The DOI matches its Crossref record; 230 of the 232 references it cites were found in a registry or an index.
Circadian Variation in Stroke Onset: Identical Temporal Pattern in Ischemic and Hemorrhagic Events
Abstract
Stroke is the culmination of a heterogeneous group of cerebrovascular diseases that is manifested as ischemia or hemorrhage of one or more blood vessels of the brain. The occurrence of many acute cardiovascular events--such as myocardial infarction, sudden cardiac death, pulmonary embolism, critical limb ischemia, and aortic aneurysm rupture--exhibits prominent 24 h patterning, with a major morning peak and secondary early evening peak. The incidence of stroke exhibits the same 24 h pattern. Although ischemic and hemorrhagic strokes are different entities and are characterized by different pathophysiological mechanisms, they share an identical double-peak 24 h pattern. A constellation of endogenous circadian rhythms and exogenous cyclic factors are involved. The staging of the circadian rhythms in vascular tone, coagulative balance, and blood pressure plus temporal patterns in posture, physical activity, emotional stress, and medication effects play central and/or triggering roles. Features of the circadian rhythm of blood pressure, in terms of their chronic and acute effects on cerebral vessels, and of coagulation are especially important. Clinical medicine has been most concerned with the prevention of stroke in the morning, when population-based studies show it is of greatest risk during the 24 h; however, improved protection of at-risk patients against stroke in the early evening, the second most vulnerable time of cerebrovascular accidents, has received relatively little attention thus far.
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“It is known that cerebrovascular and cardiovascular events exhibit a bimodal pattern (116).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [116]
In the citing paper
“Strokes, for instance, follow a circadian rhythm with a major morning peak and a secondary early evening peak.”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [116]
In the citing paper
“Moreover, epidemiological data reveal a robust morning increase in adverse CV events, including stroke (7,8), myocardial infarction (9)(10)(11), serious ventricular arrhythmias (12), and sudden cardiac death (refs.11, 13, and Figure 1).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [8]
In the citing paper
“the vulnerable period for an adverse CV event in the general population is in the morning, coinciding with a morning surge in BP (183)”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [8]
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Role of the circadian system in cardiovascular disease
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Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health
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“This circadian rhythm is believed to reflect the circadian rhythms of vascular tone, coagulative balance, and blood pressure and may be affected by the temporal patterns of exogenous factors such as eating behavior and physical activity (116).”
BackgroundEffects of circadian disruption on the cardiometabolic system
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“In a recent review on ischemic and hemorrhagic stroke, Manfredini [20] also reports a double peak pattern with a secondary peak in the evening that interestingly is also seen in the occurrence of MIs in patients with sleep apnea [21].”
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Domínguez‐Rodríguez, A., Abreu-González, P., Sanchez-Sanchez, J. J., Kaski, J. C., & Reiter, R. J. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00773.x · Cited by 232
“[28], in a review on ischemic stroke, noted a secondary peak in the evening in the occurrence of myocardial infarction in patients with sleep apnea [29].”
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Impaired cerebral autoregulation in obstructive sleep apnea
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“Our findings provide evidence for one of the underlying reasons for higher risk of stroke during sleep and after rising (27).”
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“Interestingly, recent studies reveal the 24 h pattern and, in particular, the characteristic morning peak in the occurrence of both ischemic (Manfredini et al., 1997) and hemorrhagic (Casetta et al., 2002;Manfredini et al., 2005) stroke is the same in normotensive and hypertensive persons.”
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Beal, C. C. (2010) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0b013e3181ce5c70 · Cited by 127
“Multiple factors likely contribute to the timing of stroke onset including circadian fluctuations in vascular tone, blood pressure, and coagulation factors (Manfredini et al., 2005).”
