Adenoviral vector-based strategies against infectious disease and cancer
Open accessAbstract
Adenoviral vectors are widely employed against infectious diseases or cancers, as they can elicit specific antibody responses and T cell responses when they are armed with foreign genes as vaccine carriers, and induce apoptosis of the cancer cells when they are genetically modified for cancer therapy. In this review, we summarize the biological characteristics of adenovirus (Ad) and the latest development of Ad vector-based strategies for the prevention and control of emerging infectious diseases or cancers. Strategies to circumvent the pre-existing neutralizing antibodies which dampen the immunogenicity of Ad-based vaccines are also discussed.
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The recombinant adenovirus-vectored vaccine is easily manipulated for genetic modification and capable of inducing potent antigen-specific immune responses.
“The recombinant adenovirus-vectored vaccine is easily manipulated for genetic modification and capable of inducing potent antigen-specific immune responses”
From Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2 (2020) · cites this paper as Zhang and Zhou, 2016
Neutralizing antibody against the carrier vector virus is still a challenge for adenovirus-vectored vaccines.
“but the neutralizing antibody against the carrier vector virus is still a challenge (Zhang and Zhou, 2016).”
From Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2 (2020) · cites this paper as Zhang and Zhou, 2016
Adenoviral vector vaccines have been extensively studied for safety, and adenoviral vector-based therapeutic drugs are used in clinical practice.
“The safety of adenoviral vector vaccines has been extensively studied, and adenoviral vector-based therapeutic drugs are used in clinical practice.5, 6, 7”
The CDC recommended biosafety level (in vivo) for AAV is ABSL-1.
“ABSL-1”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [76]
The NIH risk group for AAV is 1 and the recommended in vitro biosafety level is BSL-1.
“1 BSL-1 b”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [76]
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- Authors
- Zhang, C., & Zhou, D.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhou, Dongming
- Venue
- Human Vaccines & Immunotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2016-04-22
- Volume
- 12
- Issue
- 8
- Pages
- 2064-2074
- ISSN
- 2164-5515 (ISSN-L)
- 2164-554X
- PMC
- PMC4994731
- OpenAlex
- W2338153609
- Cited by
- 110
- References
- 142
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 18 · 2021: 27 · 2020: 21 · 2019: 13 · 2018: 6 · 2017: 6 · 2016: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Human Vaccines & Immunotherapeutics (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- adenoviral vector, adenovirus, gene therapy vectors, adenovirus vector vaccine, emerging infectious diseases, neutralizing antibodies, immunogenicity, T cell response, antibody response, apoptosis induction
- MeSH terms
- Adenoviridae, Drug Carriers, Genetic Vectors, Humans, Neoplasms, Disease Transmission, Infectious, Oncolytic Virotherapy
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