Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Open accessAbstract
The majority of patients with cancer undergo at least one surgical procedure as part of their treatment. Severe postsurgical infection is associated with adverse oncologic outcomes; however, the mechanisms underlying this phenomenon are unclear. Emerging evidence suggests that neutrophils, which function as the first line of defense during infections, facilitate cancer progression. Neutrophil extracellular traps (NETs) are extracellular neutrophil-derived DNA webs released in response to inflammatory cues that trap and kill invading pathogens. The role of NETs in cancer progression is entirely unknown. We report that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions. In a murine model of infection using cecal ligation and puncture, we demonstrated microvascular NET deposition and consequent trapping of circulating lung carcinoma cells within DNA webs. NET trapping was associated with increased formation of hepatic micrometastases at 48 hours and gross metastatic disease burden at 2 weeks following tumor cell injection. These effects were abrogated by NET inhibition with DNAse or a neutrophil elastase inhibitor. These findings implicate NETs in the process of cancer metastasis in the context of systemic infection and identify NETs as potential therapeutic targets.
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NETs have been directly associated with the initiation and induction of tumor invasion, aiding metastasis.
“recently, through increasing evidence, NETs have been directly associated with the initiation and induction of tumor invasion, aiding metastasis [20, 33–36].”
NETs that form intravascularly in response to infection can promote extravasation of disseminated cancer cells.
“NETs that form intravascularly in response to infection can promote extravasation of disseminated cancer cells (5).”
From Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) · cites this paper as [5]
Digesting bacterially induced NETs with systemically administered DNase I can reduce experimental metastasis in a mouse model of metastatic lung cancer, but the effects are relatively modest.
“Digesting bacterially induced NETs with systemically administered DNase I can reduce experimental metastasis in a mouse model of metastatic lung cancer, but the effects are relatively modest (5).”
From Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) · cites this paper as [5]
The DNA mesh can trap circulating cancer cells at the site of dissemination.
“The DNA mesh can trap circulating cancer cells at the site of dissemination (5).”
From Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) · cites this paper as [5]
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- Authors
- Cools-Lartigue, J., Spicer, J., McDonald, B., Gowing, S., Chow, S., Giannias, B., Bourdeau, F., Kubes, P., & Ferri, L.
- Affiliations
- McGill University (CA)
- University of Calgary (CA)
- Corresponding author
- Ferri, Lorenzo
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2013-07-01
- Volume
- 123
- Issue
- 8
- Pages
- 3446-3458
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3726160
- OpenAlex
- W2140995313
- Cited by
- 1,395
- References
- 78
- Citations by year
- 2026: 110 · 2025: 125 · 2024: 126 · 2023: 141 · 2022: 152 · 2021: 177 · 2020: 153 · 2019: 94 · 2018: 84 · 2017: 74 · 2016: 77 · 2015: 43 · 2014: 34 · 2013: 2
- FWCI
- 28.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- National Eye Institute
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- neutrophil extracellular traps, circulating tumor cells, metastasis, systemic infection, neutrophils, lung cancer, cecal ligation and puncture, neutrophil elastase, DNase, postoperative infection
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