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Chronobiological Influence Over Cardiovascular Function
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Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia
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“…variations, in fact, have been reported for acute myocardial infarction and sudden cardiac death (Arntz et al., 2000; Cohen et al., 1997; Manfredini et al., 2005a; Muller et al., 1985, 1987; Ornato et al., 1996; Spencer et al., 1998), congestive heart failure mortality (Boulay et al.,…”
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Roenneberg, T., Foster, F., & Klerman, E. B. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13621 · Cited by 81
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The Winter Peak in the Occurrence of Acute Aortic Dissection is Independent of Climate
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“Considerable evidence supports the seasonal patterning, with a significant winter peak, in the occurrence of a number of cardiovascular diseases, such as myocardial infarction, pulmonary embolism, and stroke (Ornato et al., 1996; Manfredini et al., 1995, 1997, 2005).”
BackgroundHaus, E. L. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.11.002 · Cited by 72
Atkinson, G., Jones, H., & Ainslie, P. N. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1243-y · Cited by 71
“The incidence of stroke exhibits a similar 24-h pattern as for the above acute cardiovascular events (Manfredini et al. 2005; Fig.”
Does sleep protect against ischemic stroke? less frequent ischemic strokes but more severe ones
Jiménez-Conde, J., Ois, Á., Rodríguez-Campello, A., Gomis, M., & Roquer, J. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0438-y · Cited by 69
“de Medicina Universitat Auto `noma de Barcelona Barcelona, Spain Tel.: +34-93/2483234 Fax: +34-93/2483376 E-Mail: JJimenez@imas.imim.es J Neurol (2007) 254:782‐788 DOI 10.1007/s00415-006-0438-y the hours after awakening [7, 17, 20, 21 ].”
ResultInfluentialJones, H., Taylor, C. E., Lewis, N. C. S., George, K., & Atkinson, G. (2009) · Chronobiology International · doi:10.1080/07420520902739717 · Cited by 67
“These data, taken together with the fact that sudden cardiovascular events peak in the morning (Hermida, 2007; Manfredini et al., 2005; Muller et al., 1989; Portaluppi et al., 1999; Smolensky et al., 2007), raise concern about the safety of early morning exercise for individuals at risk of these…”
BackgroundSeasonal Variation in Onset of Myocardial Infarction—A 7‐year single‐center study in Italy
Manfredini, R., Boari, B., Smolensky, M. H., Salmi, R., Gallerani, M., Guerzoni, F., Guerra, V., Malagoni, A. M., & Manfredini, F. (2005) · Chronobiology International · doi:10.1080/07420520500398106 · Cited by 64
“More recently, this winter preference has been confirmed for ischemic and hemorrhagic stroke (Gallerani et al., 1993, 1996; Manfredini et al., 2005), pulmonary embolism (Gallerani et al.”
BackgroundPlasminogen Activator Inhibitor-1 and the Circadian Clock in Metabolic Disorders
Oishi, K. (2009) · Clinical and Experimental Hypertension · doi:10.1080/10641960902822468 · Cited by 61
Effects of Time of Day on Post‐Exercise Blood Pressure: Circadian or Sleep‐Related Influences?
Jones, H., George, K., Edwards, B., & Atkinson, G. (2008) · Chronobiology International · doi:10.1080/07420520802548044 · Cited by 63
“Nevertheless, the variation is robust enough for the morning surge in BP to have been suggested as a reason for the morning-peak in sudden cardiovascular events (Manfredini et al., 2005; Muller et al., 1989; Portaluppi et al., 1999; Smolensky et al., 2007).”
BackgroundManfredini, R., Boari, B., Salmi, R., Fabbian, F., Pala, M., Tiseo, R., & Portaluppi, F. (2012) · Chronobiology International · doi:10.3109/07420528.2012.715843 · Cited by 58
“…share a cluster of triggering or promoting risk factors that can explain, at least partially, the nearly identical features—prominent peak in the morning around the time of commencing normal daily activities and second smaller peak late in the afternoon or early evening (Manfredini et al., 2005).”
