The DOI matches its Crossref record, with a small difference in title or year; 55 of the 55 references it cites were found in a registry or an index.
Fast-cycling Rho GTPases
Abstract
The Rho GTPases were discovered more than 30 years ago, and they were for a long time considered to follow simple cycling between GDP-bound and GTP-bound conformations, as for the Ras subfamily of small GTPases. The Rho GTPases consist of 20 members, but at least 10 of these do not follow this classical GTPase cycle. Thus, based on their kinetic properties, these Rho GTPases can instead be classified as atypical. Some of these atypical Rho GTPases do not hydrolyze GTP, and some have significantly increased intrinsic GDP/GTP exchange activity. This review focuses on this latter category of atypical Rho GTPases, the so-called 'fast-cycling' Rho GTPases. The different members of these fast-cycling atypical Rho GTPases are described in more detail here, along with their potential regulatory mechanisms. Finally, some insights are provided into the involvement of the atypical Rho GTPases in human pathologies.
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“By contrast, the GTPase defective atypical Rho-family members, including Rnd1, Rnd2, Rnd3, RhoBTB1, RhoBTB2 and RhoH, do not possess the conserved Gly12, Ala59 and Gln61 compared with Cdc42 (Table 3) [4,13].”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [13]
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“It also contains a shorter Rho insert region that is more similar to classical Rho-family proteins but is GTPase defective because conserved residues corresponding to Gly12, Ala59 and Gln61 (Ras numbering) are absent (Table 3).”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [13]
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Cited by
Müller, P. M., Rademacher, J., Bagshaw, R. D., Wortmann, C., Barth, C., van Unen, J., Alp, K. M., Giudice, G., Eccles, R. L., Heinrich, L. E., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0488-x · Cited by 253
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The Role of RhoH in TCR Signalling and Its Involvement in Diseases
Ahmad Mokhtar, A. M., Hashim, I. F., Mohd Zaini Makhtar, M., Salikin, N. H., & Amin-Nordin, S. (2021) · Cells · doi:10.3390/cells10040950 · Cited by 25
Metadata
- Authors
- Aspenström, P.
- Affiliations
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg 16, Box 280, SE, Stockholm, Sweden
- Venue
- Small GTPases
- Publisher
- Informa UK Limited
- Published
- 2018-01-29
- Volume
- 11
- Issue
- 4
- Pages
- 248-255
- ISSN
- 2154-1248
- 2154-1256
- Cited by
- 46
- References
- 55
- Language
- en
- Funders
- Swedish cancer society (2014/0644)
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