Cited by 107Probiotics and Fermented FoodsOral microbiology and periodontitis researchAntifungal resistance and susceptibility

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Probiotic Lactobacillus reuteri has antifungal effects on oral Candida species in vitro

Open access

Jørgensen, Mette Rose, Kragelund, Camilla, Jensen, Peter Østrup, Keller, Mette Kirstine, Twetman, Svante·2017·Journal of Oral Microbiology

DOI 10.1080/20002297.2016.1274582PMC PMC5328390

Open this paper in CoChat — free account Open PDF

Abstract

Background: An alternative approach for managing Candida infections in the oral cavity by modulating the oral microbiota with probiotic bacteria has been proposed.Objective: The aim was to investigate the antifungal potential of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) against six oral Candida species (C. albicans, C. glabrata, C. krusei, C. tropicalis, C. dubliniensis, and C. parapsilosis). Design: The lactobacilli were tested for their ability to co-aggregate with and inhibit the growth of the yeasts assessed by spectrophotometry and the agar overlay inhibition assay. Additionally, the pH was evaluated with microsensors, and the production of hydrogen peroxide (H2O2) by the lactobacilli was verified.Results: Both L. reuteri strains showed co-aggregation abilities with the yeasts. The lactobacilli almost completely inhibited the growth of C. albicans and C. parapsilosis, but did not affect C. krusei. Statistically significant differences in co-aggregation and growth inhibition capacities between the two L. reuteri strains were observed (p<0.001). The pH measurements suggested that C. krusei can resist the acids produced by the lactobacilli.Conclusions: L. reuteri exhibited antifungal properties against five of the six most common oral Candida species. Further, the results reconfirms that the probiotic capacity of L. reuteri is strain specific.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/20002297.2016.1274582

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Figure 1. Co-aggregation ratio (%) between Candida strains and the Lactobacillus reuteri strains after 4 h of incubation. Mean, error bars indicate standard deviations. *Statistically significant differences (p < 0.05) .L. reuteri DSM 17938: C. tropicalis DSM 7524 showed significantly higher co-aggregation ability compared with C. krusei CCUG 56126, C. dubliniensis 41_3 ZZMK, C. parapsilosis 26 PBS, C. glabrata CBS 863, and C. parapsilosis CCUG 56136. L. reuteri ATCC PTA 5289: C. tropicalis DSM 7524 showed significantly higher co-aggregation ability compared with C. glabrata CBS 863 and C. parapsilosis CCUG 56136. C. krusei CCUG 56126 showed a significantly greater ability to co-aggregate compared with C. parapsilosis CCUG 56136.CC BY · PubMed Central

Figure 2. Microsensor measurement of pH at selected Candida strains grown by the agar overlay technique with L. reuteri ATCC PTA 5289 (103 cfu/mL) in the bottom agar layer. Zero on the vertical axis represents the first reading when the sensors hit either a Candida colony or the agar plates without Candida colonies. For the Candida controls without lactobacilli, data are only presented for C. krusei CCUG 56126.CC BY · PubMed Central

Figure 3. Microsensor measurement of pH at selected Candida strains grown by the agar overlay technique with L. reuteri DSM 17938 (103 cfu/mL) in the bottom agar layer. Zero on the vertical axis represents the first reading when the sensors hit either a Candida colony or the agar plates without Candida colonies. For the Candida controls without lactobacilli, data are only presented for C. krusei CCUG 56126.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184
Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis
Eschenbach, D. A., Davick, P., Williams, B. L., Klebanoff, S. J., Young-Smith, K., Critchlow, C. M., & Holmes, K. K. (1989) · Journal of Clinical Microbiology · doi:10.1128/jcm.27.2.251-256.1989 · Cited by 709
Probiotics: Definition, Sources, Selection, and Uses
Sanders, M. E. (2008) · Clinical Infectious Diseases · doi:10.1086/523341 · Cited by 662
Adhesion and aggregation properties of probiotic and pathogen strains
Collado, M. C., Meriluoto, J., & Salminen, S. (2008) · European Food Research and Technology · doi:10.1007/s00217-007-0632-x · Cited by 603
Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors
Ahola, A. J., Yli‐Knuuttila, H., Suomalainen, T., Poussa, T. A., Ahlström, A., Meurman, J. H., & Korpela, R. (2002) · Archives of Oral Biology · doi:10.1016/s0003-9969(02)00112-7 · Cited by 387
The Fungal Pathogen Candida albicans Autoinduces Hyphal Morphogenesis by Raising Extracellular pH
Vylkova, S., Carman, A. J., Danhof, H. A., Collette, J. R., Zhou, H., & Lorenz, M. C. (2011) · mBio · doi:10.1128/mbio.00055-11 · Cited by 365
Colonization and Immunomodulation by Lactobacillus reuteri ATCC 55730 in the Human Gastrointestinal Tract
Valeur, N., Engel, P. A., Carbajal, N., Connolly, E., & Ladefoged, K. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.2.1176-1181.2004 · Cited by 343
Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria
Cleusix, V., Lacroix, C., Vollenweider, S., Duboux, M., & Blay, G. L. (2007) · BMC Microbiology · doi:10.1186/1471-2180-7-101 · Cited by 271
A characterization of pH-regulated dimorphism in Candida albicans
Buffo, J., Herman, M. A., & Soll, D. R. (1984) · Mycopathologia · doi:10.1007/bf00436698 · Cited by 256
Activity of the plasma membrane H(+)-ATPase and optimal glycolytic flux are required for rapid adaptation and growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid
Holyoak, C. D., Stratford, M., McMullin, Z., Cole, M., Crimmins, K., Brown, A. J. P., & Coote, P. J. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.9.3158-3164.1996 · Cited by 254