BackgroundOishi, K., Uchida, D., Ohkura, N., Doi, R., Ishida, N., Kadota, K., & Horie, S. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.190140 · Cited by 59
Circadian clock and vascular disease
Takeda, N., & Maemura, K. (2010) · Hypertension Research · doi:10.1038/hr.2010.68 · Cited by 56
Daiber, A., Frenis, K., Kuntić, M., Li, H., Wolf, E., Kilgallen, A. B., Lecour, S., Laake, L. W. V., Schulz, R., Hahad, O., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0272 · Cited by 58
“A similar chronobiological pattern exists for the rupture and dissection of aortic aneurysms (139, 147, 242), as well as for ischemic and hemorrhagic stroke (140), which is unexpected as these events represent completely different clinical entities but obviously all of them share the same circadian mechanisms (143, 21…”
BackgroundOng, M. E., Ng, F. S., Overton, J., Yap, S., Andresen, D., Yong, D. K., Lim, S. H., & Anantharaman, V. (2009) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v38n3p184 · Cited by 54
Implications of Circadian Rhythm in Stroke Occurrence: Certainties and Possibilities
Fodor, D. M., Marta, M. M., & Perju‐Dumbravă, L. (2021) · Brain Sciences · doi:10.3390/brainsci11070865 · Cited by 55
Circadian rhythms in cardiovascular disease
Kelters, I. R., Koop, Y., Young, M. E., Daiber, A., & Laake, L. W. V. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf367 · Cited by 64
“102 As these events represent completely different entities, similarity in chronobiological patterns is unexpected, but obviously all of them share the same circadian mechanisms.”
Association of environmental factors with the onset of status epilepticus
Rüegg, S. J., Hunziker, P., Marsch, S. C. U., & Schindler, C. (2007) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2007.08.020 · Cited by 51
Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice
Schallner, N., Lieberum, J.-L., Gallo, D. J., LeBlanc, R. H., Fuller, P. M., Hanafy, K. A., & Otterbein, L. E. (2017) · Stroke · doi:10.1161/strokeaha.116.016165 · Cited by 52
“This daily rhythm of stroke occurrence cannot be attributed to external factors like physical activity, which suggests that the central circadian clock may be implicated in the pathophysiology of stroke.(3) The central circadian clock is located in the hypothalamic suprachiasmatic nuclei (SCN) and provides temporal or…”
Circadian Rhythm of Cardiovascular Disease: The Potential of Chronotherapy With Aspirin
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“Moreover, this early morning peak coincides with a high sensitivity of vascular receptors (14, 21).”
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PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice
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“Author, year Country Cases (n) Peak Notes [2] Manfredini et al.”
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Seasonality of Primarily Childhood and Young Adult Infectious Diseases in the United States
Shah, A. P., Smolensky, M. H., Burau, K. D., Cech, I. M., & Lai, D. (2006) · Chronobiology International · doi:10.1080/07420520600920718 · Cited by 44
“…pertaining to annual patterns in various acute and chronic medical conditions, such as depression (Murray et al., 2005), stroke (Manfredini et al., 2005a), myocardial infarction (Manfredini et al., 2005b), acute aortic dissection (Mehta et al., 2005), and pediatric trauma (Reinberg et al., 2005).”
BackgroundWithin-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke
Lorenzano, S., Ahmed, N., Tatlisumak, T., Gomis, M., Dávalos, A., Mikulík, R., Ševčík, P., Ollikainen, J., Wahlgren, N. G., & Toni, D. (2013) · Stroke · doi:10.1161/strokeaha.113.002133 · Cited by 43
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Stroke in the Time of Circadian Medicine
Mergenthaler, P., Balami, J. S., Neuhaus, A. A., Mottahedin, A., Albers, G. W., Rothwell, P. M., Saver, J. L., Young, M. E., & Buchan, A. M. (2024) · Circulation Research · doi:10.1161/circresaha.124.323508 · Cited by 43
Circadian rhythms in leukocyte trafficking
Druzd, D., de Juan, A., & Scheiermann, C. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-013-0414-4 · Cited by 43
Correlation between Sleep Duration and Risk of Stroke
Patyar, S., & Patyar, R. R. (2015) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.12.038 · Cited by 40
Circadian rhythm of stroke onset during the month of Ramadan
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“Also, in the present study, both ischemic and hemorrhagic strokes exhibit a diurnal pattern; this is in concordance with other studies (23, 24).”
