CoChat
Sign Up
Cited by 90Tryptophan and brain disordersBipolar Disorder and TreatmentTreatment of Major Depression

High-sensitivity C-reactive protein levels in patients with major depressive disorder and bipolar mania

Huang, Tiao-Lai, Lin, Fu-Chen·2007·Progress in Neuro-Psychopharmacology and Biological Psychiatry
DOI 10.1016/j.pnpbp.2006.09.010
Open this paper in CoChat — free account

Abstract

The serum high-sensitivity C-reactive protein (hsCRP) levels in patients with major depressive disorder and bipolar I disorder in acute phases were investigated. During a 1-year period, a total of 67 participants including 23 patients with major depressive disorder, 13 patients with bipolar I disorder (manic episode) and 31 healthy controls were recruited in this study. The diagnoses of mental disorders in participants were made by one psychiatrist according to the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Both patient groups with major depression and bipolar disorder had higher mean serum hsCRP levels than the healthy control group. Using analysis of covariance with age adjustment, patients with bipolar I disorders still had significantly higher hsCRP levels than healthy controls (P=0.043). However, patients with major depression did not have significantly higher hsCRP levels than healthy controls (P=0.172). These results suggest that patients with bipolar I disorder might have a more severe inflammation reaction than patients without major depression. However, larger samples and adequate statistical methods are needed to prove these results.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2006.09.010

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Huang and Lin (2007) reported higher hs-CRP levels in both MDD (n=23) and BD-I (n=13) groups compared to healthy controls (n=31).

    “Huang and Lin (2007) [59] reported higher hs-CRP levels in both MDD (n = 23) and BD-I (n = 13) groups compared to healthy controls (n = 31).”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [59]

  • No significant associations were found between CRP levels and MDD, even after adjusting for covariates.

    “No significant associations were found between CRP levels and MDD, even after adjusting for covariates;”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [59]

  • A significant association was found between CRP levels and BD-I, even after adjusting for covariates (p = 0.043).

    “while a significant association was found between CRP levels and BD-I, even after adjusting for covariates (p = 0.043).”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [59]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Huang, T.-L., & Lin, F.-C.
Affiliations
  • Chang Gung University (TW)
  • Chang Gung Memorial Hospital (TW)
Corresponding author
Huang, Tiao-Lai
ORCID
Huang, Tiao-Lai
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2007-03
Volume
31
Issue
2
Pages
370-372
ISSN
0278-5846 (ISSN-L)
DOI
10.1016/j.pnpbp.2006.09.010
OpenAlex
W1972224552
Cited by
90
References
28
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 9 · 2012: 7
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Council
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
high-sensitivity C-reactive protein, major depressive disorder, bipolar I disorder, manic episodes, inflammation, serum biomarkers, acute phase
MeSH terms
Adult, Analysis of Variance, Bipolar Disorder, C-Reactive Protein, Major Depressive Disorder, Female, Humans, Male, Middle Aged

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review