The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way
Open accessAbstract
Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim of this study was to investigate whether exosomes from hypoxia-treated MSCs (ExoH) are superior to those from normoxia-treated MSCs (ExoN) for myocardial repair. Mouse bone marrow-derived MSCs were cultured under hypoxia or normoxia for 24 h, and exosomes from conditioned media were intramyocardially injected into infarcted heart of C57BL/6 mouse. ExoH resulted in significantly higher survival, smaller scar size and better cardiac functions recovery. ExoH conferred increased vascular density, lower cardiomyocytes (CMs) apoptosis, reduced fibrosis and increased recruitment of cardiac progenitor cells in the infarcted heart relative to ExoN. MicroRNA analysis revealed significantly higher levels of microRNA-210 (miR-210) in ExoH compared with ExoN. Transfection of a miR-210 mimic into endothelial cells (ECs) and CMs conferred similar biological effects as ExoH. Hypoxia treatment of MSCs increased the expression of neutral sphingomyelinase 2 (nSMase2) which is crucial for exosome secretion. Blocking the activity of nSMase2 resulted in reduced miR-210 secretion and abrogated the beneficial effects of ExoH. In conclusion, hypoxic culture augments miR-210 and nSMase2 activities in MSCs and their secreted exosomes, and this is responsible at least in part for the enhanced cardioprotective actions of exosomes derived from hypoxia-treated cells.
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Cites
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N. B., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,750
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
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Biogenesis and secretion of exosomes
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Current methods for the isolation of extracellular vesicles
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Cited by
Liu, W., Rong, Y., Wang, J., Zhou, Z., Ge, X., Ji, C., Jiang, D., Gong, F., Li, L., Chen, J., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1726-7 · Cited by 573
Self-citationHypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT
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Liu, W., Li, L., Rong, Y., Qian, D., Chen, J., Zhou, Z., Luo, Y., Jiang, D., Cheng, L., Zhao, S., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.12.020 · Cited by 466
Self-citationBrennan, M. Á., Layrolle, P., & Mooney, D. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909125 · Cited by 396
Huang, P., Wang, L., Li, Q., Tian, X., Xu, J., Xu, J., Xiong, Y., Chen, G., Qian, H., Jin, C., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz139 · Cited by 371
Metadata
- Authors
- Zhu, J., Lu, K., Zhang, N., Zhao, Y., Ma, Q., Shen, J., Lin, Y., Xiang, P., Tang, Y., Hu, X., Chen, J., Zhu, W., Webster, K. A., Wang, J., & Yu, H.
- Venue
- Artificial Cells, Nanomedicine, and Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2017-11-16
- Volume
- 46
- Issue
- 8
- Pages
- 1-12
- ISSN
- 2169-1401 (ISSN-L)
- 2169-141X
- OpenAlex
- W2769944691
- Cited by
- 264
- References
- 36
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhu, J., Lu, K., Zhang, N., Zhao, Y., Ma, Q., Shen, J., Lin, Y., Xiang, P., Tang, Y., Hu, X., Chen, J., Zhu, W., Webster, K. A., Wang, J., & Yu, H. (2017). Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way. Artificial Cells, Nanomedicine, and Biotechnology. https://doi.org/10.1080/21691401.2017.1388249
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