Priming of neutrophils toward NETosis promotes tumor growth

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works

Novel cell death program leads to neutrophil extracellular traps

Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197 · see citing works

Extracellular DNA traps promote thrombosis

Fuchs, T. A., Brill, A. G., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D. D., Wrobleski, S. K., Wakefield, T. W., Hartwig, J. H., & Wagner, D. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005743107 · Cited by 2,517 · see citing works

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103 · see citing works

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

Wang, Y., Li, M., Stadler, S. C., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,532 · see citing works

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100239 · Cited by 1,495 · see citing works

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

Cools-Lartigue, J., Spicer, J., McDonald, B., Gowing, S., Chow, S., Giannias, B., Bourdeau, F., Kubes, P., & Ferri, L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67484 · Cited by 1,395 · see citing works

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Wong, S. L., Demers, M., Martinod, K., Gallant, M., Wang, Y., Goldfine, A. B., Kahn, C. R., & Wagner, D. D. (2015) · Nature Medicine · doi:10.1038/nm.3887 · Cited by 1,264 · see citing works

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Maßberg, S., Grahl, L., von Bruehl, M., Manukyan, D., Pfeiler, S., Goosmann, C., Brinkmann, V., Lorenz, M., Bidzhekov, K., Khandagale, A. B., et al. (2010) · Nature Medicine · doi:10.1038/nm.2184 · Cited by 1,212 · see citing works

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

Demers, M., Krause, D. S., Schatzberg, D., Martinod, K., Voorhees, J. R., Fuchs, T. A., Scadden, D. T., & Wagner, D. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200419109 · Cited by 883 · see citing works

Thrombosis: tangled up in NETs

Martinod, K., & Wagner, D. D. (2013) · Blood · doi:10.1182/blood-2013-10-463646 · Cited by 875 · see citing works

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Lewis, H. D., Liddle, J., Coote, J., Atkinson, S. J., Barker, M. D., Bax, B. D., Bicker, K. L., Bingham, R. P., Campbell, M. J., Chen, Y. H., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1735 · Cited by 794 · see citing works

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

Metzler, K. D., Fuchs, T. A., Nauseef, W. M., Reumaux, D., Roesler, J., Schulze, I., Wahn, V., Papayannopoulos, V., & Zychlinsky, A. (2010) · Blood · doi:10.1182/blood-2010-06-290171 · Cited by 775 · see citing works

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584 · see citing works

P-selectin promotes neutrophil extracellular trap formation in mice

Etulain, J., Martinod, K., Wong, S. L., Cifuni, S. M., Schattner, M. A., & Wagner, D. D. (2015) · Blood · doi:10.1182/blood-2015-01-624023 · Cited by 557 · see citing works

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

Martinod, K., Demers, M., Fuchs, T. A., Wong, S. L., Brill, A. G., Gallant, M., Hu, J., Wang, Y., & Wagner, D. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301059110 · Cited by 532 · see citing works

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

Carmona‐Rivera, C., Zhao, W., Yalavarthi, S., & Kaplan, M. J. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204837 · Cited by 459 · see citing works

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov, R. V., Fridlender, Z. G., & Granot, Z. (2014) · Cancer Microenvironment · doi:10.1007/s12307-014-0147-5 · Cited by 415 · see citing works

Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition

Keshari, R. S., Jyoti, A., Dubey, M., Kothari, N., Kohli, M., Bogra, J., Barthwal, M. K., & Dikshit, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048111 · Cited by 390 · see citing works

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage

Kisucka, J., Butterfield, C., Duda, D. G., Eichenberger, S. C., Saffaripour, S., Ware, J. L., Ruggeri, Z. M., Jain, R. K., Folkman, J., & Wagner, D. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510412103 · Cited by 360 · see citing works

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

Mishalian, I., Bayuh, R., Levy, L., Zolotarov, L., Michaeli, J., & Fridlender, Z. G. (2013) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1476-9 · Cited by 356 · see citing works

Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis

Shen, M., Hu, P., Donskov, F. N., Wang, G., Liu, Q., & Du, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098259 · Cited by 348 · see citing works

Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system.

el-Hag, A., & Clark, R. A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.7.2406 · Cited by 337 · see citing works

Modulation of neutrophil granulocytes in the tumor microenvironment: Mechanisms and consequences for tumor progression