ResultThe circadian system modulates the cortisol awakening response in humans
Bowles, N. P., Thosar, S. S., Butler, M. P., Clemons, N. A., Robinson, L. D., Ordaz-Johnson, O., Herzig, M. X., McHill, A. W., Rice, S. P. M., Emens, J. S., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.995452 · Cited by 46
“Although the CAR may be considered a physiological adaptation in healthy humans, the traditionally assessed CAR after nocturnal sleep coincides with the period of the day with the greatest risk for serious adverse cardiovascular events (Muller et al., 1985; Manfredini et al., 2005; Thosar et al., 2018a) and it is conc…”
BackgroundFoerch, C., Korf, H., Steinmetz, H., & Sitzer, M. (2008) · Circulation · doi:10.1161/circulationaha.108.771246 · Cited by 40
Seasonal Variation in the Occurrence of Venous Thromboembolism: Data From the MASTER Registry
Manfredini, R., Imberti, D., Gallerani, M., Verso, M., Pistelli, R., Ageno, W., & Agnelli, G. (2008) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029608319947 · Cited by 40
“Circannual rhythms in a variety of biological functions affecting blood coagulation, among others, have been discussed elsewhere with particular regard to seasonal variation in the incidence of acute myocardial infarction and stroke.(4,43) One of the advantages of a prospective registry with an adequate follow-up peri…”
BackgroundButt, M.-U.-R. A., Zakaria, M., & Hussain, H. M. (2009) · PubMed · Cited by 38
Kräuchi, K., Gompper, B., Hauenstein, D., Flammer, J., Pflueger, M. O., Studerus, E., Schötzau, A., & Orgül, S. (2012) · Chronobiology International · doi:10.3109/07420528.2012.719961 · Cited by 38
“The diurnal variation in BP may be linked to an increased incidence of many cardiovascular events, including stroke, sudden cardiac death and myocardial infarction (Manfredini et al., 2005; Stergiou et al., 2002).”
BackgroundResultInfluentialNew Insights into the Circadian Rhythm of Acute Myocardial Infarction in Subgroups
Garmendia-Leiza, J. R., de Llano, J. M. A., Messa, J. B. L., Alberola‐López, C., Fernández, J. A., & ARIAM Study Group (2007) · Chronobiology International · doi:10.1080/07420520601140027 · Cited by 38
“Previously published studies demonstrate a marked circadian variation in the onset time of myocardial infarction (Hansen et al., 1992; Manfredini et al., 2005a; Muller et al., 1985; Pepine, 1991; Sayer et al., 1997).”
BackgroundShift Work and Heart Rate Variability Coherence: Pilot Study Among Nurses
Burch, J. B., Alexander, M. S., Balte, P., Sofge, J., Winstead, J., Kothandaraman, V., & Ginsberg, J. P. (2018) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-018-9419-z · Cited by 47
“Adverse cardiovascular events, including myocardial infarction, sudden cardiac death, pulmonary embolism, and ischemic or hemorrhagic stroke, all exhibit a circadian pattern of risk, with a greater likelihood of occurrence in the early morning relative to night (Takeda and Maemura 2016; Manfredini et al. 2005; Portalu…”
BackgroundChronobiology and Chronotherapy in Inflammatory Joint Diseases
Ursini, F., Giorgi, A. D., D'Onghia, M., Giorgio, R. D., Fabbian, F., & Manfredini, R. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111832 · Cited by 36
Manfredini, R., Manfredini, F., Boari, B., Malagoni, A. M., Gamberini, S., Salmi, R., & Gallerani, M. (2009) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029609332111 · Cited by 35
Chronobiology in Aortic Diseases – “Is This Really a Random Phenomenon?”
Manfredini, R., Fabbian, F., Manfredini, F., Salmi, R., Gallerani, M., & Bossone, E. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.04.001 · Cited by 34
Using demand analysis and system status management for predicting ED attendances and rostering
Ong, M. E. H., Ho, K. K., Tan, T. P., Koh, S. K., Almuthar, Z., Overton, J., & Lim, S. H. (2008) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2008.01.032 · Cited by 30
Circadian Variations in Coagulation and Fibrinolytic Factors among Four Different Strains of Mice
Ohkura, N., Oishi, K., Sakata, T., Kadota, K., Kasamatsu, M., Fukushima, N., Kurata, A., Tamai, Y., Shirai, H., Atsumi, G., et al. (2007) · Chronobiology International · doi:10.1080/07420520701534673 · Cited by 28
“Twenty-four-hour variation in the incidence of myocardial infarction, sudden cardiac death, and cerebral infarction are thought to be responsible for transient risk states with thromboembolic and/or hemorrhagic tendencies (Manfredini et al., 1996, 2005).”
