The DOI matches its Crossref record; 249 of the 249 references it cites were found in a registry or an index.
Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells
Open accessAbstract
It has become evident that tumor-induced immuno-suppressive factors in the tumor microenvironment play a major role in suppressing normal functions of effector T cells. These factors serve as hurdles that limit the therapeutic potential of cancer immunotherapies. This review focuses on illustrating the molecular mechanisms of immunosuppression in the tumor microenvironment, including evasion of T-cell recognition, interference with T-cell trafficking, metabolism, and functions, induction of resistance to T-cell killing, and apoptosis of T cells. A better understanding of these mechanisms may help in the development of strategies to enhance the effectiveness of cancer immunotherapies.
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Cites
2 retracted
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Cited by
TIGIT as an emerging immune checkpoint
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T Cell Dysfunction and Exhaustion in Cancer
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“In addition, NO alone can suppress CD8 T cells by inhibiting the phosphorylation and activation of JAK3 and STAT5 transcription factors, as well as inducing T-cell apoptosis (Wu et al., 2015).”
BackgroundAcquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression
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Cell Therapy: Types, Regulation, and Clinical Benefits
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Metadata
- Authors
- Wu, A. A., Drake, V., Huang, H.-S., Chiu, S., & Zheng, L.
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2015-04
- Volume
- 4
- Issue
- 7
- Pages
- e1016700
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- OpenAlex
- W1587652097
- Cited by
- 271
- References
- 249
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wu, A. A., Drake, V., Huang, H.-S., Chiu, S., & Zheng, L. (2015). Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells. OncoImmunology. https://doi.org/10.1080/2162402x.2015.1016700
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