Dumitru, C. A., Lang, S., & Brandau, S. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.02.005 · Cited by 302 · see citing works

A proposed role for neutrophil extracellular traps in cancer immunoediting

Berger‐Achituv, S., Brinkmann, V., Abed, U. A., Kühn, L. I., Ben‐Ezra, J. M., Elhasid, R., & Zychlinsky, A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00048 · Cited by 288 · see citing works

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis

Wang, S., & Wang, Y. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.07.003 · Cited by 283 · see citing works

NETosis: A New Factor in Tumor Progression and Cancer-Associated Thrombosis

Demers, M., & Wagner, D. D. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1370765 · Cited by 261 · see citing works

Increased PADI4 expression in blood and tissues of patients with malignant tumors

Chang, X., Han, J., Pang, L., Zhao, Y., Yang, Y. L., & Shen, Z. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-40 · Cited by 255 · see citing works

Neutrophil extracellular traps

Demers, M., & Wagner, D. D. (2013) · OncoImmunology · doi:10.4161/onci.22946 · Cited by 234 · see citing works

Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors

Chang, X., & Han, J. (2005) · Molecular Carcinogenesis · doi:10.1002/mc.20169 · Cited by 186 · see citing works

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

Boone, B. A., Orlichenko, L. S., Schapiro, N. E., Loughran, P., Gianfrate, G., Ellis, J. T., Singhi, A. D., Kang, R., Tang, D., Lotze, M. T., et al. (2015) · Cancer Gene Therapy · doi:10.1038/cgt.2015.21 · Cited by 173 · see citing works

Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment

Lu, T., & Gabrilovich, D. I. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2939 · Cited by 143 · see citing works

Increased Levels of Granulocytic Myeloid-Derived Suppressor Cells in Peripheral Blood and Tumour Tissue of Pancreatic Cancer Patients

Khaled, Y. S., Ammori, B. J., & Elkord, E. (2014) · Journal of Immunology Research · doi:10.1155/2014/879897 · Cited by 130 · see citing works

Innate Immune Cells Induce Hemorrhage in Tumors during Thrombocytopenia

Ho‐Tin‐Noé, B., Carbó, C., Demers, M., Cifuni, S. M., Goerge, T., & Wagner, D. D. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090460 · Cited by 94 · see citing works

Role of thrombin as a tumor growth factor

Green, D., & Karpatkin, S. (2010) · Cell Cycle · doi:10.4161/cc.9.4.10729 · Cited by 54 · see citing works

Granulocyte-Colony Stimulating Factor-Producing Pancreatic Adenosquamous Carcinoma Showing Aggressive Clinical Course

Joshita, S., Nakazawa, K., Sugiyama, Y., et al. (2009) · Internal Medicine · doi:10.2169/internalmedicine.48.1900 · Cited by 54 · see citing works

Expression of granulocyte‐colony‐stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens

Morales‐Arias, J., Meyers, P. A., Bolontrade, M. F., et al. (2007) · Cancer · doi:10.1002/cncr.22964 · Cited by 36 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Neutrophil extracellular traps: protagonists of cancer progression?

Erpenbeck, L., & Schön, M. P. (2017) · Oncogene · doi:10.1038/onc.2016.406 · Cited by 199 · see citing works

A novel rapid Neutrophil Extracellular Trap (NET) release mechanism without neutrophil death

Kubes⁎, P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.097

Neutrophil elastase‐deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

Martinod, K., Witsch, T., Farley, K., Gallant, M., Remold‐O'Donnell, E., & Wagner, D. D. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13239 · Cited by 188 · see citing works

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA

Kraaij, T., Kamerling, S. W. A., van Dam, L. S., et al. (2018) · Kidney International · doi:10.1016/j.kint.2018.01.013 · Cited by 96 · see citing works

Evaluation of Circulating Markers of Neutrophil Extracellular Trap (NET) Formation as Risk Factors for Diabetic Retinopathy in a Case-Control Association Study

Park, J. H., Kim, J. E., Gu, J. Y., et al. (2016) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0042-101792 · Cited by 54 · see citing works

[Techniques for detection and role of extracellular neutrophil traps in antimicrobial protection].

Dolgushin, I. I., Shishkova, I. S., Savochkina, A. I., et al. (2010) · PubMed