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Potential for enriching next-generation health-promoting gut bacteria through prebiotics and other dietary components
Open accessAbstract
The human intestinal commensal microbiota and associated metabolic products have long been regarded as contributors to host health. As the identity and activities of the various members of this community have become clearer, newly identified health-associated bacteria, such as Faecalibacterium prausnitzii, Akkermansia muciniphila, Ruminococcus bromii and Roseburia species, have emerged. Notably, the abundance of many of these bacteria is inversely correlated to several disease states. While technological and regulatory hurdles may limit the use of strains from these taxa as probiotics, it should be possible to utilize prebiotics and other dietary components to selectively enhance their growth in situ. Dietary components of potential relevance include well-established prebiotics, such as galacto-oligosaccharides, fructo-oligosaccharides and inulin, while other putative prebiotics, such as other oligosaccharides, polyphenols, resistant starch, algae and seaweed as well as host gut metabolites such as lactate and acetate, may also be applied with the aim of selectively and/or differentially affecting the beneficial bacterial community within the gastrointestinal environment. The present review provides an overview of the dietary components that could be applied in this manner.
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“Nevertheless, technological advances have expanded the targets of prebiotics beyond Lactobacillus and Bifidobacterium, to other newly identified health-promoting gut microbes, such as Roseburia, Eubacterium, and Faecalibacterium spp.715,716”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [716]
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Metadata
- Authors
- Lordan, C., Thapa, D., Ross, R. P., & Cotter, P. D.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Corresponding author
- Cotter, Paul D.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2019-05-22
- Volume
- 11
- Issue
- 1
- Pages
- 1-20
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC6973326
- OpenAlex
- W2946614008
- Cited by
- 289
- References
- 125
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 47 · 2023: 38 · 2022: 58 · 2021: 54 · 2020: 26 · 2019: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Funders
- Department of Agriculture, Food and the Marine (Grant no. 15/F/635)
- APC Microbiome Ireland (SFI/12/RC/2273)
- Teagasc (Grant no. 2017047)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- prebiotics, gut microbiota, health-promoting bacteria, Faecalibacterium prausnitzii, Akkermansia muciniphila, Ruminococcus bromii, Roseburia, food components, galactooligosaccharides, fructooligosaccharides, inulin, polyphenols, resistant starch, algae, seaweed, lactate, acetate, probiotics
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Diet, Humans, Minerals, Oligosaccharides, Seaweed, Dietary Supplements, Probiotics, Gastrointestinal Tract, Prebiotics, Polyphenols
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