Cited by 110Virus-based gene therapy researchImmunotherapy and Immune ResponsesSARS-CoV-2 and COVID-19 Research

Adenoviral vector-based strategies against infectious disease and cancer

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Zhang, Chao, Zhou, Dongming·2016·Human Vaccines & Immunotherapeutics

Abstract

Adenoviral vectors are widely employed against infectious diseases or cancers, as they can elicit specific antibody responses and T cell responses when they are armed with foreign genes as vaccine carriers, and induce apoptosis of the cancer cells when they are genetically modified for cancer therapy. In this review, we summarize the biological characteristics of adenovirus (Ad) and the latest development of Ad vector-based strategies for the prevention and control of emerging infectious diseases or cancers. Strategies to circumvent the pre-existing neutralizing antibodies which dampen the immunogenicity of Ad-based vaccines are also discussed.

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Crossref · 10.1080/21645515.2016.1165908

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  1. [106]Baden LR, Liu JY, Li HL, Johnson JA, Walsh SR, Kleinjan JA, Engelson BA, Peter L, Abbink P, Milner DA Jr, et al. Induction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humans. J Infect Dis 2015; 211: 518- 28; PMID:25165165 http://dx.doi.org/ 10.1093/infdis/jiu485 25165165 PMC4318919 · DOI
  2. [108]Van Kampen KR, Shi ZK, Gao P, Zhang JF, Foster KW, Chen DT, Marks D, Elmets CA, Tang DC. Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans. Vaccine 2005; 23: 1029- 36; PMID:15620476; http://dx.doi.org/ 10.1016/j.vaccine.2004.07.043 15620476 · DOI

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Authors
Zhang, C., & Zhou, D.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
Zhou, Dongming
Venue
Human Vaccines & Immunotherapeutics
Published
2016-04-22
Volume
12
Issue
8
Pages
2064-2074
ISSN
  • 2164-5515 (ISSN-L)
  • 2164-554X
OpenAlex
W2338153609
Cited by
110
References
142
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 18 · 2021: 27 · 2020: 21 · 2019: 13 · 2018: 6 · 2017: 6 · 2016: 1
FWCI
1.16
Type
journal article
Language
en
Open access
Locations
  • Human Vaccines & Immunotherapeutics (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
adenoviral vector, adenovirus, gene therapy vectors, adenovirus vector vaccine, emerging infectious diseases, neutralizing antibodies, immunogenicity, T cell response, antibody response, apoptosis induction
MeSH terms
Adenoviridae, Drug Carriers, Genetic Vectors, Humans, Neoplasms, Disease Transmission, Infectious, Oncolytic Virotherapy

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