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Cited by 10Dementia and Cognitive Impairment ResearchPsychological Testing and AssessmentHistorical and Modern Theater Studies

Signs and symptoms method in neuropsychology: A preliminary investigation of a standardized clinical interview for assessment of cognitive decline in dementia

Abbate, Carlo, Trimarchi, Pietro Davide, Inglese, Silvia, Tomasini, Emanuele, Bagarolo, Renzo, Giunco, Fabrizio, Cesari, Matteo·2021·Applied Neuropsychology Adult
DOI 10.1080/23279095.2019.1630626
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Abstract

Psychologists usually perform a preliminary assessment of the person's cognitive status through a brief interview conducted before the formal testing. However, this exam has not yet been standardized with ad hoc recommendations in psychology literature. In this work, a standard observational NeuroPsychological Examination (NPE) designed for psychologists was proposed, and its clinical effectiveness evaluated. The NPE was administered to patients referred to a neuropsychological service in a memory clinic over a 2-year period. The NPEs of the patients with Alzheimer dementia (AD), vascular dementia (VaD), and healthy controls (HC) were retrospectively retrieved. Comparisons among the three groups were conducted. Abnormalities/signs identified during the NPE in the AD and VaD groups are more numerous compared to those reported in the HC group. About 80% of HCs show none or only one abnormal sign. Vice versa, 87.5% of both AD and VaD patients show three or more abnormalities. Accordingly, the NPE has 0.88 (95%CI = 0.81-0.95) sensitivity and 0.95 (95%CI = 0.88-1.02) specificity for detecting cognitive decline when a cut-point of three or more signs is applied. Some significant differences also emerge on the number of pathological signs between AD and VaD patients. NPE is a promising tool with demonstrated diagnostic utility in dementia patients.

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Crossref · 10.1080/23279095.2019.1630626

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  • AD is categorized into three stages: mild, moderate, and severe.

    “AD is categorized into three stages: mild, moderate, and severe [24,25,26,27,28].”

    From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [28]

  • The most common symptoms of AD are short-term memory loss, followed by progressive impairment in implicit and explicit memory, and neuropsychiatric symptoms with eventual loss of ability to perform basic daily duties.

    “The most common symptoms of AD are short-term memory loss, which is followed by a progressive impairment in both implicit and explicit memory. Those who have the condition also exhibit neuropsychiatric symptoms, and with time, they lose their ability to perform basic daily duties [24,25,26,27,28].”

    From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [28]

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Authors
Abbate, C., Trimarchi, P. D., Inglese, S., Tomasini, E., Bagarolo, R., Giunco, F., & Cesari, M.
Affiliations
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
  • Don Carlo Gnocchi Foundation (IT)
  • University of Milan (IT)
Corresponding author
Abbate, Carlo
ORCID
Venue
Applied Neuropsychology Adult
Publisher
Informa UK Limited
Published
2019-07-03
Volume
28
Issue
3
Pages
282-296
ISSN
  • 2327-9095 (ISSN-L)
  • 2327-9109
DOI
10.1080/23279095.2019.1630626
OpenAlex
W2955864087
Cited by
10
References
49
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Neuropsychology Adult (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
clinical interview, cognitive decline, dementia, Alzheimer's disease, vascular dementia, memory clinics, standardized assessment, sensitivity and specificity, neuropsychological assessment
MeSH terms
Alzheimer Disease, Humans, Neuropsychological Tests, Neuropsychology, Retrospective Studies, Dementia, Vascular, Cognitive Dysfunction

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