Show all 40 references

Research works printed but not linked: 2

Laleman I, 2015, Quintessence Int, 46, 255
Sanders ME., 2008, Clin Infect Dis, 46

Sorted by citations

Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health
Monteagudo-Mera, A., Rastall, R. A., Gibson, G. R., Charalampopoulos, D., & Chatzifragkou, A. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09978-7 · Cited by 743
“For instance, a recent in vitro study reported that two probiotic L. reuteri strains were able to co-aggregate with Candida albicans during biofilm formation creating a hostile environment that inhibited the yeast growth (Jørgensen et al. 2017).”
Background
Role of Lactobacillus reuteri in Human Health and Diseases
Mu, Q., Tavella, V. J., & Luo, X. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00757 · Cited by 744
“Furthermore, some studies suggest that L. reuteri may have antifungal properties as well, where L. reuteri antagonizes, stops the growth of, and eventually kills various species of Candida (Jorgensen et al., 2017).”
Result
Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview
Piqué, N., Berlanga, M., & Miñana-Galbis, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102534 · Cited by 642
“Probiotics have also anti-fungal properties, for example Lactobacillus reuteri against Candida growth [61,67].”
Background
Oral Microbiota and Alzheimer’s Disease: Do All Roads Lead to Rome?
Sureda, A., Daglia, M., Argüelles Castilla, S., Sanadgol, N., Fazel Nabavi, S., Khan, H., Belwal, T., Jeandet, P., Marchese, A., Pistollato, F., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104582 · Cited by 143
Biofilms and vulvovaginal candidiasis
Rodríguez‐Cerdeira, C., Carnero-Gregorio, M., Molares-Vila, A., López-Bárcenas, A., Fabbrocini, G., Bardhi, B., Sinani, A., Sánchez-Blanco, E., Arenas, R., & Hernández‐Castro, R. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.011 · Cited by 159
Probiotics: A Promising Role in Dental Health
Mahasneh, S. A., & Mahasneh, S. A. (2017) · Dentistry Journal · doi:10.3390/dj5040026 · Cited by 112
The role of Lactobacillus species in the control of Candida via biotrophic interactions
Zangl, I., Pap, I.-J., Aspöck, C., & Schüller, C. (2020) · Microbial Cell · doi:10.15698/mic2020.01.702 · Cited by 113
“Therefore, competition for binding sites could be partly influencing proper adhesion of Candida to mucosal surfaces [12].”
Background
The Role of the Oral Microbiome in the Development of Diseases
Kozak, M., & Pawlik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065231 · Cited by 108
A critical appraisal of the effects of probiotics on oral health
Chugh, P., Dutt, R., Sharma, A., Bhagat, N., & Dhar, M. S. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103985 · Cited by 93
The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis
Satiman, E. A. F. E. N., Ahmad, H., Ramzi, A. B., Wahab, R. A., Kaderi, M. A., Himratul-Aznita, W. H., Dashper, S. G., McCullough, M. J., & Arzmi, M. H. (2020) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.13014 · Cited by 71
Antifungal effects of Lactobacillus acidophilus and Lactobacillus plantarum against different oral Candida species isolated from HIV/AIDS patients: an in vitro study
Salari, S., & Ghasemi Nejad Almani, P. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1769386 · Cited by 70
“Then, the co-aggregation percentage was calculated using the following formula [7,15]:”
BackgroundMethod
Effect of probiotics on oral candidiasis: a systematic review and meta-analysis
Mundula, T., Ricci, F., Barbetta, B., Baccini, M., & Amedei, A. (2019) · Nutrients · doi:10.3390/nu11102449 · Cited by 68
“As previously reported, the anti-Candida properties can be explained in different ways, such as (a) through co-aggregation, modification of oral pH, and production of H2O2 [45], (b) through releasing high amounts of lactic acid [47], and (c) through the complete inhibition of fungal biofilms [48,49].”
Background
Oral Candidiasis and Novel Therapeutic Strategies: Antifungals, Phytotherapy, Probiotics, and Photodynamic Therapy
Contaldo, M., Stasio, D. D., Romano, A., Fiori, F., della Vella, F., Rupe, C., Lajolo, C., Petruzzi, M., Serpico, R., & Lucchese, A. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220418104042 · Cited by 75
Action mechanisms of probiotics on Candida spp. and candidiasis prevention: an update
Ribeiro, F. D. C., Rossoni, R. D., de Barros, P. P., dos Santos, J. D., Fugisaki, L. R. D. O., Leão, M. V. P., & Junqueira, J. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14511 · Cited by 65
Oral microbiome in human health and diseases
Tian, S., Ding, T., & Li, H. (2024) · mLife · doi:10.1002/mlf2.12136 · Cited by 65
