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Cited by 197Acute Ischemic Stroke ManagementCircadian rhythm and melatoninBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 230 of the 232 references it cites were found in a registry or an index.

Circadian Variation in Stroke Onset: Identical Temporal Pattern in Ischemic and Hemorrhagic Events

Manfredini, Roberto, Boari, Benedetta, Smolensky, Michael H., Salmi, Raffaella, la Cecilia, Olga, Maria Malagoni, Anna, Haus, Erhard, Manfredini, Fabio·2005·Chronobiology International
DOI 10.1081/cbi-200062927
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Abstract

Stroke is the culmination of a heterogeneous group of cerebrovascular diseases that is manifested as ischemia or hemorrhage of one or more blood vessels of the brain. The occurrence of many acute cardiovascular events--such as myocardial infarction, sudden cardiac death, pulmonary embolism, critical limb ischemia, and aortic aneurysm rupture--exhibits prominent 24 h patterning, with a major morning peak and secondary early evening peak. The incidence of stroke exhibits the same 24 h pattern. Although ischemic and hemorrhagic strokes are different entities and are characterized by different pathophysiological mechanisms, they share an identical double-peak 24 h pattern. A constellation of endogenous circadian rhythms and exogenous cyclic factors are involved. The staging of the circadian rhythms in vascular tone, coagulative balance, and blood pressure plus temporal patterns in posture, physical activity, emotional stress, and medication effects play central and/or triggering roles. Features of the circadian rhythm of blood pressure, in terms of their chronic and acute effects on cerebral vessels, and of coagulation are especially important. Clinical medicine has been most concerned with the prevention of stroke in the morning, when population-based studies show it is of greatest risk during the 24 h; however, improved protection of at-risk patients against stroke in the early evening, the second most vulnerable time of cerebrovascular accidents, has received relatively little attention thus far.

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Crossref · 10.1081/cbi-200062927

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2 of the 232 references couldn’t be matched to a known paper.

Research works printed but not linked: 13

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Metadata

Authors
Manfredini, R., Boari, B., Smolensky, M. H., Salmi, R., la Cecilia, O., Maria Malagoni, A., Haus, E., & Manfredini, F.
Affiliations
  • University of Ferrara (IT)
  • The University of Texas Health Science Center at Houston (US)
  • Vascular Diseases Center, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
  • Regions Hospital (US)
Corresponding author
Manfredini, Roberto
ORCID
Venue
Chronobiology International
Publisher
Informa UK Limited
Published
2005-01
Volume
22
Issue
3
Pages
417-453
ISSN
  • 0742-0528 (ISSN-L)
  • 1525-6073
DOI
10.1081/cbi-200062927
OpenAlex
W2104603409
Cited by
197
References
232
Citations by year
2026: 7 · 2025: 5 · 2024: 12 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 3 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 9
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Locations
  • Chronobiology International (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
circadian rhythm, stroke onset, ischemic stroke, hemorrhagic stroke, morning peak, circadian variation, blood pressure, coagulation, vascular tone, stroke prevention
MeSH terms
Blood Coagulation, Blood Pressure, Cerebral Hemorrhage, Brain Ischemia, Circadian Rhythm, Pharmaceutical Preparations, Fibrinolysis, Humans, Motor Activity, Sleep, Stress, Psychological, Time Factors, Stroke

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