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Acetaminophen Hepatotoxicity: The First 35 Years
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“The reason for this widespread toxicity is that, unlike drugs associated with idiosyncrasy, APAP is a dose‐related hepatotoxin, with all mammalian species susceptible to liver injury in doses only 2 to 3 times therapeutic dosing.161”
From AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury (2023) · cites this paper as [161]
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Cites
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
Self-citationAcetaminophen Poisoning and Toxicity
Rumack, B. H., & Matthew, H. (1975) · Pediatrics · doi:10.1542/peds.55.6.871 · Cited by 640
Self-citationAcetaminophen Hepatotoxicity in Alcoholics: A Therapeutic Misadventure
SEEFF, L. B., CUCCHERINI, B. A., ZIMMERMAN, H. J., ADLER, E., & BENJAMIN, S. B. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-3-399 · Cited by 424
Acetaminophen Toxicity in an Urban County Hospital
Schiødt, F. V., Rochling, F. A., Casey, D. L., & Lee, W. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371602 · Cited by 422
Acetaminophen Overdose: 662 Cases With Evaluation of Oral Acetylcysteine Treatment
Rumack, B. H. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.1981.00340030112020 · Cited by 350
Self-citationSong, B. J., Veech, R. L., Park, S. S., Gelboin, H. V., & Gonzalez, F. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94103-7 · Cited by 277
Acetaminophen overdose: Incidence, diagnosis and management in 416 patients
Rumack, B. H., & Peterson, R. G. (1978) · Pediatrics · doi:10.1542/peds.62.5s.898 · Cited by 199
Self-citationMiners, J. O., Attwood, J., & Birkett, D. J. (1984) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1984.64 · Cited by 90
CYSTEAMINE FOR PARACETAMOL OVERDOSAGE
Prescott, L. F., Matthew, H., & Todd, J. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91316-6 · Cited by 35
Research works printed but not linked: 90
- 10.3109/15563659709043363 · DOI
- 10.1016/S0140-6736(71)91125-1 · DOI
- 10.1007/BF00607678 · DOI
- Mitchell J.R., 1973, J. Pharmacol. Exp. Ther., 187, 211
- 10.1016/S0140-6736(76)90030-1 · DOI
- 10.1016/S0140-6736(74)90510-8 · DOI
- 10.1056/NEJM197612022952306 · DOI
- 10.1016/S0140-6736(76)90105-7 · DOI
- 10.1177/000456327901600118 · DOI
- Blair D., 1977, Clin. Chem., 23, 743, 10.1093/clinchem/23.4.743 · DOI
- 10.1016/0140-6736(90)91388-Q · DOI · Paper page
- 10.1136/bmj.303.6809.1026 · DOI
- Mitchell J.R., 1973, J. Pharmacol. Exp. Ther., 187, 185
- Jollow D.J., 1973, J. Pharmacol. Exp. Ther., 187, 195
- Potter W.Z., 1973, J. Pharmacol. Exp. Ther., 187, 203
- 10.1159/000136531 · DOI
- 10.1016/S0196-0644(00)70055-2 · DOI
- 10.1055/s-2008-1040482 · DOI
- 10.3109/15563659309000383 · DOI
- 10.3109/15563659309000384 · DOI
- 10.1136/bmj.2.5512.506 · DOI
- 10.1136/bmj.2.5512.497 · DOI · Paper page
- 10.1016/0006-2952(93)90295-8 · DOI · Paper page
- 10.1046/j.1365-2125.2000.00167.x · DOI
- 10.1067/mcp.2000.104736 · DOI · Paper page
- 10.1021/bi00425a019 · DOI
- Umeno M., 1988, J. Biol. Chem., 263, 4956, 10.1016/S0021-9258(18)68880-5 · DOI
- 10.1016/0016-5085(94)90546-0 · DOI
- 10.1111/j.1530-0277.1996.tb01722.x · DOI
- 10.1177/019262339602400115 · DOI
- Waksman J.C., 2001, J. Toxicol. Clin. Toxicol., 39, 495
- Waksman J.C., 2001, J. Toxicol. Clin. Toxicol., 39, 486
- 10.1016/0006-2952(89)90217-7 · DOI
- Ronis M.J., 1993, J. Pharmacol. Exp. Ther., 264, 944
- 10.1111/j.1530-0277.1993.tb00861.x · DOI