“For example, Lactobacillus reuteri can be combined with Candida species to decrease pathogenic oral microorganisms, improve dental caries, and maintain oral health 161 .”
Background
Citric acid enhances clean recycling of Chinese cabbage waste by anaerobic fermentation
Li, J., Meng, Q., Xing, J., Wang, C., Song, C., Ma, D., & Shan, A. (2022) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2022.131366 · Cited by 54
Revisiting the intestinal microbiome and its role in Diarrhea and constipation
Iancu, M. A., Profir, M., Roşu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023) · Microorganisms · doi:10.3390/microorganisms11092177 · Cited by 53
Vulvovaginal candidiasis and current perspectives: new risk factors and laboratory diagnosis by using MALDI TOF for identifying species in primary infection and recurrence
Pereira, L. C., Correia, A. F., da Silva, Z. D. L., Resende, C. N., Brandão, F., Almeida, R. M., & Nóbrega, Y. K. D. M. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-021-04199-1 · Cited by 55
Consumption of Lactobacillus reuteri‐containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial
Schlagenhauf, U., Rehder, J., Gelbrich, G., & Jockel‐Schneider, Y. (2020) · Journal of Periodontology · doi:10.1002/jper.19-0393 · Cited by 52
Application of probiotics in candidiasis management
Andrade, J. C., Kumar, S., Kumar, A., Černáková, L., & Rodrigues, C. F. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1926905 · Cited by 43
Aggregation and adhesion ability of various probiotic strains and Candida species: An in vitro study
Chantanawilas, P., Pahumunto, N., & Teanpaisan, R. (2024) · Journal of Dental Sciences · doi:10.1016/j.jds.2024.03.016 · Cited by 46
Antifungal activities against Candida albicans, of cell-free supernatants obtained from probiotic Pediococcus acidilactici HW01
Kim, H., & Kang, S. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.01.006 · Cited by 40
Probiotics—A complete oral healthcare package
Mishra, S., Rath, S., & Mohanty, N. (2020) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2020.08.005 · Cited by 37
Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients
Keller, M. K., & Kragelund, C. (2018) · Oral Diseases · doi:10.1111/odi.12858 · Cited by 36
Pathophysiological microenvironments in oral candidiasis
Jørgensen, M. R. (2024) · Apmis · doi:10.1111/apm.13412 · Cited by 42
An assessment of the aggregation and probiotic characteristics of Lactobacillus species isolated from native (desi) chicken gut
Aziz, G., Fakhar, H., Rahman, S. U., Tariq, M., & Zaidi, A. (2019) · The Journal of Applied Poultry Research · doi:10.3382/japr/pfz042 · Cited by 36
Orodispersible Film Loaded with Enterococcus faecium CRL183 Presents Anti-Candida albicans Biofilm Activity In Vitro
Lordello, V. B., Meneguin, A. B., de Annunzio, S. R., Taranto, M. P., Chorilli, M., Fontana, C. R., & Cavallini, D. C. U. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070998 · Cited by 35
“This acidification in the environment could have promoted the yeast cell energy exhaustion, inhibiting its multiplication and leading to cell death [5].”
Background
Co‐extrusion and extrusion microencapsulation: Effect on microencapsulation efficiency, survivability through gastrointestinal digestion and storage
How, Y. H., Lai, K., Pui, L. P., & In, L. L. A. (2022) · Journal of Food Process Engineering · doi:10.1111/jfpe.13985 · Cited by 32
Reproductive Tract Infections in Dairy Cows: Can Probiotics Curb Down the Incidence Rate?
Rosales, E. B., & Ametaj, B. N. (2021) · Dairy · doi:10.3390/dairy2010004 · Cited by 34
“A study by [179] reported that two probiotic strains of L.”
Background
Influence of culture conditions on co-aggregation of probiotic yeast Saccharomyces boulardii with Candida spp. and their auto-aggregation
Tomičić, R., Tomičić, Z., & Raspor, P. (2022) · Folia Microbiologica · doi:10.1007/s12223-022-00956-7 · Cited by 29
The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections
Boahen, A., Than, L. T. L., Loke, Y.-L., & Chew, S. Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.787119 · Cited by 34
The oral microbiome in oral lichen planus during a 1‐year randomized clinical trial
Kragelund, C., & Keller, M. K. (2018) · Oral Diseases · doi:10.1111/odi.12961 · Cited by 27
The Impact of Lactobacillus reuteri on Oral and Systemic Health: A Comprehensive Review of Recent Research
Liu, Z., Cao, Q., Wang, W., Wang, B., Yang, Y., Xian, C. J., Li, T., & Zhai, Y. (2024) · Microorganisms · doi:10.3390/microorganisms13010045 · Cited by 23
Evaluation of the Role of Probiotics As a New Strategy to Eliminate Microbial Toxins: A Review
Ghadaksaz, A., Nodoushan, S. M., Sedighian, H., Behzadi, E., & Fooladi, A. A. I. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09893-2 · Cited by 20
