independently contribute to intestinal bacterial overgrowth and inflammation, which are associated with IBD.
“The 2-channel human Gut Chip was used to coculture multiple commensal microbes in contact with living human intestinal epithelial cells and to analyze how gut microbiome, inflammatory cells, and peristalsis-associated mechanical deformations independently contribute to intestinal bacterial overgrowth and inflammation, which are associated with IBD.42, 66”
From Microfluidic Organ-on-a-Chip Models of Human Intestine (2018) · cites this paper as [66]
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- Authors
- Lee, J., Choi, J.-H., & Kim, H. J.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Kim, Hyun Jung
- Venue
- Expert Review of Gastroenterology & Hepatology
- Publisher
- Informa UK Limited
- Published
- 2016-06-22
- Volume
- 10
- Issue
- 8
- Pages
- 1-3
- ISSN
- 1747-4124 (ISSN-L)
- 1747-4132
- OpenAlex
- W2433601385
- Cited by
- 44
- References
- 23
- Citations by year
- 2024: 5 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 6
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Review of Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Foundation for Ethical Research
- Harvard University
- University of Texas at Austin
- Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- gut-on-a-chip, inflammatory bowel disease, ulcerative colitis, Crohn's disease, intestinal inflammation, disease modeling, in vitro intestinal model, drug development
- MeSH terms
- Gastrointestinal Microbiome, Diffusion of Innovation, Humans, Micromanipulation, Inflammatory Bowel Diseases, Biomimetic Materials, Gastrointestinal Tract, Microchip Analytical Procedures, Lab-On-A-Chip Devices, Translational Research, Biomedical
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