- 10.1016/0006-2952(94)90524-X · DOI
- 10.1016/S0168-8278(98)80279-1 · DOI
- 10.1002/hep.1840100407 · DOI
- Terelius Y., 1992, Frontiers in Biotransformation, 182
- 10.1042/bj2150441 · DOI
- 10.1172/JCI111621 · DOI
- 10.1016/0006-2952(69)90089-6 · DOI
- 10.1016/0006-291X(88)90539-6 · DOI
- 10.1016/0304-4165(92)90156-O · DOI
- 10.1006/abbi.1993.1196 · DOI
- 10.1016/0006-291X(91)90481-L · DOI
- 10.1016/0006-2952(92)90418-I · DOI
- Chien J.Y., 1997, Drug Metab. Dispos., 25, 1165
- 10.1038/clpt.1993.85 · DOI
- 10.1073/pnas.87.8.3225 · DOI
- 10.1126/science.162.3856.917 · DOI
- 10.1126/science.159.3822.1469 · DOI
- 10.1111/j.1600-0773.1992.tb00485.x · DOI
- 10.2174/1389200013338676 · DOI
- 10.1016/0003-9861(89)90278-6 · DOI
- 10.1016/0041-008X(91)90125-X · DOI
- 10.1016/S0009-9236(98)90020-0 · DOI
- 10.1016/S0009-9236(97)90148-X · DOI
- 10.1074/jbc.271.20.12063 · DOI · Paper page
- 10.1006/taap.1998.8501 · DOI · Paper page
- Wright N., 1973, Scott. Med. J., 18, 56, 10.1177/003693307301800205 · DOI
- 10.1111/j.1365-2125.1979.tb00922.x · DOI
- Prescott L.F., 1981, Br. J. Clin. Pharmacol., 12, 149, 10.1111/j.1365-2125.1981.tb01193.x · DOI
- 10.1177/096032718800700106 · DOI
- 10.1177/096032719201100405 · DOI
- 10.1016/0016-5085(95)90758-0 · DOI
- 10.1007/s002280050132 · DOI
- 10.1053/gast.1996.v111.pm8698201 · DOI
- 10.1016/0741-8329(93)90064-U · DOI
- 10.1006/bbrc.1993.1117 · DOI
- Takahashi T., 1993, Hepatology, 17, 236
- 10.1097/00045391-200007020-00009 · DOI
- Himmelstein D.U., 1984, Am. J. Gastroenterol., 79, 718
- Zimmerman H.J., 1995, Hepatology, 22, 1898, 10.1002/hep.1840220648 · DOI
- 10.1056/NEJM199802193380810 · DOI
- Smilkstein M.J., 1998, J. Toxicol. Clin. Toxicol., 36, 476
- 10.1001/jama.1994.03520230055038 · DOI · Paper page
- 10.1054/clnu.2000.0371 · DOI
- Chien J.Y., 1998, Hepatology, 28, 380A
- 10.1067/mcp.2000.106574 · DOI
- Kuffner E.K., 1999, J. Toxicol. Clin. Toxicol., 37, 641
- 10.1001/archinte.161.18.2247 · DOI
- 10.1016/S0009-9236(96)90050-8 · DOI
- Rumack B.H., 1973, J. Pharmacol. Exp. Ther., 186, 441
- 10.1007/BF00562499 · DOI
- Gabrielle L., 1977, Gastroenterol. Clin. Biol., 1, 775
- 10.3109/00365518109090500 · DOI
- 10.1016/S0031-6989(82)80052-0 · DOI
- Newman T.J., 1979, Am. J. Gastroenterol., 72, 647
- 10.1016/0002-9343(83)90240-1 · DOI
Cited by
Stravitz, R. T., & Lee, W. M. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31894-x · Cited by 844
Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
(2016) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2015.00052 · Cited by 744
Drug-Induced Liver Injury Network (DILIN) Prospective Study: Rationale, Design and Conduct
Fontana, R. J., Watkins, P. B., Bonkovsky, H. L., Chalasani, N., Davern, T., Serrano, J., & Rochon, J. (2009) · Drug Safety · doi:10.2165/00002018-200932010-00005 · Cited by 486
Acetaminophen Hepatotoxicity and Acute Liver Failure
Chun, L. J., Tong, M. J., Busuttil, R. W., & Hiatt, J. R. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31818a3854 · Cited by 348
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Fontana, R. J., Liou, I., Reuben, A., Suzuki, A., Fiel, M. I., Lee, W., & Navarro, V. (2023) · Hepatology · doi:10.1002/hep.32689 · Cited by 340
Metadata
- Authors
- Rumack, B. H.
- Venue
- Journal of Toxicology: Clinical Toxicology
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 40
- Issue
- 1
- Pages
- 3-20
- ISSN
- 0731-3810
- Cited by
- 266
- References
- 9
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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