BackgroundBrito, L. C., Marin, T. C., Azevêdo, L. M., Rosa‐Silva, J. M., Shea, S. A., & Thosar, S. S. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210036 · Cited by 45
Lecour, S., du Pré, B. C., Bøtker, H. E., Brundel, B. J. J. M., Daiber, A., Davidson, S. M., Ferdinandy, P., Girão, H., Gollmann‐Tepeköylü, C., Gyöngyösi, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab293 · Cited by 29
Ambulance demand: random events or predicable patterns?
Cantwell, K., Dietze, P., Morgans, A., & Smith, K. L. (2012) · Emergency Medicine Journal · doi:10.1136/emermed-2012-201852 · Cited by 27
Gong, Y. Q., Zhang, G., Li, B., Cao, C., Cao, D., Li, X., Li, H., Ye, M., Shen, H., & Chen, G. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-1863 · Cited by 26
“At present, an increasing number of studies have shown that circadian rhythm disruption affects the occurrence, progression and clinical prognosis of ICH (59-61).”
BackgroundBikov, A., Kunos, L., Pállinger, É., Lázár, Z., Kis, A., Horváth, G., Losonczy, G., & Komlósi, Z. I. (2017) · Sleep And Breathing · doi:10.1007/s11325-017-1464-y · Cited by 26
“In addition, in the afternoon, the activity of tissue plasminogene activator [29] and the potential of platelets for aggregation [30] are on their rise.”
BackgroundCardiovascular disease, chronopharmacotherapy, and the molecular clock
Takeda, N., & Maemura, K. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.011 · Cited by 25
Racial Differences in Heart Rate Variability During Sleep in Women
Hall, M. H., Middleton, K. K., Thayer, J. F., Lewis, T. T., Kline, C. E., Matthews, K. A., Kravitz, H. M., Krafty, R. T., & Buysse, D. J. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182a7ec5c · Cited by 27
“A third advantage of sHRV is that these data may be especially important to understanding circadian variation in the timing of CVD events, which are more likely to occur during the early morning hours (19).”
BackgroundRecent Change in the Annual Pattern of Sexually Transmitted Diseases in the United States
Shah, A. P., Smolensky, M. H., Burau, K. D., Cech, I. M., & Lai, D. (2007) · Chronobiology International · doi:10.1080/07420520701648325 · Cited by 24
“…International have focused primarily on 24 h and/or seasonal variation in cardiovascular morbidity and mortality (Gallerani et al., 2007; Manfredini et al., 2005a, 2005b; Mehta et al., 2005) and annual patterns in common communicable infectious diseases that primarily affect young…”
BackgroundLemmer, B. (2012) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s21861 · Cited by 23
Seasonal Variation in Myocardial Infarction Is Limited to Patients with ST‐Elevations on Admission
Leibowitz, D. W., Planer, D., Weiss, T., & Rott, D. (2007) · Chronobiology International · doi:10.1080/07420520701800611 · Cited by 22
“(Manfredini et al., 2005a; van der Bom et al., 1997; Woodhouse et al., 1994).”
BackgroundResultSmolensky, M. H., Hermida, R. C., Portaluppi, F., & Haus, E. L. (2007) · Biological Rhythm Research · doi:10.1080/09291010600906166 · Cited by 22
Vilas, D., Gomis, M., Blanco, M., Cortés, J., Millán, M., de la Ossa, N. P., Dorado, L., Elena López-Cancio, M., Suñol, A., & Dávalos, A. (2012) · Chronobiology International · doi:10.3109/07420528.2012.728655 · Cited by 21
“Circadian rhythm has been described for the time of onset of acute vascular events, such as myocardial infarction, pulmonary embolism, and stroke, with a major morning peak and secondary early evening peak (Casetta et al., 2002; Manfredini et al., 2005).”
