Cited by 252Gut microbiota and healthNutritional Studies and DietNutrition, Genetics, and Disease

Rethinking healthy eating in light of the gut microbiome

Open access
Armet, Anissa M., Deehan, Edward C., O’Sullivan, Aidan F., Mota, João F., Field, Catherine J., Prado, Carla M., Lucey, Alice J., Walter, Jens·2022·Cell Host & Microbe

Abstract

Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary recommendations are fundamentally important for health promotion. Despite the importance of the human gut microbiota for the physiological effects of diet and chronic disease etiology, national dietary guidelines around the world are just beginning to capitalize on scientific breakthroughs in the microbiome field. In this review, we discuss contemporary nutritional recommendations from a microbiome science perspective, focusing on mechanistic evidence that established host-microbe interactions as mediators of the physiological effects of diet. We apply this knowledge to inform discussions of nutrition controversies, advance innovative dietary strategies, and propose an experimental framework that integrates the microbiome into nutrition research. The congruence of key paradigms in the nutrition and microbiome disciplines validates current recommendations in dietary guidelines, and the systematic incorporation of microbiome science into nutrition research has the potential to further improve and innovate healthy eating.

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Crossref · 10.1016/j.chom.2022.04.016

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  • Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods.

    “Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods. 35-41”

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Authors
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J.
Affiliations
  • University of Alberta (CA)
  • University College Cork (IE)
Corresponding author
Walter, Jens
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2022-06
Volume
30
Issue
6
Pages
764-785
ISSN
1931-3128 (ISSN-L)
OpenAlex
W4282936738
Cited by
252
References
193
Citations by year
2026: 41 · 2025: 80 · 2024: 68 · 2023: 49 · 2022: 14
FWCI
5.50
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pfizer
  • Fresenius Kabi
  • Canadian Institutes of Health Research (PJT-152994)
  • Science Foundation Ireland (19/RP/6853, APC/SFI/12/RC/2273_P2)
  • Alberta Innovates
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
gut microbiota, healthy eating, dietary guidelines, host-microbe interactions, diet-related chronic diseases, dietary recommendations, diet and microbiome
MeSH terms
Gastrointestinal Microbiome, Diet, Healthy, Diet, Humans, Nutritional Status

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