Probiotics for Oral Candidiasis: Critical Appraisal of the Evidence and a Path Forward
Archambault, L. S., & Dongari‐Bagtzoglou, A. I. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.880746 · Cited by 20
Influence of the use of complete denture adhesives on microbial adhesion and biofilm formation by single- and mixed-species
de Oliveira, N. M., Marín, D. O. M., Leite, A. R. P., Pero, A. C., Klein, M. I., & Compagnoni, M. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203951 · Cited by 22
Strain-Specific Benefits of Bacillus Probiotics in Hybrid Grouper: Growth Enhancement, Metabolic Health, Immune Modulation, and Vibrio harveyi Resistance
Han, C., Song, S., Cui, C., Cai, Y., Zhou, Y., Wang, J., Bei, W., Zhang, D., Guo, W., & Wang, S. (2024) · Animals · doi:10.3390/ani14071062 · Cited by 19
Limosilactobacillus reuteri inhibits the acid tolerance response in oral bacteria
Boisen, G., Prgomet, Z., Enggren, G., Dahl, H., Mkadmi, C., & Davies, J. R. (2023) · Biofilm · doi:10.1016/j.bioflm.2023.100136 · Cited by 18
“Supernatants from L. reuteri ATCC PTA5289 have been shown to inhibit growth of S. mutans, possibly through production of H2O2 [37].”
BackgroundInfluential
Use of Probiotics for Oral Candidiasis: State of the Art and Perspective. A Further Step Toward Personalized Medicine?
Contaldo, M. (2023) · Frontiers in Bioscience-Elite · doi:10.31083/j.fbe1501006 · Cited by 19
“Jørgensen (2017) [78] in vitro on fungal cultures L.”
Evaluating the Probiotic Potential of Lactic Acid Bacteria Implicated in Natural Fermentation of Table Olives, cv. Cobrançosa
Coimbra-Gomes, J., Reis, P. J. M., Tavares, T. G., Faria, M. Â., Malcata, F. X., & Macedo, Â. C. (2023) · Molecules · doi:10.3390/molecules28083285 · Cited by 17
Modulating effects of heat-killed and live Limosilactobacillus reuteri PSC102 on the immune response and gut microbiota of cyclophosphamide-treated rats
Ali, M. S., Lee, E., Quah, Y., Sayem, S. A. J., Abbas, M. A., Suk, K., Lee, S., & Park, S. (2024) · Veterinary Quarterly · doi:10.1080/01652176.2024.2344765 · Cited by 17
Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair
Li, H., Zhou, J., Zhou, Y., Dao, J., Wei, D., & Wang, Y. (2024) · Journal of Polymer Science · doi:10.1002/pol.20240302 · Cited by 16
Limosilactobacillus reuteri AJCR4: A Potential Probiotic in the Fight Against Oral Candida spp. Biofilms
Rajão, A., Silva, J. P. N., Almeida-Nunes, D. L., Rompante, P., Rodrigues, C. F., & Andrade, J. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020638 · Cited by 17
“To evaluate both catalase and proteinase k effects, the pH of the CFS was first adjusted to 7.0 using 5 M NaOH to neutralize acidity.”
Influential
Gut Mycobiome and Asthma
Kanj, A., & Skalski, J. H. (2024) · Journal of Fungi · doi:10.3390/jof10030192 · Cited by 15
“…and other Candida species that are in turn associated with airway inflammation when expanded in the gut [17,42,43]. known for its antifungal effects, particularly against P. kudriavzevii and other Candida species that are associated with airway inflammation when expanded in the gut [17,42,43].”
Background
Antimycotic prophylaxis with multispecies probiotics against oral candidiasis in new complete denture wearers: A randomized clinical trial
Elsayes, S. A., EL-Attar, M. S., Elhadary, A., Aboulela, A., Essawy, M. M., & Soliman, I. S. (2024) · Journal of Prosthetic Dentistry · doi:10.1016/j.prosdent.2024.05.018 · Cited by 14
Lactobacillus rhamnosus strains of oral and vaginal origin show strong antifungal activity in vitro
Jørgensen, M. R., Rikvold, P. D., Lichtenberg, M., Jensen, P. Ø., Kragelund, C., & Twetman, S. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1832832 · Cited by 15
“reuteri strains (ATCC PTA 5289 and DSM 17938) [9].”
BackgroundMethodResultInfluential
Use of Limosilactobacillus reuteri DSM 17938 in paediatric gastrointestinal disorders: an updated review
Dargenio, V. N., Cristofori, F., Dargenio, C., Giordano, P., Indrio, F., Celano, G., & Francavilla, R. (2022) · Beneficial Microbes · doi:10.3920/bm2021.0151 · Cited by 15
Microbiome-mediated regulation of anti-fungal immunity
Zelante, T., Costantini, C., & Romani, L. R. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.05.002 · Cited by 14
Hosein SAFARI http://orcid.org/0000-0002-4687-9685 Setareh SHAHNAZARI http://orcid.org/0000-0002-4687-9685 Maysam MARD-SOLTANI http://orcid.org/0000-0002-9473-2901 Somayeh TAVAKOLI http://orcid.org/0000-0002-3672-4639 02 11 2019 368 374 10.3906/sag-1807-20 http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=sag-1807-20 Anticandidal activities of lactic acid bacteria isolated from the vagina
Er, S., Tosun, A. İ., & Arik, G. (2019) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1709-143 · Cited by 12
