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Probiotic Lactobacillus reuteri has antifungal effects on oral Candida species in vitro
Open accessAbstract
Background: An alternative approach for managing Candida infections in the oral cavity by modulating the oral microbiota with probiotic bacteria has been proposed.Objective: The aim was to investigate the antifungal potential of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) against six oral Candida species (C. albicans, C. glabrata, C. krusei, C. tropicalis, C. dubliniensis, and C. parapsilosis). Design: The lactobacilli were tested for their ability to co-aggregate with and inhibit the growth of the yeasts assessed by spectrophotometry and the agar overlay inhibition assay. Additionally, the pH was evaluated with microsensors, and the production of hydrogen peroxide (H2O2) by the lactobacilli was verified.Results: Both L. reuteri strains showed co-aggregation abilities with the yeasts. The lactobacilli almost completely inhibited the growth of C. albicans and C. parapsilosis, but did not affect C. krusei. Statistically significant differences in co-aggregation and growth inhibition capacities between the two L. reuteri strains were observed (p<0.001). The pH measurements suggested that C. krusei can resist the acids produced by the lactobacilli.Conclusions: L. reuteri exhibited antifungal properties against five of the six most common oral Candida species. Further, the results reconfirms that the probiotic capacity of L. reuteri is strain specific.
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“however, most studies have only examined intestinal and vaginal probiotic Lactobacillus strains.7, 8, 9 There have been very few studies relating to oral probiotic strains.10”
From Aggregation and adhesion ability of various probiotic strains and Candida species: An in vitro study (2024) · cites this paper as [10]
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Yin, H., Jiang, J., Zhou, Y., Jiang, X., Zhang, C., & Xia, C. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-10977-0
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“In this context, probiotics have emerged as potential biothera-peutic agents with antifungal, antibio fi lm, and immunomodulatory properties (Jørgensen et al., 2017; Hu et al., 2019; Carvalho et al., 2021).”
Interactions between lactobacillus and yeast: A recent update
Chen, Y., Liu, M., Li, M., 岳志云, Mu, Y., Wang, C., Xia, L., Gao, J., Peng, M., Wang, R., et al. (2026) · Food biomacromolecules. · doi:10.1002/fob2.70101
Metadata
- Authors
- Jørgensen, M. R., Kragelund, C., Jensen, P. Ø., Keller, M. K., & Twetman, S.
- Affiliations
- University of Copenhagen (DK)
- Rigshospitalet (DK)
- Corresponding author
- Jørgensen, Mette Rose
- ORCID
- Venue
- Journal of Oral Microbiology
- Publisher
- Informa UK Limited
- Published
- 2017-01-01
- Volume
- 9
- Issue
- 1
- Pages
- 1274582
- ISSN
- 2000-2297 (ISSN-L)
- PMC
- PMC5328390
- OpenAlex
- W2584950134
- Cited by
- 107
- References
- 40
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 21 · 2023: 15 · 2022: 13 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 6 · 2017: 2
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Oral Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tandlægeforeningen ((No number))
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Lactobacillus reuteri, probiotics, antifungal activity, oral candida, Candida albicans, Candida parapsilosis, Candida krusei, co-aggregation, hydrogen peroxide, oral candidiasis, oral microbiota
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