Effects of circadian disruption on the cardiometabolic system
Open accessAbstract
The presence of day-night variations in cardiovascular and metabolic functioning is well known. However, only recently it has been shown that cardiovascular and metabolic processes are not only affected by the behavioral sleep/wake cycle but are partly under direct control of the master circadian pacemaker located in the suprachiasmatic nucleus (SCN). Heart rate, cardiac autonomic activity, glucose metabolism and leptin-involved in appetite control-all show circadian variation (i.e., under constant behavioral and environmental conditions). This knowledge of behavioral vs. circadian modulation of cardiometabolic function is of clinical relevance given the morning peak in adverse cardiovascular incidents observed in epidemiological studies and given the increased risk for the development of diabetes, obesity, and cardiovascular disease in shift workers. We will review the evidence for circadian control of cardiometabolic functioning, as well its sensitivity to light and melatonin, and discuss potential implication for therapy.
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Circadian rhythm disturbances may be a major contributor to the contemporary global epidemics of T2DM, CVD and obesity.
“In the light of this, it has been suggested that the resulting circadian rhythm disturbances may be a major contributor to the contemporary global epidemics of T2DM, CVD and obesity 3, 5, 6, 7, 11, 15, 16, 17, 18, 19.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [6]
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- Authors
- Rüger, M., & Scheer, F. A. J. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Rüger, Melanie
- Venue
- Reviews in Endocrine and Metabolic Disorders
- Published
- 2009-09-26
- Volume
- 10
- Issue
- 4
- Pages
- 245-260
- ISSN
- 1389-9155 (ISSN-L)
- 1573-2606
- PMC
- PMC3026852
- OpenAlex
- W2055699557
- Cited by
- 232
- References
- 162
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 8 · 2023: 10 · 2022: 19 · 2021: 14 · 2020: 18 · 2019: 18 · 2018: 11 · 2017: 13 · 2016: 18 · 2015: 11 · 2014: 14 · 2013: 19 · 2012: 23
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Reviews in Endocrine and Metabolic Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH045130, 5R01MH45130-19)
- National Institute of Neurological Disorders and Stroke (5R01NS54277-3, R01NS054277)
- National Center for Complementary and Integrative Health (R21AT002713)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- circadian rhythm disruption, cardiometabolic function, suprachiasmatic nucleus, circadian rhythm, heart rate, cardiac autonomic activity, glucose metabolism, leptin, appetite regulation, shift work, cardiovascular disease, diabetes mellitus, obesity, light exposure, melatonin
- MeSH terms
- Animals, Cardiovascular System, Circadian Rhythm, Humans, Light, Melatonin, Suprachiasmatic Nucleus
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