“These microorganisms in the vagina can cause infections in certain conditions (22).”
Background
Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation
Chantanawilas, P., Pahumunto, N., Thananimit, S., & Teanpaisan, R. (2024) · Current Microbiology · doi:10.1007/s00284-024-03800-y · Cited by 12
“Certain probiotic Lactobacillus strains and their derived postbiotics could exhibit promising anticandidal activity [11], and it was reported that C. albicans were more susceptible compared to NAC strains [12, 13].”
Challenges and solutions in managing dental problems in children with autism
Al‐Beltagi, M., Zahrani, A. A. A., Mani, B. S., Hantash, E. M., Saeed, N. K., Bediwy, A. S., & Elbeltagi, R. M. (2025) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v14.i3.106778 · Cited by 19
Probiotics for Human Health
Savitri, & Lata, P. (2020) · Microorganisms for sustainability · doi:10.1007/978-981-15-6795-7_8 · Cited by 11
Fifteen Years of Probiotic Therapy in the Dental Context: What Has Been Achieved?
Twetman, S., Jørgensen, M. R., & Keller, M. K. (2017) · Journal of the California Dental Association · doi:10.1080/19424396.2017.12222503 · Cited by 11
The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota composition in individuals with stage III–IV periodontitis: a randomized controlled trial
Huo, P., Deng, L., Lu, J., Kan, P., Jing, R., & Luo, L.-J. (2025) · BMC Oral Health · doi:10.1186/s12903-025-06084-1 · Cited by 9
“For example, Jørgensen et al. [56] reported that L. reuteri almost completely inhibited Candida albicans and Candida smoothii growth in a co-culture.”
Influence of cell-free extracts of Bifidobacterium bifidum and Lactobacillus reuteri on proliferation and biofilm formation by Escherichia coli and Pseudomonas aeruginosa
Knysh, O. V., Isayenko, O. Y., Voyda, Y. V., Kizimenko, O. O., & Babych, Y. M. (2019) · Regulatory Mechanisms in Biosystems · doi:10.15421/021938 · Cited by 9
Efficacy of probiotics for oral candidiasis management: a systematic review
Li, P., Yu, X., Chen, C., Zhao, Z., Lu, X., & Fan, Y. (2025) · BMC Oral Health · doi:10.1186/s12903-025-06468-3 · Cited by 10
Non-Pharmacological Interventions to Prevent Oropharyngeal Candidiasis in Patients Using Inhaled Corticosteroids: A Narrative Review
Patiño, L. A., & Benavides-Córdoba, V. (2025) · Healthcare · doi:10.3390/healthcare13141718 · Cited by 10
ANTIBACTERIAL ACTIVITY AND IDENTIFICATION OF PRODUCED REUTERIN FROM LOCAL Lactobacillus reuteri LBIQ1 ISOLATE
Niamah, A. K., Mohammed, A. A., & Alhelf, N. A. (2023) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.55251/jmbfs.4701 · Cited by 8
Limosilactobacillus reuteri as sustainable biological control agent against toxigenic Fusarium verticillioides
Hirozawa, M. T., Ono, M. A., Suguiura, I. M. D. S., García, S., Bordini, J. G., Amador, I. R., Hirooka, E. Y., & Ono, E. Y. S. (2023) · Brazilian Journal of Microbiology · doi:10.1007/s42770-023-01081-4 · Cited by 8
“Some of its metabolites, such as reuterin (3-hydroxypropionaldehyde), have been reported to inhibit Gram-positive and Gram-negative bacteria, fungi, and protozoa, including food spoilage microorganisms and pathogens [38, 48].”
Background
Short-Term Probiotic Administration Increases Fecal-Anti Candida Activity in Healthy Subjects
Angelis, M. D., Scagnolari, C., Oliva, A., Cavallari, E. N., Celani, L., Santinelli, L., Innocenti, G. P., Borrazzo, C., Ceccarelli, G., Vullo, V., et al. (2019) · Microorganisms · doi:10.3390/microorganisms7060162 · Cited by 8
Probiotic Interventions for Oral Health
Twetman, S., & Jørgensen, M. R. (2021) · Springer eBooks · doi:10.1007/978-981-33-6236-9_11 · Cited by 8
Unraveling brain aging through the lens of oral microbiota
Hu, Q., Wang, S., Zhang, W., Qu, J. T., & Liu, G. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01761 · Cited by 8
Synergistic Inhibition of Synbiotic Cultures among Lactobacilli and Plant Extracts against Vaginal Discharge Causing Candida albicans
Sookkhee, S., Khamnoi, P., Sastraruji, T., Boonkum, S., Wikan, N., & Nimlamool, W. (2024) · Nutrients · doi:10.3390/nu16091372 · Cited by 7
Genetic diversity of Lactobacillus spp. isolates from oral cavity and their probiotic and antimicrobial properties
Azizian, K., Osquee, H. O., Pourlak, T., Hosseinpour, R., Asgharzadeh, M., Ganvarov, K., & Kafil, H. S. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101231 · Cited by 7
Oral Biofilm Composition, Dissemination to Keratinocytes, and Inflammatory Attenuation Depend on Probiotic and Synbiotic Strain Specificity
Holm, W. V., Zayed, N., Lauwens, K., Saghi, M., Axelsson, J., Aktan, M. K., Braem, A., Simoens, K., Vanbrabant, L., Proost, P., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10253-z · Cited by 6
