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Systematic review of islet cryopreservation
Open accessAbstract
Pancreatic islet transplantation is being extensively researched as an alternative treatment for type 1 diabetic patients. This treatment is currently limited by temporal mismatch, between the availability of pancreas and isolated islets from deceased organ donor, and the recipient's need for freshly isolated islets. To solve this issue, cryopreservation of islets may offer the potential to bank islets for transplant on demand. Cryopreservation, however, introduces an overwhelmingly harsh environment to the ever-so-fragile islets. After exposure to the freezing and thawing, islets are usually either apoptotic, non-functional, or non-viable. Several studies have proposed various techniques that could lead to increased cell survival and function following a deep freeze. The purpose of this article is to critically review the techniques of islet cryopreservation, with the goal of highlighting optimization parameters that can lead to the most viable and functional islet upon recovery and/or transplant.
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To date, freezing whole islets has been met with challenges.
“To-date, however, freezing whole islets has been met with challenges.185”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [185]
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Rao, J. S., Guo, Z., Khashim, Z., Knofczynski, K. R., Tobolt, D. K., Shivakumar, S. B., Rangarajan, P., Herman, A., Abdulla, M., Tran, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.25.720819
Metadata
- Authors
- Kojayan, G. G., Alexander, M., Imagawa, D. K., & Lakey, J. R. T.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Lakey, Jonathan R. T.
- Venue
- Islets
- Publisher
- Informa UK Limited
- Published
- 2018-01-02
- Volume
- 10
- Issue
- 1
- Pages
- 40-49
- ISSN
- 1938-2014 (ISSN-L)
- 1938-2022
- PMC
- PMC5800373
- OpenAlex
- W2783080681
- Cited by
- 38
- References
- 64
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 8
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Islets (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California, Irvine
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- islet cryopreservation, islet transplantation, type 1 diabetes, islet viability, islet function, freeze-thaw cycles, islet apoptosis, islet survival
- MeSH terms
- Animals, Humans, Islets of Langerhans, Cryopreservation, Islets of Langerhans Transplantation, History, 19th Century, History, 20th Century, History, 21st Century
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