Rethinking healthy eating in light of the gut microbiome
Open accessAbstract
Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary recommendations are fundamentally important for health promotion. Despite the importance of the human gut microbiota for the physiological effects of diet and chronic disease etiology, national dietary guidelines around the world are just beginning to capitalize on scientific breakthroughs in the microbiome field. In this review, we discuss contemporary nutritional recommendations from a microbiome science perspective, focusing on mechanistic evidence that established host-microbe interactions as mediators of the physiological effects of diet. We apply this knowledge to inform discussions of nutrition controversies, advance innovative dietary strategies, and propose an experimental framework that integrates the microbiome into nutrition research. The congruence of key paradigms in the nutrition and microbiome disciplines validates current recommendations in dietary guidelines, and the systematic incorporation of microbiome science into nutrition research has the potential to further improve and innovate healthy eating.
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Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods.
“Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods. 35-41”
From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [39]
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Dubey, I., Nandheeswari, K., Vigneshwaran, G., Rohilla, G., Lalruatmawii, Naxine, P., Jayapradha, P., Rachamalla, M., & Kushwaha, S. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108732 · Cited by 14 · see citing works
Diet–microbial cross–talk underlying increased visceral perception
Palma, G. D., Reed, D. E., & Berčík, P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2166780 · Cited by 13 · see citing works
Fu, J. F., Liang, Z., Chen, Z., Zhou, Y., Xiong, F., Liang, Q., & Gao, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07913 · Cited by 14 · see citing works
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Antioxidants and phytochemicals – a scoping review for Nordic Nutrition Recommendations 2023
Myhrstad, M. C. W., & Wolk, A. (2023) · Food & Nutrition Research · doi:10.29219/fnr.v67.10324 · Cited by 12 · see citing works
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Gut microb-aging and its relevance to frailty aging
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Predicting functions of uncharacterized gene products from microbial communities
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Pro and anti-inflammatory diets as strong epigenetic factors in inflammatory bowel disease
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- Authors
- Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J.
- Affiliations
- University of Alberta (CA)
- University College Cork (IE)
- Corresponding author
- Walter, Jens
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 30
- Issue
- 6
- Pages
- 764-785
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W4282936738
- Semantic Scholar
- fbfaf88746d204711515477f4b1c26eef07a8089
- Cited by
- 252
- References
- 193
- Citations by year
- 2026: 41 · 2025: 80 · 2024: 68 · 2023: 49 · 2022: 14
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Fresenius Kabi
- Canadian Institutes of Health Research (PJT-152994)
- Science Foundation Ireland (19/RP/6853, APC/SFI/12/RC/2273_P2)
- Alberta Innovates
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- gut microbiota, healthy eating, dietary guidelines, host-microbe interactions, diet-related chronic diseases, dietary recommendations, diet and microbiome
- MeSH terms
- Gastrointestinal Microbiome, Diet, Healthy, Diet, Humans, Nutritional Status
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