“Despite the fact that these mechanisms are unknown for the current strains, lactobacilli can produce a wide variety of antimicrobials such as reutericyclin [41], diverse bacteriocins [42, 43], hydrogen peroxide [44, 45], and lactic acid [46].”
In Vitro Inhibitory Effects and Co-Aggregation Activity of Lactobacilli on Candida albicans
Yocheva, L. D., Tserovska, L., Danguleva, A., Todorova, T., Zhelezova, G., Karaivanova, E., & Georgieva, R. (2024) · Microbiology Research · doi:10.3390/microbiolres15030104 · Cited by 6
“Here, species and strain specific co-aggregation activity were registered with C. albicans in accordance with other studies [34,39].”
Result
Evaluation of the antifungal activity of Lactobacillus reuteri against Candida species
bakhshi, M., Salari, S., Almani, P. G. N., & Afshari, S. A. K. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101369 · Cited by 6
Harnessing Probiotics to Combat Candidiasis: Mechanisms, Evidence, and Future Directions
Wright, E., Valand, N., & Girija, U. V. (2025) · Journal of Fungi · doi:10.3390/jof11110779 · Cited by 5
“L. reuteri is also noted to produce reuterin, a broad-spectrum antimicrobial that can inhibit bacteria, protozoa, and fungi, such as Candida [125].”
Antagonistic activity of Lactiplantibacillus plantarum 6.2 extracted from cocoa fermentation and its supernatant on Gardnerella vaginalis
Ramos, L. P., de Almeida, M. E., Freire, H. P. S., Pessoa, W. F. B., Rezende, R. P., & Romano, C. C. (2022) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202220210731 · Cited by 5
Mechanisms of action of Lactobacillus spp. in the treatment of oral candidiasis
Ferreira, R. L. P. S., Nova, B. G. V., do Carmo, M. S., & Abreu, A. G. (2024) · Brazilian Journal of Biology · doi:10.1590/1519-6984.282609 · Cited by 5
Cinnamaldehyde and α-terpineol inhibit the growth of planktonic cultures of Candida albicans and non albicans
Martorano-Fernandes, L., Lacerda, M. C., Cavalcanti, Y. W., & de Almeida, L. D. F. D. (2021) · Research Society and Development · doi:10.33448/rsd-v10i10.19027 · Cited by 4
Overview of oral health status and associated risk factors in maritime settings: An updated systematic review
Nguyen, T. P. A., Gautam, S., Mahato, S., Jensen, O. C., Roudsari, A. H., & Baygi, F. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293118 · Cited by 4
Probiotics and Oral Complications of Antineoplastic Therapy in Head and Neck Cancer: A Systematic Review and Meta-Analysis
Pereira-Riveros, T., Salas, E. J., López‐López, J., Saka‐Herrán, C., Galiana, I. L., & Vinuesa, T. (2025) · Dentistry Journal · doi:10.3390/dj13060254 · Cited by 4
“Jørgensen et al. (2017) reported its inhibitory effects against C. albicans , C. dubliniensis , C. tropicalis , C. parapsilosis , and C. glabrata , although not C. krusei [42].”
Antifungal Effect of Probiotic Lactobacillus casei on Drug-Resistant Oral Candida albicans Isolated from Patients with Hematological Malignancy: an in vitro Study.
Reyhani, M. F., Ghasemi, N., Milani, A. S., & Asl, M. A. (2023) · PubMed Central · doi:10.30476/dentjods.2022.94792.1812 · Cited by 4
Inhibitory effect of isolated Lactobacillus from oral cavity against bacterial Pathogens and its effect on health promotion
Azizian, K., Taghizadeh, S., Hosseinpour, R., Tanomand, A., Sheikhsaran, E., Alizadeh, N., Naghili, B., & Kafil, H. S. (2019) · Ars Pharmaceutica (Internet) · doi:10.30827/ars.v60i1.7943 · Cited by 4
The effect of probiotic Lactobacillus rhamnosus GG on Candida albicans and Candida tropicalis biofilm formation: A preliminary study
Fuad, A. S. M., Mazlan, W. N. A. W., Wahab, R. A., Nasruddin, N. S., & Arzmi, M. H. (2023) · International Journal of Orofacial and Health Sciences · doi:10.31436/ijohs.v4i2.204 · Cited by 3
3L, Three-Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats
Yue, S., Zhang, Z., Bian, F., Zhang, Y., Gao, C., Zhu, Y., Li, J., & Picimbon, J. (2023) · Microbiology Research · doi:10.3390/microbiolres14030059 · Cited by 2
Does Probiotic Intake Enhance the Efficacy of Oral Fungal Infection Treatment?
Klosek, S. K., Szymczak-Paluch, M., Bernaś, A. A., & Gawlak-Socka, S. (2026) · Nutrients · doi:10.3390/nu18091433 · Cited by 2
“Furthermore, Lactobacillus reuteri strains DSM 17938 and ATCC PTA 5289 demonstrated antifungal activity against several Candida species by reducing fungal growth and showing co-aggregation with five of the six species investigated [21].”
PROBIOTIC PROPERTIES OF LACTOBACILLUS REUTERI (L. REUTERI) STRAINS
Novikova, V. P., & Магомедова, Д. М. (2023) · Children s medicine of the North-West · doi:10.56871/cmn-w.2023.75.34.002 · Cited by 3
Probiotic Enterococcus faecium CRL 183 Inhibits Candida albicans Biofilm In Vitro
Lordello, V. B., de Annunzio, S. R., da Silva, E. P., Taranto, M. P., Fontana, C. R., & Cavallini, D. C. U. (2024) · Microbiology Research · doi:10.3390/microbiolres15040141 · Cited by 2
