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Cited by 32Bacteriophages and microbial interactionsPhotodynamic Therapy Research StudiesVirus-based gene therapy research

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The applications of animal models in phage therapy: An update

Open access
Mehmood Khan, Fazal, Manohar, Prasanth, Singh Gondil, Vijay, Mehra, Nancy, Kayode Oyejobi, Greater, Odiwuor, Nelson, Ahmad, Tauseef, Huang, Guangtao·2023·Human Vaccines & Immunotherapeutics
DOI 10.1080/21645515.2023.2175519PMC PMC10072079
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Abstract

The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various in-vivo models. PT has been evaluated in several recent clinical trials. However, there are still several unanswered concerns due to a lack of appropriate regulation and pharmacokinetic data regarding the application of phages in human therapeutic procedures. In this review, we also presented the current state of PT and considered how animal models can be used to adapt these therapies for humans. The development of realistic solutions to circumvent these constraints is critical for advancing this technology.

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  • Mouse models remain the gold standard for preclinical evaluation of phage therapy in cancer.

    “Mouse models remain the gold standard for preclinical evaluation of phage therapy in cancer [114]”

    From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [114]

    The “In vivo animal trials of phage therapy” section (page not provided) says murine models are the most commonly employed animals in phage therapy research. It discusses their use for bacterial infections and host immune responses, but does not establish that they are the gold standard for preclinical evaluation of phage therapy in cancer. (LLM, conf=0.85)

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Metadata

Authors
Mehmood Khan, F., Manohar, P., Singh Gondil, V., Mehra, N., Kayode Oyejobi, G., Odiwuor, N., Ahmad, T., & Huang, G.
Affiliations
  • Shenzhen University
  • Vellore Institute of Technology University (IN)
  • Chinese Academy of Sciences
  • Post Graduate Institute of Medical Education and Research (IN)
  • Chinese Academy of Sciences (CN)
  • Southeast University (CN)
  • Shenzhen University (CN)
Corresponding author
  • Ahmad, Tauseef
  • Huang, Guangtao
ORCID
Venue
Human Vaccines & Immunotherapeutics
Publisher
Informa UK Limited
Published
2023-01-02
Volume
19
Issue
1
Pages
2175519-2175519
ISSN
  • 2164-5515 (ISSN-L)
  • 2164-554X
DOI
10.1080/21645515.2023.2175519
PMC
PMC10072079
OpenAlex
W4327892892
Cited by
32
References
1
Citations by year
2026: 9 · 2025: 8 · 2024: 9 · 2023: 6
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Human Vaccines & Immunotherapeutics (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (32250410292., 81960353 and 82172238)
  • Science and Technology Support Project of Guizhou Province (2020-1Y332)
  • Sanming Project of Medicine in Shenzhen (SZSM202111020)
  • Science and Technology Cooperation Project of Zunyi Science and Technology Bureau (HZ-2019-50)
  • Health Commission Science and Technology Fund Project of Guizhou Province (gzwjkj2019-1-151)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords
phage therapy, animal models, antibiotic resistance, preclinical models, clinical trials, pharmacokinetics
MeSH terms
Phage Therapy, Animals, Anti-Bacterial Agents, Bacterial Infections, Bacteriophages, Humans, Models, Animal, Drug Resistance, Multiple, Bacterial

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