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The validation of the Italian Edinburgh Cognitive and Behavioural ALS Screen (ECAS)
Abstract
This study presents the Italian validation of the recently developed Edinburgh Cognitive and Behavioural ALS Screen (ECAS), a short screen for cognitive/behavioural alterations in patients with amyotrophic lateral sclerosis (ALS). We evaluated the psychometric properties of the ECAS Italian version in terms of reliability and convergent validity for both cognitive and behavioural features. Furthermore, we investigated the relationship with affective and clinical variables, in addition to ECAS usability and patients' insight into cognitive/behaviour changes. Finally, correlations between genetic and cognitive/behavioural data were analysed. We recruited 107 patients with ALS. Normative data were collected on 248 healthy subjects. Participants were administered the ECAS and two standard cognitive screening tools (FAB, MoCA), two psychological questionnaires (BDI, STAI/Y) and an ad hoc usability questionnaire. The FBI was also carried out with caregivers. Results showed that the ECAS Italian version discriminated well between patients and controls. The most prevalent deficit occurred in executive functions and fluency. Correlations were observed between the ECAS and standard cognitive screening tools and between the ECAS carer interview and the FBI, supporting its full convergent validity. In conclusion, the ECAS Italian version provides clinicians with a rapid, feasible and sensitive tool, useful to identify different profiles of cognitive-behavioural impairment in ALS.
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“the presence of cognitive impairments that significantly limited comprehension of the contents of the tests carried out and the interview, assessed using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) [32] in the case of patients with ALS or The Montreal Cognitive Assessment (MOCA) in case of the other diseases [33].”
From Life Experiences in Neuromuscular Tracheotomized Patients in Times of Covid-19 (2023) · cites this paper as [32]
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Metadata
- Authors
- Poletti, B., Solca, F., Carelli, L., Madotto, F., Lafronza, A., Faini, A., Monti, A., Zago, S., Calini, D., Tiloca, C., Doretti, A., Verde, F., Ratti, A., Ticozzi, N., Abrahams, S., & Silani, V.
- Affiliations
- IRCCS Istituto Auxologico Italiano (IT)
- University of Milano-Bicocca (IT)
- Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Milan, Italy,
- University of Milan (IT)
- Euan MacDonald Centre for Motor Neuron Disease Research (GB)
- Corresponding author
- Poletti, Barbara
- ORCID
- Venue
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Publisher
- Informa UK Limited
- Published
- 2016-05-24
- Volume
- 17
- Issue
- 7-8
- Pages
- 489-498
- ISSN
- 2167-8421 (ISSN-L)
- 2167-9223
- OpenAlex
- W2338131205
- Cited by
- 171
- References
- 38
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 21 · 2023: 27 · 2022: 28 · 2021: 21 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 1
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Funders
- Medical Research Council (MR/K026992/1)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- ECAS, amyotrophic lateral sclerosis, cognitive screening, behavioural impairment, Italian validation, psychometric properties, convergent validity, reliability statistics, executive dysfunction, caregiver interviews, affective symptoms
- MeSH terms
- C9orf72 Protein, Age Factors, Aged, Amyotrophic Lateral Sclerosis, Mental Disorders, Cognition Disorders, Female, Humans, Italy, Male, Middle Aged, Neuropsychological Tests, Proteins, Psychometrics, Statistics as Topic, Reproducibility of Results
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