Industrial Requirements and Other Techno-functional Traits of Probiotics
Rajivgandhi, G. N., Vimala, R. T. V., Ramachandran, G., & Manoharan, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822909-5.00030-7 · Cited by 3
Traditional Processing and Quality Assessment of a Fermented Date-Based Beverage Made from Northern Chad
Daoudou, B., Bayoï, J. R., Garga, Y., Djouldé, D. R., & Tatsadjieu, L. (2022) · American Journal of Food Technology · doi:10.3923/ajft.2022.10.16 · Cited by 1
Surface Properties and Potential Immunomodulatory Effects of Candidate Probiotic Lactobacilli for Gastrointestinal Applications
Duche, R. T., Kaur, J., Singh, A., Sangwan, V., Sihag, M. K., Nwagu, T. N., Ezeogu, L. I., & Panwar, H. (2025) · Advanced Gut & Microbiome Research · doi:10.1155/agm3/7768975 · Cited by 1
Genomic and phenotypic characterization of two novel human-derived Limosilactobacillus reuteri strains with unique probiotic traits
Yang, L., Zhan, H., Wu, X., Wang, A., Zou, Y., Li, J., Lu, Y., & Ge, Z. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1723084 · Cited by 1
Probiotics for oral health and disease treatment
Meurman, J. H., & Stamatova, I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89908-6.00008-x · Cited by 1
Benefits and safety of probiotics in gastrointestinal diseases
Profir, M., Roşu, O. A., Ionescu, R. F., Pavelescu, L. A., & Creţoiu, S. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-824472-2.00011-7 · Cited by 1
Microbiome in Defence Against Pathogens
Ramanathan, J. (2024) · Springer eBooks · doi:10.1007/978-3-031-70088-0_16 · Cited by 2
Probiotic Enterococcus durans Interference with Oral Candida albicans Adhesion: An in vitro Study
Rashidi, M., Ahmadi, A., Ramazanzadeh, R., Noori, B., & Shafiee, F. (2020) · Journal of Advances in Medical and Biomedical Research · doi:10.30699/jambs.28.130.291 · Cited by 1
“reuteri produced lactic acid and organic acid decreased the pH of agar culture media and inhibited hyphal morphogenesis induction in Candida species (1).”
BackgroundInfluential
Rôle de GroEL, une protéine sécrétée par les probiotiques, dans la prévention de l'inflammation du côlon
Dias, A. M. M. (2018) · theses.fr (ABES) · doi:10.70675/d23527b7z823fz490fzafeez21e0de6d2406 · Cited by 1
Einsatz von Probiotika in der Therapie parodontaler Erkrankungen
Jockel‐Schneider, Y., Schlagenhauf, U., & Rehder, J. (2021) · ZWR - Das Deutsche Zahnärzteblatt · doi:10.1055/a-1473-0008
Pre- och probiotika för profylax och behandling av orala sjukdomar
Twetman, S., & Jørgensen, M. R. (2022) · Aktuel nordisk odontologi · doi:10.18261/issn.2058-7538-2022-01-07
3L, three-Lactobacilli on recovering of microbiome and immune-damage by cyclophosphamide chemotherapyPreprint
Yue, S., Zhang, Z., Bian, F., Zhang, Y., Gao, C., Zhu, Y., Li, J., & Picimbon, J. (2022) · Research Square · doi:10.21203/rs.3.rs-2113752/v1
3L, three-Lactobacilli on recovering of microbiome and immune-damage by cyclophosphamide chemotherapy —A pilot experiment—Preprint
Yue, S., Zhang, Z., Bian, F., Zhang, Y., Gao, C., Zhu, Y., Li, J., & Picimbon, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2423168/v1
3L, three-Lactobacilli on recovering of microbiome and immune-damage by cyclophosphamide chemotherapy —A pilot experiment in rats—Preprint
Yue, S., Zhang, Z., Bian, F., Zhang, Y., Gao, C., Zhu, Y., Li, J., & Picimbon, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2451339/v1
Lactobacilli and Klebsiella: Two Opposites in the Fight for Human Health
Shaposhnikov, L. A., Tishkov, V. I., & POMETUN, A. A. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924140050
Oropharyngeal candidiasis — interdisciplinary aspects of childhood medicine
Mokia-Serbina, S. O., & Фесенко, В. І. (2024) · CHILD`S HEALTH · doi:10.22141/2224-0551.19.4.2024.1711
Sobrenadante de Lactobacillus spp. aislados de secreción vaginal y su actividad antagónica sobre especies de Candida
Chinchay, G., Guerra, F., Pérez, G., Coronel, J., & la Cruz, A. D. (2024) · Revista Científica Dékamu Agropec · doi:10.55996/dekamuagropec.v5i2.263
Uso de probióticos para el control de enfermedades orales.
Córdova, S., Bravo, P. P. O., Andrade, C., & Criollo, P. F. S. (2025) · Revista de la Asociación Dental Mexicana · doi:10.35366/119883
Application of probiotics in treatment and healthcare
Waseem, M., Javed, M. R., Saleem, M., Manzoor, M. F., Nayik, G. A., & Jagdale, Y. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27594-4.00013-9
Revisión sistemática exploratoria: Utilidad de los probióticos en la odontología pediátrica preventiva
Centeno, J. E. O., Sotelo, R. N. G., Centeno, M. O., & Castillo, V. M. (2025) · Gaceta Médica Boliviana · doi:10.47993/gmb.v48i2.1012

