The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Diversification of host bile acids by members of the gut microbiota
Open accessAbstract
Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host hepatocytes synthesize primary bile acids from cholesterol. Once these host-derived primary bile acids enter the gastrointestinal tract, the gut microbiota chemically modify them into secondary bile acids. Interest into the gut-bile acid-host axis is expanding in diverse fields including gastroenterology, endocrinology, oncology, and infectious disease. This review aims to 1) describe the physiologic aspects of collaborative bile acid metabolism by the host and gut microbiota; 2) to evaluate how gut microbes influence bile acid pools, and in turn how bile acid pools modulate the gut microbial community structure; 3) to compare species differences in bile acid pools; and lastly, 4) discuss the effects of ursodeoxycholic acid (UDCA) administration, a common therapeutic bile acid, on the gut microbiota-bile acid-host axis.
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Cites
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Cited by
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives
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Rethinking healthy eating in light of the gut microbiome
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Metabolic Messengers: bile acids
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Interactive relationships between intestinal flora and bile acids
Guo, X., Okpara, E. S., Hu, W., Yan, C., Wang, Y., Liang, Q., Chiang, J. Y. L., & Han, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158343 · Cited by 206
Metadata
- Authors
- Winston, J. A., & Theriot, C. M.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2019-10-09
- Volume
- 11
- Issue
- 2
- Pages
- 158-171
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- OpenAlex
- W2979675761
- Cited by
- 587
- References
- 116
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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