BackgroundLidington, D., Wan, H., Dinh, D. D., Ng, C., & Bolz, S.-S. (2021) · Stroke · doi:10.1161/strokeaha.121.036950 · Cited by 21
Changes in Chronotype after Stroke: A Pilot Study
Kantermann, T., Meisel, A., Fitzthum, K., Penzel, T., Fietze, I., & Ulm, L. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2014.00287 · Cited by 21
“The bimodality in the distribution of stroke onsets across the 24-h day indicates the potential for chronotherapies tailored for more individualized medicine, as also elaborated on previously by Manfredini and co-workers (3).”
BackgroundSeasonal variability of venous thromboembolism
Dentali, F., Manfredini, R., & Ageno, W. (2009) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32832d867a · Cited by 21
Have a safe night: intimate protection against cerebral hyperperfusion during REM sleep
Ainslie, P. N. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00091.2009 · Cited by 21
Hermida, R. C., Ayala, D. E., Khder, Y., & Calvo, C. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.01.012 · Cited by 20
Kuo, T. B. J., Hong, C.-H., Hsieh, I.-T., Lee, G., & Yang, C. C. H. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.03.022 · Cited by 20
Christersson, C., Lindahl, B., & Siegbahn, A. G. (2015) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2015.1086928 · Cited by 20
“Both MPs from activated platelets and endothelial cells were related to vWF as a marker for endothelial activation and these findings are in accordance with a circadian variation of the vascular system and platelet activity associated with the frequency of myocardial infarction and stroke [28,29].”
ResultCircadian Rhythm in Stroke – The Influence of Our Internal Cellular Clock on Cerebrovascular Events
LeBlanc, N. S. R. (2014) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.1000163 · Cited by 18
“While earlier studies focused on exogenous factors that influenced stroke frequency such as physical activity, food intake, stress or medication [9], researchers have become increasingly interested in the role that the internal clock might play in determining the onset and frequency of cerebrovascular events, as well…”
BackgroundCircadian variation of platelet function measured with the PFA-100®
Feuring, M., Wehling, M., Ruf, A., & Schultz, A. (2009) · Platelets · doi:10.3109/09537100903226034 · Cited by 18
“It is well known that potentially life-threatening events like myocardial infarction and stroke peak in the morning hours (6:00–9:00 h) with a second, smaller peak observed in the afternoon [1].”
BackgroundIschemic Stroke and Sleep: The Linking Genetic Factors
Коростовцева, Л. С. (2021) · Cardiology and Therapy · doi:10.1007/s40119-021-00231-9 · Cited by 17
Twenty‐Four‐Hour and Annual Variation in Onset of Epistaxis in Osler Disease
Sadick, H., Fleischer, I., GOESSLER, U. R., Hörmann, K., & Sadick, M. (2007) · Chronobiology International · doi:10.1080/07420520701284485 · Cited by 17
“…events, for example, myocardial infarction, stroke, and acute aortic dissection, and cerebrovascular events like subarachnoid haemorrhage (Cohen et al., 1997; Fogelholm et al., 1995; Gallerani et al., 1996; Manfredini et al., 2005a, 2005b; Mehta et al., 2005a, 2005b; Sloan et al., 1992).”
BackgroundWeekly Pattern of Stroke Onset in an Asian Country: A Nationwide Population‐Based Study
Lin, H., Lin, S.-Y., Lee, H., Hu, C., & Choy, C. (2008) · Chronobiology International · doi:10.1080/07420520802397194 · Cited by 16
“, 24 h and seasonal) patterns in stroke and other thrombosis-related medical events (Anderson et al., 2004; Feigin, & Nikitin, 1998; Gallerani et al., 2007; Haus, 2007; Khan et al., 2005; Manfredini et al., 2005; Sheth et al, 1999).”
BackgroundSex and Circadian Periodicity of Cardiovascular Diseases
Manfredini, R., Salmi, R., Cappadona, R., Signani, F., Basili, S., & Katsiki, N. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2017.05.008 · Cited by 16
Chronobiology of transient global amnesia
Hoyer, C., Higashida, K., Fabbian, F., Giorgi, A. D., Sandikci, V., Ebert, A., Platten, M., Okazaki, S., Manfredini, R., & Szabo, K. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10639-x · Cited by 15
Delisle, B. P., George, A. L., Nerbonne, J. M., Bass, J. T., Ripplinger, C. M., Jain, M. K., Hermanstyne, T. O., Young, M. E., Kannankeril, P. J., Duffy, J. F., et al. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.010190 · Cited by 16
Temporal Variations of Coagulation Factor VII Activity in Mice Are Influenced by Lighting Regime
Colognesi, I., Pasquali, V., Foà, A., Renzi, P., Bernardi, F., Bertolucci, C., & Pinotti, M. (2007) · Chronobiology International · doi:10.1080/07420520701282307 · Cited by 15
“…hemostatic balance and help explain 24 h variation in the frequency of human cardiovascular events (Angleton et al., 1989; Iversen et al., 2002; Kanikowska et al., 2005; Kapiotis et al., 1997; Manfredini et al., 2005a, 2005b; Muller et al., 1985; Pinotti et al., 2005; Touitou et al., 1986).”
BackgroundInfluences of the circadian clock on neuronal susceptibility to excitotoxicity
Karmarkar, S. W., & Tischkau, S. A. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00313 · Cited by 15
McHill, A. W., Melanson, E. L., Wright, K. P., & Depner, C. M. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16468 · Cited by 15
“…events including myocardial infarction, stroke, and sudden cardiac death occur more frequently in the early morning hours, with the circadian system regulating these temporal patterns (Andreotti et al., 1988; Cohen et al., 1997; Manfredini et al., 2005; Muller et al., 1985; Tofler et al., 1987).”
High Proportion of Lacunar Strokes at Night: The Bergen Stroke Study
Næss, H., Idicula, T. T., Brøgger, J. C., Waje‐Andreassen, U., & Thomassen, L. (2010) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2010.02.014 · Cited by 14
“Stroke onset also has been linked to circadian variations in blood coagulation and fibrinolysis.(17) Furthermore, a changing distribution of risk factors, such as the decline of smoking in Norway in recent years and improved diet, could possibly affect the timing of stroke onset and merits further study.”
BackgroundAndo, H., Otoda, T., OOKAMI, H., Nagai, Y., Inano, A., Takamura, T., Ushijima, K., Hosohata, K., Matsushita, E., Saito, T., et al. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12055 · Cited by 14
Normal hypercapnic cerebrovascular conductance in obstructive sleep apnea
Ryan, C. M., Battisti‐Charbonney, A., Sobczyk, O., Duffin, J., & Fisher, J. A. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.09.003 · Cited by 14
The Monday peak in the onset of ischemic stroke is independent of major risk factors
Manfredini, R., Manfredini, F., Boari, B., Salmi, R., & Gallerani, M. (2009) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2008.10.024 · Cited by 14
Circadian variation of stroke: a hospital based study
Fodor, D. M., Babiciu, I., & Perju‐Dumbravă, L. (2014) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-328 · Cited by 14
Metadata
- Authors
- Manfredini, R., Boari, B., Smolensky, M. H., Salmi, R., la Cecilia, O., Maria Malagoni, A., Haus, E., & Manfredini, F.
- Affiliations
- University of Ferrara (IT)
- The University of Texas Health Science Center at Houston (US)
- Vascular Diseases Center, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
- Regions Hospital (US)
- Corresponding author
- Manfredini, Roberto
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 22
- Issue
- 3
- Pages
- 417-453
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2104603409
- Cited by
- 197
- References
- 232
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 12 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 3 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 9
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- circadian rhythm, stroke onset, ischemic stroke, hemorrhagic stroke, morning peak, circadian variation, blood pressure, coagulation, vascular tone, stroke prevention
- MeSH terms
- Blood Coagulation, Blood Pressure, Cerebral Hemorrhage, Brain Ischemia, Circadian Rhythm, Pharmaceutical Preparations, Fibrinolysis, Humans, Motor Activity, Sleep, Stress, Psychological, Time Factors, Stroke
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