Authors: Jørgensen, M. R., Kragelund, C., Jensen, P. Ø., Keller, M. K., & Twetman, S.
Affiliations: University of Copenhagen (DK)
Rigshospitalet (DK)
Corresponding author: Jørgensen, Mette Rose
ORCID: Jørgensen, Mette Rose
Kragelund, Camilla
Jensen, Peter Østrup
Keller, Mette Kirstine
Twetman, Svante
Venue: Journal of Oral Microbiology
Publisher: Informa UK Limited
Published: 2017-01-01
Volume: 9
Issue: 1
Pages: 1274582
ISSN: 2000-2297 (ISSN-L)
DOI: 10.1080/20002297.2016.1274582
PMC: PMC5328390
OpenAlex: W2584950134
Cited by: 107
References: 40
Citations by year: 2026: 7 · 2025: 12 · 2024: 21 · 2023: 15 · 2022: 13 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 6 · 2017: 2
FWCI: 8.93
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Oral Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Tandlægeforeningen ((No number))
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: Lactobacillus reuteri, probiotics, antifungal activity, oral candida, Candida albicans, Candida parapsilosis, Candida krusei, co-aggregation, hydrogen peroxide, oral candidiasis, oral microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Probiotic Lactobacillus reuteri has antifungal effects on oral Candida species in vitro

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks